Patent US4564612A successfully refreshed from Google Patents.
US4564612A
Expired / Lapsed
US
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Condensed, seven-membered ring compounds and their use
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1984-04-11
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Granted: 1986-01-14
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Expires: 2004-04-11
Abstract
Abstract Novel condensed, seven-membered ring compounds of the formula: ##STR1## [wherein R 1 and R 2 each represent hydrogen, halogen, trifluoromethyl, lower alkyl or alkoxy, or both jointly form tri- or tetramethylene; R 3 is hydrogen, lower alkyl or aralkyl; R 4 is hydrogen or alkyl, aralkyl or cycloalkylalkyl which may be substituted; X is a group represented by the formula S(O) n (where n is an integer of 0 to 2); Y is a carboxyl group which may be esterified or amidated; m is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of hypertension.
Inventors
- 👤 Hirosada Sugihara
- 👤 Kohei Nishikawa
- 👤 Katsumi Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:32
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07D281/00; C07D281/02; C07D281/04; C07D281/08; C07D281/10; C07D417/00; C07D417/02; C07D417/04; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A61K; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
27 words
A compound of the formula ##STR61## wherein R 3 is hydrogen or C 1-4 alkyl and n is 6 or 7, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
27 words
A compound of the formula ##STR61## wherein R 3 is hydrogen or C 1-4 alkyl and n is 6 or 7, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein n is 6.
Claim 4
Dependent Claim
10 words
The compound according to claim 1 which is 3(R)-[7-amino-1-(S)-carboxyheptyl]-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid.
Claim 5
Dependent Claim
10 words
The compound according to claim 1 which is 3(R)-[7-amino-1-(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid.
Claim 6
Dependent Claim
11 words
The compound according to claim 1 which is 3(R)-[7-amino-1-(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid dihydrochloride.
Claim 7
Dependent Claim
10 words
A compound according to claim 1 which is 3(R)-[8-amino-1(S)-carboxyoctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid.
Claim 8
Dependent Claim
10 words
A compound according to claim 1 which is 3(R)-[8-amino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid.
Claim 9
Dependent Claim
55 words
A pharmaceutical composition suitable for treatment of hypertension which comprises, as an active ingredient, an effective anti-hypertensive amount of a compound of the formula ##STR62## wherein R 3' is hydrogen or C 1-4 alkyl and n is 6 or 7 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, excipient or diluent therefor.
Claim 10
Dependent Claim
55 words
A pharmaceutical composition suitable for treatment of hypertension which comprises, as an active ingredient, an effective anti-hypertensive amount of a compound of the formula ##STR62## wherein R 3' is hydrogen or C 1-4 alkyl and n is 6 or 7 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, excipient or diluent therefor.
Claim 11
Independent Claim
48 words
A method for treatment of hypertension in a mammal, which comprises administering to said mammal an effective antihypertensive amount of a compound of the formula ##STR63## wherein R 3' is hydrogen or C 1-4 alkyl a nd n is 6 or 7 or a pharmaceutically acceptable salt thereof.
Claim 12
Independent Claim
48 words
A method for treatment of hypertension in a mammal, which comprises administering to said mammal an effective antihypertensive amount of a compound of the formula ##STR63## wherein R 3' is hydrogen or C 1-4 alkyl a nd n is 6 or 7 or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
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EP0068173A1
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GB2103614A
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JPS5829779A
Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-13 | 1989-07-15 | 1990-01-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-13 | 1993-07-15 | 1994-01-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-13 | 1997-07-15 | 1998-01-14 | $7700.00 | Window Closed / Lapsed |