US4563431A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biologically active latex conjugate
Assignee: Hoechst AG
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Filing: 1984-03-26
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Granted: 1986-01-07
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Expires: 2004-03-26
Abstract
Abstract A biologically active latex conjugate prepared by the acidification of latex particles of a core/shell polymer having acetal groups in the shell, whereby said acetal groups are converted to aldehyde groups, and then bonding a biologically active substance having an amino group to said aldehyde groups by reductive amination.
Inventors
- 👤 Hans-Erwin Pauly
- 👤 Wolfgang Kapmeyer
- 👤 Ulrich Seitz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:59
CPC Classifications
C; C08; C08F; C08F291/00; Y; Y10; Y10S; Y10S436/00; Y10S436/805; Y10S525/00; Y10S525/902
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
153 words
A method for making a biologically active latex conjugate which method comprises: (1) acidifying latex particles comprising a core of a polymer of at least one ethylenically unsaturated monomer and a shell, graft polymerized to said core, of a copolymer comprising at least one ethylenically unsaturated monomer and an acetal monomer of the formula ##STR2## whereby acetal groups present in said shell are converted to aldehyde groups, and wherein, in said formula, n is 1 to 6, R 2 is H or CH 3 , and R 3 and R 4 are alkyl having 2 to 6 carbon atoms, aryl, or some other inert group imparting sufficient water insolubility to said monomer to permit graft polymerization thereof to said core polymer in an aqueous latex of core polymer particles, (2) bonding a biologically active substance having an amino group to the surface of said latex particles by reductive amination of said aldehyde groups.
Claim 2
Independent Claim
153 words
A method for making a biologically active latex conjugate which method comprises: (1) acidifying latex particles comprising a core of a polymer of at least one ethylenically unsaturated monomer and a shell, graft polymerized to said core, of a copolymer comprising at least one ethylenically unsaturated monomer and an acetal monomer of the formula ##STR2## whereby acetal groups present in said shell are converted to aldehyde groups, and wherein, in said formula, n is 1 to 6, R 2 is H or CH 3 , and R 3 and R 4 are alkyl having 2 to 6 carbon atoms, aryl, or some other inert group imparting sufficient water insolubility to said monomer to permit graft polymerization thereof to said core polymer in an aqueous latex of core polymer particles, (2) bonding a biologically active substance having an amino group to the surface of said latex particles by reductive amination of said aldehyde groups.
Claim 3
Dependent Claim
12 words
A biologically active latex conjugate made by the method of claim 1.
Claim 4
Dependent Claim
24 words
A latex conjugate as in claim 2 wherein R 3 and R 4 are alkyl having 2 to 6 carbon atoms or are aryl.
Claim 5
Dependent Claim
13 words
A latex conjugate as in claim 2 wherein said core polymer is polystyrene.
Claim 6
Dependent Claim
15 words
A latex conjugate as in claim 2 wherein said acetal monomer is methacrylamidoacetaldehyde di-n-pentyl acetal.
Claim 7
Dependent Claim
21 words
A latex conjugate as in claim 4 wherein said shell is a copolymer of methacrylamidoacetaldhyde di-n-pentyl acetal, methacrylic acid, and styrene.
Claim 8
Dependent Claim
17 words
A latex conjugate as in claim 2 wherein said biologically active substance is an immunologically active substance.
References Cited (Backward Citations)
US4210723A
Cited
US4448908A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-06 | 1989-07-08 | 1990-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-06 | 1993-07-08 | 1994-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-06 | 1997-07-08 | 1998-01-07 | $7700.00 | Window Closed / Lapsed |