US4551452A
Expired / Lapsed
US
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Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
Assignee: Pfizer Inc
•
Filing: 1984-05-02
•
Granted: 1985-11-05
•
Expires: 2004-05-02
Abstract
Abstract Certain enol ether derivatives of oxicams (1,1-dioxides of N-heteroaryl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamides and N-heteroaryl-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamides) are useful as prodrugs of these antiinflammatory compounds.
Inventors
- 👤 Anthony Marfat
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:02
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04; C07C; C07C68/00; C07C68/02; C07D417/00; C07D417/02; C07D417/12; C07D417/14
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
74 words
A compound having the formula ##STR7## wherein R is ##STR8## and R 1 is ##STR9## n is 2, 3 or 4; R 2 is hydrogen, methyl or phenyl; R 4 and R 5 are each independently hydrogen or methyl; R 3 is (C 1- C 10 )alkyl, (C 3 -C 7 )cycloalkyl, phenyl or benzyl, each optionally substituted by OR 6 or OCOR 6 , and R 6 is (C 1 -C 3 )alkyl.
Claim 2
Dependent Claim
74 words
A compound having the formula ##STR7## wherein R is ##STR8## and R 1 is ##STR9## n is 2, 3 or 4; R 2 is hydrogen, methyl or phenyl; R 4 and R 5 are each independently hydrogen or methyl; R 3 is (C 1- C 10 )alkyl, (C 3 -C 7 )cycloalkyl, phenyl or benzyl, each optionally substituted by OR 6 or OCOR 6 , and R 6 is (C 1 -C 3 )alkyl.
Claim 3
Dependent Claim
13 words
A compound of claim 1 having the formula (I) wherein R is ##STR10##
Claim 4
Dependent Claim
10 words
A compound of claim 2 wherein R 1 is ##STR11##
Claim 5
Dependent Claim
15 words
The compound of claim 3 wherein R 2 is methyl and R 3 is ethyl.
Claim 6
Dependent Claim
15 words
The compound of claim 3 wherein R 2 is methyl and R 3 is cyclopropyl.
Claim 7
Dependent Claim
15 words
The compound of claim 3 wherein R 2 is methyl and R 3 is phenyl.
Claim 8
Dependent Claim
15 words
The compound of claim 3 wherein R 2 is hydrogen and R 3 is 2-methyl-2-(methoxycarbonyl)ethyl.
Claim 9
Dependent Claim
10 words
A compound of claim 2 wherein R 1 is ##STR12##
Claim 10
Dependent Claim
15 words
The compound of claim 8 wherein R 2 is methyl and R 3 is ethyl.
Claim 11
Dependent Claim
15 words
The compound of claim 8 wherein R 2 is methyl and R 3 is benzyl.
Claim 12
Dependent Claim
15 words
The compound of claim 8 wherein R 2 is methyl and R 3 is decyl.
Claim 13
Dependent Claim
15 words
The compound of claim 8 wherein R 2 is methyl and R 3 is cyclohexyl.
Claim 14
Dependent Claim
10 words
The compound of claim 2 wherein R 1 is ##STR13##
Claim 15
Dependent Claim
10 words
The compound of claim 2 wherein R 1 is ##STR14##
Claim 16
Dependent Claim
10 words
The compound of claim 2 wherein R 1 is ##STR15##
Claim 17
Dependent Claim
10 words
The compound of claim 2 wherein R 1 is ##STR16##
Claim 18
Dependent Claim
13 words
A compound of claim 1 having the formula (I) wherein R is ##STR17##
Claim 19
Dependent Claim
10 words
The compound of claim 17 wherein R 1 is ##STR18##
Claim 20
Dependent Claim
13 words
A compound of claim 1 having the formula (I) wherein R is ##STR19##
Claim 21
Dependent Claim
10 words
The compound of claim 19 wherein R 1 is ##STR20##
Claim 22
Dependent Claim
10 words
The compound of claim 19 wherein R 1 is ##STR21##
Claim 23
Dependent Claim
10 words
The compound of claim 19 wherein R 1 is ##STR22##
Claim 24
Dependent Claim
13 words
A compound of claim 1 having the formula (II) wherein R is ##STR23##
Claim 25
Dependent Claim
10 words
The compound of claim 23 wherein R 1 is ##STR24##
Claim 26
Dependent Claim
13 words
A compound of claim 1 having the formula (I) wherein R is ##STR25##
Claim 27
Dependent Claim
10 words
The compound of claim 25 wherein R 1 is ##STR26##
Claim 28
Dependent Claim
14 words
An anti-inflammatory composition which comprises an anti-inflammatory amount of a compound of claim 1.
Claim 29
Dependent Claim
23 words
A method of treating inflammatory conditions in a mammal which comprises oral administration of an anti-inflammatory amount of a compound of claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-04 | 1989-05-06 | 1989-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-04 | 1993-05-06 | 1993-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-04 | 1997-05-06 | 1997-11-05 | $7700.00 | Window Closed / Lapsed |