US4551467A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vasodilating cyanoalkyl esters of 1,4-dihydropyridines
Assignee: Bayer AG
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Filing: 1979-10-11
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Granted: 1985-11-05
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Expires: 1999-10-11
Abstract
Abstract The invention relates to 1,4-dihydropyridines as well as methods for the preparation of said 1,4-dihydropyridines and compositions contained therein. The invention also includes the use of said compounds and compositions for influencing circulation.
Inventors
- 👤 Egbert Wehinger
- 👤 Friedrich Bossert
- 👤 Wulf Vater
- 👤 Kurt Stoepel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 08:14
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; A; A61; A61P; A61P1/00; A61P11/00; A61P13/00; A61P13/02; A61P15/00; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
141 words
A compound of the formula I ##STR57## or a salt thereof in which R denotes a phenyl radical which is optionally substituted by one or two substituents selected from trifluoromethyl, nitro, halogen and cyano, or denotes a pyridyl radical, R 1 and R 3 are identical or different and denote an alkyl group with 1 to 4 carbon atoms, R 2 denotes a hydrogen atom or an alkyl group with 1 to 4 carbon atoms, A denotes a straight-chain or branched alkylene group with up to 4 carbon atoms, Y denotes a nitrile group and X denotes the group --COOR 7 , in which R 7 denotes a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical with up to 6 carbon atoms which is optionally interrupted in the chain by an oxygen atom and which is optionally substituted by trifluoromethyl.
Claim 2
Dependent Claim
141 words
A compound of the formula I ##STR57## or a salt thereof in which R denotes a phenyl radical which is optionally substituted by one or two substituents selected from trifluoromethyl, nitro, halogen and cyano, or denotes a pyridyl radical, R 1 and R 3 are identical or different and denote an alkyl group with 1 to 4 carbon atoms, R 2 denotes a hydrogen atom or an alkyl group with 1 to 4 carbon atoms, A denotes a straight-chain or branched alkylene group with up to 4 carbon atoms, Y denotes a nitrile group and X denotes the group --COOR 7 , in which R 7 denotes a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical with up to 6 carbon atoms which is optionally interrupted in the chain by an oxygen atom and which is optionally substituted by trifluoromethyl.
Claim 3
Dependent Claim
28 words
Compounds according to claim 1, in which R 1 and R 3 are identical or different and each is an alkyl group with 1 or 2 carbon atoms.
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is ethyl-2-cyanoethyl-1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-pyridine-3,5-dicarboxylate.
Claim 5
Dependent Claim
9 words
A compound according to claim 1 which is methyl-2-cyanoethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate.
Claim 6
Dependent Claim
9 words
A compound according to claim 1 which is isopropyl-2-cyanoethyl-1,4-dihydro-2,5-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicaboxylate.
Claim 7
Dependent Claim
9 words
A compound according to claim 1 which is β-methoxy-ethyl-2-cyanoethyl-1,4-dihydro-2,5-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate.
Claim 8
Dependent Claim
30 words
A pharmaceutical composition containing as an active ingredient an effective vasodilating influencing amount of a compound according to claim 1 in admixture with a solid, liquid or liquefied gaseous diluent.
Claim 9
Dependent Claim
17 words
A pharmaceutical composition of claim 7 in the form of a sterile or physiologically isotonic aqueous solution.
Claim 10
Dependent Claim
20 words
A composition according to claim 7 or 8 containing from 0.5 to 90% by weight of the said active ingredient.
Claim 11
Dependent Claim
23 words
A medicament in dosage unit form comprising an effective vasodilating amount of a compound according to claim 1 and an inert pharmaceutical carrier.
Claim 12
Dependent Claim
17 words
A medicament of claim 10 in the form of a tablet, pill, dragee, capsule, ampoule, or suppository.
Claim 13
Dependent Claim
41 words
A method of effecting vasodilation in warm-blooded animals which comprises administering to the animals an effective vasodilation amount of an active compound according to claim 1 either alone or in admixture with a diluent or in the form of a medicament.
Claim 14
Dependent Claim
28 words
A method according to claim 12 in which the active compound is administered intravenously in an amount of 0.01 to 10 mg per kg body weight per day.
Claim 15
Dependent Claim
28 words
A method according to claim 13 in which the active compound is administered intravenously in an amount of 0.05 to 5 mg per kg body weight per day.
Claim 16
Dependent Claim
28 words
A method according to claim 12 in which the active compound is administered orally in an amount of 0.05 to 20 mg per kg body weight per day.
Claim 17
Dependent Claim
28 words
A method according to claim 15 in which the active compound is administered orally in an amount of 0.5 to 5 mg per kg body weight per day.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-04 | 1989-05-06 | 1989-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-04 | 1993-05-06 | 1993-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-04 | 1997-05-06 | 1997-11-05 | $7700.00 | Window Closed / Lapsed |