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US4559322A
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Non-absorbable compounds of mucolytic activity, the process for their preparation, and therapeutic compositions which contain them as active principle
Assignee: Texcontor
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Filing: 1983-07-11
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Granted: 1985-12-17
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Expires: 2003-07-11
Abstract
Abstract Macromolecular compounds of mucolytic activity, non-absorbable by tissues, free from side-effects, compatible with antibiotics, and constituted by carbohydrates as their basic structure, to which enzymes and sulphydryl groups are bonded by suitable aliphatic chains.
Inventors
- 👤 Javier E. Maltz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:26
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; C12N11/10; A; A61; A61K; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K38/465; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/62; A61K47/64; A61P; A61P11/00; A61P11/10; A61P29/00; C12N11/08; C12N11/082; C12N11/087; C12Y; C12Y301/00; C12Y301/21; C12Y301/21001
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
76 words
A compound of mucolytic activity, not adsorbable by tissues, with a molecular weight between 10,000 and 300,000 of the formula: ##STR14## wherein: R 2 is --COOH or --CONH 2 n is 1 to 2000 m is 0 to 1000 R 3 is --CO--, --COO(CH 2 ) 3 --O-- --NHE represents the radical of an enzyme chosen from deoxyribonuclease and trypsin, each carbohydrate unit carrying at least one enzyme residue and at least one free sulphydryl group.
Claim 2
Dependent Claim
76 words
A compound of mucolytic activity, not adsorbable by tissues, with a molecular weight between 10,000 and 300,000 of the formula: ##STR14## wherein: R 2 is --COOH or --CONH 2 n is 1 to 2000 m is 0 to 1000 R 3 is --CO--, --COO(CH 2 ) 3 --O-- --NHE represents the radical of an enzyme chosen from deoxyribonuclease and trypsin, each carbohydrate unit carrying at least one enzyme residue and at least one free sulphydryl group.
Claim 3
Dependent Claim
30 words
A therapeutic composition having mucolytic activity for topical or aerosol application, comprising a mucolytically effective amount of a compound according to claim 1 and a therapeutically acceptable diluent or carrier.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-16 | 1989-06-17 | 1989-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-16 | 1993-06-17 | 1993-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-16 | 1997-06-17 | 1997-12-17 | $7700.00 | Window Closed / Lapsed |