US4279930A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for treating inflammation
Assignee: Pharmacia and Upjohn Co
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Filing: 1979-09-14
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Granted: 1981-07-21
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Expires: 1999-09-14
Abstract
Abstract A process for treating inflammation locally or topically by administering a compound of the formula: ##STR1## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; NH 2 , RNH, R' 2 N where R is lower alkyl of from 1 to 3 carbon atoms or lower acyl of from 1 to 3 carbon atoms and R' is lower alkyl of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers.
Inventors
- 👤 Charles M. Hall
- 👤 Eldridge M. Glenn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 01:01
CPC Classifications
C; C07; C07C; C07C49/00; C07C49/76; C07C49/84; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/72; C07C45/74; C07C49/82; C07C49/835
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
78 words
A process for treating inflammation comprising the administration of an anti-inflammatory amount of a compound of the formula: ##STR3## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers.
Claim 2
Dependent Claim
78 words
A process for treating inflammation comprising the administration of an anti-inflammatory amount of a compound of the formula: ##STR3## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers.
Claim 3
Dependent Claim
9 words
The process of claim 1 wherein M' is hydrogen.
Claim 4
Dependent Claim
10 words
The process of claim 1 where the compound is 1-(3-fluorophenyl)-3-(4-hydroxyphenyl)-prop-1-en-3-one.
Claim 5
Dependent Claim
10 words
The process of claim 1 where the compound is 1-(4-hydroxyphenyl)-3-(4-hydroxyphenyl)-prop-1-en-2-one.
Claim 6
Dependent Claim
10 words
The process of claim 1 where the compound is 1-(2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-prop-2-en-1-one.
Claim 7
Dependent Claim
79 words
A pharmaceutical composition for treatment of inflammation comprising from about 0.1% to about 50% a compound of the formula: ##STR4## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers.
Claim 8
Dependent Claim
79 words
A pharmaceutical composition for treatment of inflammation comprising from about 0.1% to about 50% a compound of the formula: ##STR4## wherein M and M' are hydrogen, hydroxy, halogen, lower alkyl of from 1 to 3 carbon atoms, lower alkoxy of from 1 to 3 carbon atoms; X, Y and Z are hydrogen, hydroxy, halogen, lower alkoxy of from 1 to 3 carbon atoms or lower acyloxy of from 1 to 6 carbon atoms, in association with appropriate pharmaceutical carriers.
Claim 9
Dependent Claim
9 words
The composition of claim 6 wherein M' is hydrogen.
Claim 10
Dependent Claim
10 words
The composition of claim 6 wherein the compound is 1-(3-fluorophenyl)-3-(4-hydroxyphenyl)-prop-1-en-2-one.
Claim 11
Dependent Claim
10 words
The composition of claim 6 wherein the compound is 1-(4-hydroxyphenyl)-3-(4-hydroxyphenyl)-prop-1-en-3-one.
Claim 12
Dependent Claim
10 words
The composition of claim 6 wherein the compound is 1-(2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-prop-3-en-1-one.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-07-20 | 1985-01-19 | 1985-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-07-20 | 1989-01-19 | 1989-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-07-20 | 1993-01-19 | 1993-07-21 | $7700.00 | Window Closed / Lapsed |