Patent US4556641A successfully refreshed from Google Patents.
US4556641A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of judging a particle agglutination reaction and a reaction vessel for use in the method
Assignee: Olympus Corp
•
Filing: 1982-10-29
•
Granted: 1985-12-03
•
Expires: 2002-10-29
Abstract
Abstract A reaction vessel having a ring-shaped flat bottom portion and a conically inclined bottom portion is used to detect a particle agglutination reaction. Image of particle patterns formed on the flat bottom portion, middle and lowermost portion of the inclined bottom portion are separately detected by first, second and third light receiving elements to produce first, second and third signals. When the first signal is within a predetermined standard range, the particle agglutination reaction is judged by comparing a difference between the second and third signals with a predetermined upper and lower standard values. Contrary to this, when the first signal is beyond the predetermined range, the judgement for the agglutination reaction is not effected.
Inventors
- 👤 Tokio Kano
- 👤 Akira Tamagawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:21
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/508; B01L3/5085; G; G01; G01N; G01N21/00; G01N21/01; G01N21/03; G01N21/75; G01N21/77; G01N21/82; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/5302; G01N33/5304; Y; Y10; Y10S; Y10S436/00; Y10S436/805
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
209 words
A method of judging whether or not a particle agglutination reaction has occurred by detecting a particle pattern formed on a bottom surface of a reaction vessel containing a test liquid undergoing agglutination testing, comprising: photoelectrically detecting a particle pattern formed on a flat substantially horizontal portion of the bottom surface of said reaction vessel to produce a first signal representing at least one of an amount of particles and a concentration of particles contained in the test liquid, said flat substantially horizontal portion of the bottom surface being positioned above and surrounding a centrally located inclined portion of the bottom surface; photoelectrically detecting a particle pattern formed by particles decending upon said centrally located inclined portion of the bottom surface of said reaction vessel to produce a second signal representing the particle pattern of the test liquid; and when said first signal is within predetermined upper and lower values, judging whether or not a particle agglutination reaction has occurred on the basis of said second signal, and when said first signal is outside said predetermined upper and lower values, judging whether or not a particle agglutination reaction has occurred on the basis of a corrected second signal, with the correction thereto being a function of the first signal.
Claim 2
Independent Claim
209 words
A method of judging whether or not a particle agglutination reaction has occurred by detecting a particle pattern formed on a bottom surface of a reaction vessel containing a test liquid undergoing agglutination testing, comprising: photoelectrically detecting a particle pattern formed on a flat substantially horizontal portion of the bottom surface of said reaction vessel to produce a first signal representing at least one of an amount of particles and a concentration of particles contained in the test liquid, said flat substantially horizontal portion of the bottom surface being positioned above and surrounding a centrally located inclined portion of the bottom surface; photoelectrically detecting a particle pattern formed by particles decending upon said centrally located inclined portion of the bottom surface of said reaction vessel to produce a second signal representing the particle pattern of the test liquid; and when said first signal is within predetermined upper and lower values, judging whether or not a particle agglutination reaction has occurred on the basis of said second signal, and when said first signal is outside said predetermined upper and lower values, judging whether or not a particle agglutination reaction has occurred on the basis of a corrected second signal, with the correction thereto being a function of the first signal.
Claim 3
Dependent Claim
35 words
A method according to claim 1, wherein when said first signal is within predetermined upper and lower values, the occurrence of a particle agglutination reaction is judged by comparing the second signal with standard values.
Claim 4
Dependent Claim
78 words
A method according to claim 1, wherein when said first signal is outside said predetermined upper and lower values a coefficient for correcting a variation in at least one of the particle concentration and the particle amount is calculated from said first signal, and said second signal is multiplied by said coefficient to produce said corrected second signal, and wherein the occurrence of a particle aggulatination reaction is judged by comparing said corrected second signal with standard values.
Claim 5
Dependent Claim
45 words
A method according to claim 3, wherein said coefficient is derived by dividing said first signal by a standard value of the first signal which is obtained when at least one of the particle concentration and the particle amount are within a predetermined standard range.
Claim 6
Dependent Claim
35 words
A method according to claim 1, wherein said second signal is generated by deriving a difference between the particle pattern formed on a lower portion and a middle portion of said centrally located inclined portion.
Claim 7
Dependent Claim
39 words
A method according to claim 5, wherein an image of the particle pattern on said flat substantially horizontal portion is formed on a first light receiving element and said first signal is produced by said first light receiving element.
Claim 8
Dependent Claim
58 words
A method according to claim 6, wherein an image of the particle pattern formed on said lower portion and said middle portion of said inclined portion are projected on second and third light receiving elements, respectively, each producing a photoelectrically converted output, and wherein said second signal is produced by deriving a difference between the photoelectrically converted outputs.
Claim 9
Dependent Claim
30 words
A method according to claim 5, wherein a light flux transmitted through said flat substantially horizontal portion is received by a first light receiving element to produce said first signal.
Claim 10
Dependent Claim
55 words
A method according to claim 8, wherein light fluxes transmitted through said lower portion and said middle portion of said inclined portion are separately received by second and third light receiving elements, respectively, each producing a photoelectrically converted output and wherein said second signal is produced by deriving a difference between the photoelectrically converted outputs.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-02 | 1989-06-03 | 1989-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-02 | 1993-06-03 | 1993-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-02 | 1997-06-03 | 1997-12-03 | $7700.00 | Window Closed / Lapsed |