N-(Aryloxyalkyl)-N'-(aminoalkyl)thioureas

Claim 1

A N-(Aryloxyalkyl)-N'-(aminoalkyl)thiourea selected from the group of compounds of the formula ##STR9## wherein Ar is 1 and 2-naphthyl, 2,3-dihydro-1H-inden-4(or 5)-yl, 3-pyridinyl, phenyl or phenyl substituted by 1-3 radicals which may be the same or different selected from the group consisting of loweralkyl, loweralkoxy, halogen, trifluoromethyl, amino, cyano, aminocarbonyl, nitro, loweralkylthio, loweralkylsulfinyl, loweralkylsulfonyl, loweralkanoyl, benzolyamino or loweralkanoylamino; R 1 and R 2 are selected from the group consisting of hydrogen, loweralkyl, cycloalkyl containing 3 to 9 carbon atoms, phenyl, phenyl substituted by halogen, loweralkyl or loweralkoxy or phenyl-loweralkyl wherein phenyl may be substituted by halogen, loweralkyl or loweralkoxy; R 3 and R 4 are selected from the group consisting of hydrogen, loweralkyl, phenyl and phenyl-loweralkyl and may be the same or different, or R 3 and R 4 taken together with the adjacent nitrogen form a heterocyclic residue selected from the group consisting of pyrrolidino, piperidino, 4-phenylpiperidino, 2,6-loweralkyl-piperidino, 4-hydroxy-4-phenylpiperidino, 4-cyano-4-phenylpiperidino, 4-phenyl-1,2,3,6-tetrahydropyridino, piperazino, 4-loweralkyl-piperazino, 4-phenyl-piperazino, 4-phenyl-loweralkyl-piperazino or morpholino radicals; with the proviso that Ar is not unsubstituted phenyl when R 3 and R 4 are each ethyl groups or are together a pyrrolidino group; alk 1 and alk 2 are selected from the group consisting of loweralkylene or loweralkylene-loweralkyl and may be the same or different, or a pharmaceutically acceptable addition salt or hydrate thereof.