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US4563467A
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Derivatives of N-iminopyridinium betaines having anti-hypertensive and salidiuretic activity and their preparation
Assignee: Provesan SA
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Filing: 1984-02-06
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Granted: 1986-01-07
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Expires: 2004-02-06
Abstract
Abstract Derivatives of inner salts of aminopyridinium hydroxide and corresponding salts thereof comprising the general formuale I and II ##STR1## in which: R 1 as selected from the group consisting of a hydrogen and a radical 2-furyl-methyl-amino; R 2 , R 4 and R 6 are all selected from the group consisting of a hydrogen atom, a C 1 -C 1 linear or branched lower alkyl radical and a phenyl radical; R 3 is selected from the group consisting of a hydrogen or a carbamyl radical; R 5 represents a hydrogen; and X⊖ represents a monobasic anion of a pharmaceutically acceptable acid.
Inventors
- 👤 Jose E. Soler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:48
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; C07D213/80; C07D213/89; A; A61; A61P; A61P7/00; A61P7/10; C07D405/00; C07D405/02; C07D405/12
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
101 words
Derivatives of inner salts of aminopyridinium hydroxide and corresponding salts thereof comprising the general formulae I and II ##STR17## in which: R 1 as selected from the group consisting of a hydrogen and a radical 2-furyl-methyl-amino; R 2 , R 4 and R 6 are all selected from the group consisting of a hydrogen atom, a C 1 --C 1 linear or branched lower alkyl radical and a phenyl radical; R 3 is selected from the group consisting of a hydrogen or a carbamyl radical; R 5 represents a hydrogen; and X.sup.⊖ represents a monobasic anion of a pharmaceutically acceptable acid.
Claim 2
Dependent Claim
101 words
Derivatives of inner salts of aminopyridinium hydroxide and corresponding salts thereof comprising the general formulae I and II ##STR17## in which: R 1 as selected from the group consisting of a hydrogen and a radical 2-furyl-methyl-amino; R 2 , R 4 and R 6 are all selected from the group consisting of a hydrogen atom, a C 1 --C 1 linear or branched lower alkyl radical and a phenyl radical; R 3 is selected from the group consisting of a hydrogen or a carbamyl radical; R 5 represents a hydrogen; and X.sup.⊖ represents a monobasic anion of a pharmaceutically acceptable acid.
Claim 3
Dependent Claim
59 words
A derivative of the general formula I as claimed in claim 1 selected from amongst: the inner salt of 1-[(4-chloro-3-sulfamylbenzoyl)amino]-pyridinium hydroxide; the inner salt of 1-[(4-chloro-3sulfamylbenzoyl)-amino]-2,4,6-trimethylpyridinium hydroxide; the inner salt of 1-[(4-chloro-3-sulfamylbenzoyl)amino]-2,6-dimethyl-pyridinium hydroxide; the inner salt of 1-[(4-chloro-3-sulfamylbenzoyl)amino]-3-carbamylpyridinium hydroxide; the inner salt of 1-{[(4-chloro-2-(2-furylmethylamino)-5-sulphamylbenzoyl]-amino}-2,4,6-trimethylpyridinium hydroxide; and the inner salt of 1-[(4-chloro-3-sulfamyl-benzoyl)-amino]-2,4,6-trimethylpyridinium hydroxide; and the inner salt of 1-[(4-chloro-3-sulfamylbenzoyl)-amino]-2,4,6-triphenylpyridinium hydroxide.
Claim 4
Dependent Claim
22 words
A derivative of the general formula II as claimed in claim 1, selected from amongst: 1-[(4-chloro-3-sulfamylbenzoyl)-amino]-2,4,6-trimethylpyridinium chloride; 1-{[4-chloro-2-(2-furylmethylamino)-5-sulfamylbenzoyl]-amino}-2,4,6-trimethylpyridinium chloride; and 1-[(4-chloro-3-sulfamylbenzoyl)-amino]-2,4,6-triphenylpyridinium chloride.
Claim 5
Dependent Claim
25 words
An anti-hypertensive composition comprising an effective amount of said derivatives having the general formulae I or II as claimed in claims 1, 2 or 3.
Claim 6
Dependent Claim
35 words
A salidiuretic composition, comprising, in addition to a pharmaceutically acceptable carrier, an effective amount of a derivative selected from the group having the general formula I or II according to claims 1, 2, or 3.
References Cited (Backward Citations)
US4013669A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-06 | 1989-07-08 | 1990-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-06 | 1993-07-08 | 1994-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-06 | 1997-07-08 | 1998-01-07 | $7700.00 | Window Closed / Lapsed |