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US4309427A Expired / Lapsed US ⏱️ 0.0 years remaining

Benzothiazine dioxide derivatives

Assignee: Pfizer Inc
•
Filing: 1981-01-15
•
Granted: 1982-01-05
•
Expires: 2001-01-15
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Abstract

Abstract Certain novel derivatives of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared, including N-(2-pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, N-(2-pyridyl)-2-methyl-4-(n-butyryloxy)-2H-1,2-benzothiazine-3-carboxa mide 1,1-dioxide, N-(6-methyl-2-pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carbo xamide 1,1-dioxide, N-(2-pyridyl)-2-methyl-4-benzoyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, N-(6-methyl-2-pyridyl)-2-methyl-4-benzoyloxy-2H-1,2-benzothiazine-3-ca rboxamide 1,1-dioxide, N-(2-pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine-3-car boxamide 1,1-dioxide and N-(6-methyl-2-pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiaz ine-3-carboxamide 1,1-dioxide. All these compounds are useful in therapy as non-steroidal anti-inflammatory agents, especially when administered by the topical route of administration. Methods for preparing these compounds from known starting materials are provided.

Inventors

  • 👤 Joseph G. Lombardino

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-04 19:35
CPC Classifications
C; C07; C07D; C07D417/00; C07D417/02; C07D417/12; A; A61; A61P; A61P29/00

Claims Analysis

Total Claims: 20
Claim 1
Independent Claim 38 words
A compound of the formula: ##STR2## wherein R is selected from the group consisting of alkanoyl having from two to nine carbon atoms, benzoyl, toluoyl, thenoyl, furoyl, lower alkanesulfonyl and benzenesulfonyl, and R 1 is hydrogen or methyl.
Claim 2
Dependent Claim 38 words
A compound of the formula: ##STR2## wherein R is selected from the group consisting of alkanoyl having from two to nine carbon atoms, benzoyl, toluoyl, thenoyl, furoyl, lower alkanesulfonyl and benzenesulfonyl, and R 1 is hydrogen or methyl.
Claim 3
Dependent Claim 16 words
A compound as claimed in claim 1 wherein R is alkanoyl and R 1 is hydrogen.
Claim 4
Dependent Claim 16 words
A compound as claimed in claim 1 wherein R is alkanoyl and R 1 is methyl.
Claim 5
Dependent Claim 16 words
A compound as claimed in claim 1 wherein R is benzoyl and R 1 is hydrogen.
Claim 6
Dependent Claim 16 words
A compound as claimed in claim 1 wherein R is benzoyl and R 1 is methyl.
Claim 7
Dependent Claim 17 words
A compound as claimed in claim 1 wherein R is lower alkanesulfonyl and R 1 is hydrogen.
Claim 8
Dependent Claim 17 words
A compound as claimed in claim 1 wherein R is lower alkanesulfonyl and R 1 is methyl.
Claim 9
Dependent Claim 2 words
N-(2-Pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 10
Dependent Claim 2 words
N-(2-Pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 11
Dependent Claim 2 words
N-(2-Pyridyl)-2-methyl-4-(n-butyryloxy)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 12
Dependent Claim 2 words
N-(2-Pyridyl)-2-methyl-4-(n-butyryloxy)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 13
Dependent Claim 2 words
N-(6-Methyl-2-pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 14
Dependent Claim 2 words
N-(6-Methyl-2-pyridyl)-2-methyl-4-acetoxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 15
Dependent Claim 2 words
N-(2-Pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 16
Dependent Claim 2 words
N-(2-Pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 17
Dependent Claim 2 words
N-(6-Methyl-2-pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 18
Dependent Claim 2 words
N-(6-Methyl-2-pyridyl)-2-methyl-4-methanesulfonyloxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.
Claim 19
Dependent Claim 28 words
A method for treating inflammatory conditions in a warm-blooded animal, which comprises administering to said animal an effective anti-inflammatory amount of a compound as claimed in claim 1.
Claim 20
Dependent Claim 21 words
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective anti-inflammatory amount of a compound as claimed in claim 1.

References Cited (Backward Citations)

US3591584A Cited
US3925371A Cited
US4116964A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-01-04 1985-07-06 1986-01-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-01-04 1989-07-06 1990-01-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-01-04 1993-07-06 1994-01-05 $7700.00 Window Closed / Lapsed

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