Patent US4555398A successfully refreshed from Google Patents.
US4555398A
Expired / Lapsed
US
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Sustained-release vasodilator
Assignee: JNC Corp
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Filing: 1983-09-22
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Granted: 1985-11-26
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Expires: 2003-09-22
Abstract
Abstract A vasodilator product having a sustained releasing function is produced by mixing and kneading an atoxic agent having vasodilating activity with a setting or thermoplastic resin and then molding them to form the molded product. Further, the vasodilator can be molded integratedly together with a medical device to be implanted into a human body. These vasodilators can be used not only for an operation of cerebral aneurysm, but also for drainage and vasodilator after microvascular anastomosis and endarterectomy.
Inventors
- 👤 Yoshifumi Oda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:43
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61L; A61L29/00; A61L29/14; A61L29/16; A61P; A61P9/00; A61P9/08; A61L2300/00; A61L2300/40; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
127 words
A sustained release vasodilator product in molded form which comprises (1) a vasodilating effective amount of an atoxic agent having vasodilating activity selected from at least one member of the group consisting of papaverine hydrochloride, nicardipine hydrochloride, diltiazem, cinnarizine, cyclandelate and bencyclane fumarate and (2) a member selected from the group consisting of (a) at least one setting resin selected from the group of silicone resin, cyano-acrylate resin, epoxy resin and polyimide resin, and (b) at least one thermoplastic resin selected from the group of polystyrene resin, polyolefin resin, polyvinyl chloride resin, cellulose acetate resin, polyamide resin, polyurethane resin and acrylic resin, said molded product being prepared by mixing and kneading the said atoxic agent with the setting or thermoplastic resin and subsequently molding the resultant mixture.
Claim 2
Dependent Claim
127 words
A sustained release vasodilator product in molded form which comprises (1) a vasodilating effective amount of an atoxic agent having vasodilating activity selected from at least one member of the group consisting of papaverine hydrochloride, nicardipine hydrochloride, diltiazem, cinnarizine, cyclandelate and bencyclane fumarate and (2) a member selected from the group consisting of (a) at least one setting resin selected from the group of silicone resin, cyano-acrylate resin, epoxy resin and polyimide resin, and (b) at least one thermoplastic resin selected from the group of polystyrene resin, polyolefin resin, polyvinyl chloride resin, cellulose acetate resin, polyamide resin, polyurethane resin and acrylic resin, said molded product being prepared by mixing and kneading the said atoxic agent with the setting or thermoplastic resin and subsequently molding the resultant mixture.
Claim 3
Dependent Claim
32 words
A sustained release vasodilator product which comprises a molded product according to claim 1 which is further integratedly molded with a medical device which is to be implanted into a human body.
Claim 4
Dependent Claim
41 words
A product according to claim 1 wherein from 1 to 60% by weight of the said atoxic agent and a monomer of the said setting resin are mixed and kneaded for 20 minutes to 2 hours at 0° to 100° C.
Claim 5
Dependent Claim
42 words
A product according to claim 1 wherein from 1 to 60% by weight of the said atoxic agent and the thermoplastic in plasticized form are mixed and kneaded for a period of 10 minutes to 10 hours at 0° to 100° C.
Claim 6
Dependent Claim
19 words
A product according to claim 1 wherein the atoxic agent is papaverine hydrochloride and the resin is silicone resin.
Claim 7
Dependent Claim
19 words
A product according to claim 2 wherein the atoxic agent is papaverine hydrochloride and the resin is silicone resin.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-25 | 1989-05-27 | 1989-11-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-25 | 1993-05-27 | 1993-11-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-25 | 1997-05-27 | 1997-11-26 | $7700.00 | Window Closed / Lapsed |