US4556560A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for the treatment and prophylaxis of diaper rash and diaper dermatitis
Assignee: Procter and Gamble Co
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Filing: 1983-01-24
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Granted: 1985-12-03
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Expires: 2003-01-24
Abstract
Abstract Methods for the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste are disclosed. The methods of the present invention employ the topical application of a minimum inhibitory concentration of a pharmaceutically-acceptable lipase-inhibiting agent to the area in need of such treatment, or the area where prevention is desired. The lipase-inhibiting agent is preferably a water-soluble metallic salt, such as ZnCl2, and is preferably applied in combination with a barrier-like vehicle. The effectiveness of these methods is surprising in light of the present confusion and controversy surrounding the actual causes of diaper rash, and the heretofore unrecognized role of lipase as a factor in the cause of diaper rash and diaper dermatitis.
Inventors
- 👤 Kent W. Buckingham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 07:38
CPC Classifications
A; A61; A61F; A61F13/00; A61F13/15; A61F13/84; A61F13/8405; A61L; A61L15/00; A61L15/16; A61L15/18; A61P; A61P17/00
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
66 words
A method of treating and preventing diaper rash, or diaper dermatitis, caused by prolonged contact of human skin with body waste, which method comprises topically applying to an area in need of such treatment or prevention a minimum inhibitory concentration of a pharmaceutically-acceptable lipase-inhibiting agent selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 2
Independent Claim
66 words
A method of treating and preventing diaper rash, or diaper dermatitis, caused by prolonged contact of human skin with body waste, which method comprises topically applying to an area in need of such treatment or prevention a minimum inhibitory concentration of a pharmaceutically-acceptable lipase-inhibiting agent selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 3
Dependent Claim
29 words
A method according to claim 1 wherein the lipase-inhibiting agent is selected from the group consisting of the water-soluble salts of cobalt, lanthanum, tin, zinc, iron, and mixtures thereof.
Claim 4
Dependent Claim
67 words
A method according to claim 2 wherein the lipase-inhibiting agent is selected from the group consisting of zinc chloride, zinc acetate, zinc nitrate trihydrate, zinc nitrate hexahydrate, zinc sulfate, zinc sulfate heptahydrate, zinc sulfate hexahydrate, iron(II)chloride, iron(II)chloride tetrahydrate, iron(III)chloride, iron(III)chloride monohydrate, iron(III)chloride hexahydrate, iron(II)lactate, iron(III)lactate, iron(III)malate, iron(II)nitrate, iron(III)nitrate hexahydrate, iron(III)nitrate.9H 2 O, iron(II)sulfate and its hydrates, iron(III)sulfate and its hydrates, tin chloride, cobalt chloride and lanthanum chloride.
Claim 5
Dependent Claim
30 words
A method according to claim 2 wherein the lipase-inhibiting agent is selected from the zinc salts of the monocarboxylic fatty acids having from about 6 to about 12 carbon atoms.
Claim 6
Dependent Claim
24 words
A method according to claim 4 wherein the zinc salt of the monocarboxylic fatty acid has from about 8 to about 10 carbon atoms.
Claim 7
Dependent Claim
28 words
A method according to claim 3 wherein the lipase-inhibiting agent is selected from the group consisting of zinc chloride, zinc sulfate, iron(II)chloride, iron(III)chloride, tin chloride, and mixtures thereof.
Claim 8
Dependent Claim
13 words
A method according to claim 6 wherein the lipase-inhibiting agent is zinc chloride.
Claim 9
Dependent Claim
21 words
A method according to claim 2 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater.
Claim 10
Dependent Claim
21 words
A method according to claim 3 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater.
Claim 11
Dependent Claim
21 words
A method according to claim 6 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater.
Claim 12
Dependent Claim
21 words
A method according to claim 7 wherein the lipase-inhibiting agent is applied at a concentration of about 10 mM or greater.
Claim 13
Dependent Claim
21 words
A method according to claim 2 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater.
Claim 14
Dependent Claim
21 words
A method according to claim 3 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater.
Claim 15
Dependent Claim
21 words
A method according to claim 6 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater.
Claim 16
Dependent Claim
21 words
A method according to claim 11 wherein the lipase-inhibiting agent is applied at a concentration of about 50 mM or greater.
Claim 17
Dependent Claim
21 words
A method according to claim 2 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater.
Claim 18
Dependent Claim
21 words
A method according to claim 3 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater.
Claim 19
Dependent Claim
21 words
A method according to claim 6 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater.
Claim 20
Dependent Claim
21 words
A method according to claim 11 wherein the lipase-inhibiting agent is applied at a concentration of about 100 mM or greater.
Claim 21
Dependent Claim
87 words
In a disposable diaper comprising: (1) an absorbent core, (2) a topsheet, said topsheet superposed or co-extensive with one face of said core, and (3) a liquid impervious backsheet, said backsheet superposed or co-extensive with the face of said core opposite the face covered by said topsheet; the improvement comprising incorporating therein a lipase-inhibiting agent at its minimum inhibitory concentration or greater, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 22
Dependent Claim
87 words
In a disposable diaper comprising: (1) an absorbent core, (2) a topsheet, said topsheet superposed or co-extensive with one face of said core, and (3) a liquid impervious backsheet, said backsheet superposed or co-extensive with the face of said core opposite the face covered by said topsheet; the improvement comprising incorporating therein a lipase-inhibiting agent at its minimum inhibitory concentration or greater, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 23
Dependent Claim
16 words
An article according to claim 20 wherein the lipase-inhibiting agent is incorporated into the absorbent core.
Claim 24
Dependent Claim
15 words
An article according to claim 20 wherein the lipase-inhibiting agent is incorporated into the topsheet.
Claim 25
Dependent Claim
75 words
In a disposable wipe especially adapted for removing fecal matter from skin comprising: an absorbent fibrous material; the improvement comprising releasably incorporating into said absorbent material an amount of lipase-inhibiting agent sufficient to deliver a minimum inhibitory concentration of said agent to human skin when used to remove fecal matter, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 26
Dependent Claim
75 words
In a disposable wipe especially adapted for removing fecal matter from skin comprising: an absorbent fibrous material; the improvement comprising releasably incorporating into said absorbent material an amount of lipase-inhibiting agent sufficient to deliver a minimum inhibitory concentration of said agent to human skin when used to remove fecal matter, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 27
Dependent Claim
96 words
In a disposable wipe especially adapted for removing fecal matter from skin comprising: (1) an absorbent fibrous material; and (2) a feces-impermeable backing, said backing superposed or at least partially co-extensive with one face of said absorbent material; the improvement comprising releasably incorporating into said absorbent material an amount of lipase-inhibiting agent sufficient to deliver a minimum inhibitory concentration of said agent to human skin when used to remove fecal matter, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 28
Dependent Claim
96 words
In a disposable wipe especially adapted for removing fecal matter from skin comprising: (1) an absorbent fibrous material; and (2) a feces-impermeable backing, said backing superposed or at least partially co-extensive with one face of said absorbent material; the improvement comprising releasably incorporating into said absorbent material an amount of lipase-inhibiting agent sufficient to deliver a minimum inhibitory concentration of said agent to human skin when used to remove fecal matter, said lipase-inhibiting agent being selected from the group consisting of water-soluble salts of cadmium, cobalt, lead, mercury, molybdenum, nickel, silver, lanthanum, tin, zinc and iron.
Claim 29
Dependent Claim
24 words
An article according to claim 24 wherein the absorbent material has additionally releasably incorporated therein a safe and effective amount of skin cleansing agent.
Claim 30
Dependent Claim
15 words
An article according to claim 25 wherein the cleansing agent is an oleaginous cleansing agent.
Claim 31
Dependent Claim
37 words
A method of treating and preventing diaper rash, or diaper dermatitis, caused by prolonged contact of human skin with body waste comprising contacting the area in need of such treatment with an article according to claim 23.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-02 | 1989-06-03 | 1989-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-02 | 1993-06-03 | 1993-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-02 | 1997-06-03 | 1997-12-03 | $7700.00 | Window Closed / Lapsed |