US3923818A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,4-Dihydropyridines
Assignee: Bayer AG
•
Filing: 1973-06-04
•
Granted: 1975-12-02
•
Expires: 1993-06-04
Abstract
Abstract Derivatives of 4-substituted phenyl 1,4-dihydropyridine 3,5dicarboxylic acids substituted by lower alkyl groups in the 2and 6-positions, are cardiovascular agents. The compounds, of which 2,6-dimethyl-4-(2-(diethylaminoethoxy)phenyl)-1,4dihydropyridine-3,5 -dicarboxylic acid 3,5-diethyl ester is a typical example, can be prepared through condensation of a Beta -dicarbonyl compound with an amine and an aldehyde, of an ylidene- Beta -ketocarboxylic acid ester, with a Beta ketocarbonyl compound and an amine, of an aldehyde, an enamine and a Beta -ketocarbonyl compound, or through elaboration of the substituent on the phenyl group.
Inventors
- 👤 Friedrich Bossert
- 👤 Horst Meyer
- 👤 Wulf Vater
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:28
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
5 words
A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
13 words
The compound according to claim 1 which is 1-n-butyl-2,6-dimethyl-4-(2-ethoxycarbonylmethoxy-5-nitrophenyl)-1,4 -dihydropyridine-3,5-dicarboxylic acid diethyl ester.
Claim 4
Dependent Claim
10 words
A compound according to claim 1 wherein A is oxygen.
Claim 5
Dependent Claim
10 words
A compound according to claim 1 wherein A is sulphur.
Claim 6
Dependent Claim
30 words
A compound according to claim 1 wherein R is hydrogen or lower alkyl; each of R1 and R4 is lower alkyl, and each of R2 and R3 is lower alkoxy.
Claim 7
Dependent Claim
21 words
A compound according to claim 1 wherein each of R5 and R6 is hydrogen, lower alkoxy, nitro, halogeno, cyano or amino.
Claim 8
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-methoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3,5 -dicarboxylic acid dimethyl ester.
Claim 9
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-isopropoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3,5 -dicarboxylic acid diethyl ester.
Claim 10
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-propoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3,5 -dicarboxylic acid dipropyl ester.
Claim 11
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-ethoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3,5 -dicarboxylic acid dimethyl ester.
Claim 12
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-ethoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3,5 -dicarboxylic acid diisopropyl ester.
Claim 13
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(3-ethoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3,5 -dicarboxylic acid diethyl ester.
Claim 14
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(4-(2-ethoxycarbonylprop-2-oxy)phenyl)-1,4-dihydropyridine -3,5-dicarboxylic acid diethyl ester.
Claim 15
Dependent Claim
13 words
The compound according to claim 1 which is 1,2,6-trimethyl-4-(3-methoxy-4-ethoxycarbonylmethoxyphenyl)-1,4 -dihydropyridine-3,5-dicarboxylic acid diethyl ester.
Claim 16
Dependent Claim
12 words
The compound according to claim 1 which is 1,2,6-trimethyl-4-(4-(2-ethoxycarbonylprop-2-oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester.
Claim 17
Dependent Claim
12 words
The compound according to claim 1 which is 1,2,6-trimethyl-4-(4-(2-ethoxycarbonylprop-2-oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester.
Claim 18
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(3-ethoxycarbonylmethoxy-4-methoxyphenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid dimethyl ester.
Claim 19
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(3-ethoxycarbonylmethoxy-4-methoxyphenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid diethyl ester.
Claim 20
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(3-methoxy-4-ethoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid dimethyl ester.
Claim 21
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(3-methoxy-4-ethoxycarbonylmethoxyphenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid diethyl ester.
Claim 22
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-ethoxycarbonylmethoxy-5-nitrophenyl)-1,4-dihydropyridine -3,5-dicarboxylic acid diethyl ester.
Claim 23
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-ethoxycarbonylmethoxy-5-nitrophenyl)-1,4-dihydropyridine -3,5-dicarboxylic acid dimethyl ester.
Claim 24
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-ethoxycarbonylemthoxy-5-nitrophenyl)-1,4-dihydropyridine -3,5-dicarboxylic acid diisopropyl ester.
Claim 25
Dependent Claim
13 words
The compound according to claim 1 which is 2,6-dimethyl-4-(2-ethoxycarbonylmethoxy-5-bromophenyl)-1,4-dihydropyridine -3,5-dicarboxylic acid diethyl ester.
Claim 26
Dependent Claim
13 words
The compound according to claim 1 which is 1,2,6-trimethyl-4-(2-ethoxycarbonylmethylmercapto-5-nitrophenyl)-1,4 -dihydropyridine-3,5-dicarboxylic acid dimethyl ester.
References Cited (Backward Citations)
US3773773A
Cited
US3775422A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-01 | 1979-06-02 | 1979-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-01 | 1983-06-02 | 1983-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-01 | 1987-06-02 | 1987-12-02 | $7700.00 | Window Closed / Lapsed |