Unsymmetrical 1,4-dihydro-4-aryl-nicotinate esters

Abstract

Abstract 1,4-DIHYDROPYRIDINES OF THE FORMULA: 1-R,2-R4,3-(R4-CO-),4-R3,5-(R2-OOC-),6-R1-),4-DIHYDRO- WHEREIN ARE USEFUL FOR THEIR CORONARY DILATING EFFECT, THEIR NITRITELIKE EFFECT ON THE HEART, THEIR ANTI-FIBRILATION EFFECT, THEIR VASCULAR-SPASMOLYTIC EFFECT AND MUSCULAR-SPASMOLYTIC EFFECT, AND AS ANTI-HYPERTENSIVES. AN ALKYLMERCAPTO MOIETY OF 1 TO 4 CARBON ATOMS IN THE ALKYL PORTION, TRIFLUOROMETHYL, CARBOXYL, CARBALKOXY OF 1 TO 4 CARBON ATOMS IN THE ALKOXY PORTION AND AN ALKYLSULPHONYL MOIETY OF 1 TO 4 CARBON ATOMS IN THE ALKYL PORTION; BENZYL; STYRYL; PYRIDYL; PYRIMIDYL; FURYL; THIENYL; PYRROLYL; PYRIDYL, PYRROLYL, THIENYL OR FURYL SUBSTITUTED BY ALKYL OF 1 OR 2 CARBON ATOMS; OR PYRIMIDYL SUBSTITUTED BY AT LEAST ONE MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYL OF 1 OR 2 CARBON ATOMS, 1 OR 2 METHOXY MOIETIES AND 1 OR 2 ETHOXY MOITIES; AND R4 IS STRAIGHT OR BRANCHED CHAIN ALKYL OF 1 TO 4 CARBON ATOMS. (3,4-(-O-CH2-O-)PHENYL)- R IS HYDROGEN, STRAIGHT, BRANCHED OR CYCLIC LOWER ALKYL, LOWER ALKENYL, OR LOWER ALKINYL, UNSUBSTITUTED OR SUBSTITUTED BY HYDROXYL OR ALKOXY OF 1 TO 3 CARBON ATOMS; OR BENZYL, OR PHENETHYL, UNSUBSTITUTED OR SUBSTITUTED IN THE ARYL PORTION BY 1 TO 7 MEMBERS SELECTED FROM THE GROUP CONSISTING OF 1 TO 3 ALKOXY MOIETIES OF 1 TO 3 CARBON ATOMS, 1 OR 2 ALKYL MOIETIES OF 1 TO 3 CARBON ATOMS, AND 1 OR 2 HALOGEN ATOMS; R1 IS STRAIGHT OR BRANCHED CHAIN ALKYL OF 1 TO 4 CARBON ATOMS; R2 IS STRAIGHT OR BRANCHED CHAIN ALKYL OF 1 TO 6 CARBON ATOMS, STRAIGHT OR BRANCHED CHAIN DIALKYL OF 1 TO 6 ATOMS, STRAIGHT OR BRANCHED CHAIN DIALKYL OF 1 TO 6 CARBON ATOMS, STRAIGHT OR BRANCHED CHAIN ALKENYL OF 2 6 CARBON ATOMS, STRAIGHT OR BRANCHED CHAIN ALKINYL OF 2 TO 6 CARBON ATOMS, CYCLIC ALKYL OF 3 TO 6 CARBON ATOMS, CYCLIC ALKENYL OF 3 TO 6 CARBON ATOMS, STRAIGHT OR BRANCHED CHAIN ALKYL OR ALKENYL OF 2 TO 6 CARBON ATOMS INTERRUPTED BY 1 OR 2 OXYGEN ATOMS, STRAIGHT OR BRANCHED CHAIN ALKYL OF 1 TO 6 CARBON ATOMS SUBSTITUTED BY HYDROXYL, OR STRAIGHT OR BRANCHED CHAIN ALKENYL OF 2 TO 6 CARBON ATOMS SUBSTITUTED BY HYDROXYL; R3 IS ARYL, UNSUBSTITUTED OR SUBSTITUTED BY 1 TO 3 MEMBERS SELECTED FROM THE GROUP CONSISTING OF 1 TO 3 NITRO MOIETIES, 1 TO 2 CYANO MOIETIES, 1 TO 3 HALOGEN ATOMS, 1 OR 2 HYDROXYL MOIETIES, 1 OR 2 ACYLOXY MOIETIES OF 1 OR 2 CARBON ATOMS IN THE ACYL PORTION, 1 TO 3 ALKOXY MOIETIES OF U TO 4 CARBON ATOMS, A DIOXYMETHYLENE MOIETY OF THE FORMULA: PYRIDINE

Inventors

• 👤 F Bossert
• 👤 W Vater

Bibliographic Details