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Patent US4552765A successfully refreshed from Google Patents.
US4552765A
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Aletheine derivatives
Assignee: Santen Pharmaceutical Co Ltd
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Filing: 1983-04-25
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Granted: 1985-11-12
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Expires: 2003-04-25
Abstract
Abstract Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.
Inventors
- 👤 Itaru Mita
- 👤 Jun-ichi Iwao
- 👤 Tadashi Iso
- 👤 Masayuki Oya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61K31/21; A61K31/265; A61K31/27; C; C07; C07C; C07C327/00; C07C327/20; C07C327/22; C07C327/36; C07C333/00; C07C333/14; C07C333/18; G; G01; G01R; G01R19/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
80 words
A compound of the formula [i] and salts thereof, ##STR16## wherein R 1 is ##STR17## R 2 is hydrogen or carboxy; R 3 is lower alkanoyl, (lower alkylamino)thiocarbonyl or ##STR18## R 4 is hydrogen, lower alkyl or lower alkoxy; and m and n, are the same or different, each is 0 or 1, said lower alkyl and lower alkoxy refer to groups having 1 to 6 carbon atoms, and lower alkanoyl refers to groups having 2 to 6 carbon atoms.
Claim 2
Dependent Claim
80 words
A compound of the formula [i] and salts thereof, ##STR16## wherein R 1 is ##STR17## R 2 is hydrogen or carboxy; R 3 is lower alkanoyl, (lower alkylamino)thiocarbonyl or ##STR18## R 4 is hydrogen, lower alkyl or lower alkoxy; and m and n, are the same or different, each is 0 or 1, said lower alkyl and lower alkoxy refer to groups having 1 to 6 carbon atoms, and lower alkanoyl refers to groups having 2 to 6 carbon atoms.
Claim 3
Dependent Claim
11 words
A compound as in claim 1 wherein R 2 is hydrogen.
Claim 4
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is hydrogen.
Claim 5
Dependent Claim
14 words
A compound as in claim 1 wherein R 3 is acetyl, propionyl or benzoyl.
Claim 6
Dependent Claim
5 words
3-(Benzoylamino)-N-(2-benzoylthioethyl)propionamide as in claim 1.
Claim 7
Dependent Claim
5 words
N-(2-Acetylthioethyl)-3-(benzyloxycarbonylamino)propionamide as in claim 1.
Claim 8
Dependent Claim
5 words
3-(Benzyloxycarbonylamino)-N-(2-propionylthioethyl)propionamide as in claim 1.
Claim 9
Dependent Claim
113 words
A pharmaceutical composition useful for the treatment of liver damage, comprising (i) a pharmaceutical carrier and (ii) a compound of the formula and pharmaceutically acceptable salts thereof in an amount sufficient for the treatment of liver damage, ##STR19## wherein R 5 is hydrogen, lower alkanoyl or ##STR20## R 6 is hydrogen or carboxy; R 7 is hydrogen, lower alkanoyl, (lower alkylamino)thiocarbonyl or ##STR21## R 8 is hydrogen, lower alkyl or lower alkoxy; and m and n are the same or different, each is 0 to 1, said lower alkyl and lower alkoxy refer to groups having 1 to 6 carbon atoms, and lower alkanoyl refers to groups having 2 to 6 carbon atoms.
Claim 10
Dependent Claim
113 words
A pharmaceutical composition useful for the treatment of liver damage, comprising (i) a pharmaceutical carrier and (ii) a compound of the formula and pharmaceutically acceptable salts thereof in an amount sufficient for the treatment of liver damage, ##STR19## wherein R 5 is hydrogen, lower alkanoyl or ##STR20## R 6 is hydrogen or carboxy; R 7 is hydrogen, lower alkanoyl, (lower alkylamino)thiocarbonyl or ##STR21## R 8 is hydrogen, lower alkyl or lower alkoxy; and m and n are the same or different, each is 0 to 1, said lower alkyl and lower alkoxy refer to groups having 1 to 6 carbon atoms, and lower alkanoyl refers to groups having 2 to 6 carbon atoms.
Claim 11
Dependent Claim
11 words
A composition as in claim 8 wherein the compound is 3-(benzyloxycarbonylamino)-N-(2-propionylthioethyl)propionamide.
Claim 12
Dependent Claim
11 words
A composition as in claim 8 wherein the compound is 3-benzoylamino-N-(2-benzoylthioethyl)propionamide.
Claim 13
Dependent Claim
11 words
A composition as in claim 8 wherein the compound is N-(2-acetylthioethyl)-3-(benzyloxycarbonylamino)propionamide.
Claim 14
Dependent Claim
11 words
A composition as in claim 8 wherein the compound is 3-amino-N-(2-mercaptoethyl)propionamide.
Claim 15
Dependent Claim
11 words
A composition as in claim 8 wherein the compound is 3-(benzyloxycarbonylamino)-N-(2-mercaptoethyl)propionamide.
Claim 16
Dependent Claim
11 words
A composition as in claim 8 wherein the compound is 3-acetylamino-N-(2-acetylthioethyl)propionamide.
Claim 17
Dependent Claim
16 words
A method for treatment of liver damage which comprises administering a composition as in claim 8.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-11 | 1989-05-13 | 1989-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-11 | 1993-05-13 | 1993-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-11 | 1997-05-13 | 1997-11-12 | $7700.00 | Window Closed / Lapsed |