Patent US4551282A successfully refreshed from Google Patents.
US4551282A
Expired / Lapsed
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Triphenylene derivatives
Assignee: SmithKline Beecham Corp
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Filing: 1983-05-31
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Granted: 1985-11-05
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Expires: 2003-05-31
Abstract
Abstract The present invention relates to compounds of formula (I) ##STR1## wherein Ar is a triphenylene or substituted triphenylene ring system; R 1 is a C 1-3 alkylene moiety; R 2 is hydrogen or a C 1-6 alkyl group; R 3 is a hydroxy C 1-6 alkyl group; R 4 and R 5 are the same or different and are hydrogen, C 1-6 alkyl or hydroxy C 1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R 3 , R 4 , and R 5 ; Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.
Inventors
- 👤 Kenneth W. Bair
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:46
CPC Classifications
C; C07; C07C; C07C47/00; C07C47/52; C07C47/546; C07C45/00; C07C45/51; C07C45/511; C07C45/513
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
108 words
A compound of formula (I) ##STR8## wherein Ar is a triphenylene or a triphenylene ring system substituted with halogen, C 1-6 alkyl, C 1-6 alkoxy, halo C 1-6 alkyl, C 1-6 alkylthio, hydroxy C 1-6 alkyl, hydroxy C 1-6 alkylthio, cyano, C 1-6 alkylsulphinyl or C 1-6 alkylsulphenyl; R 1 is a C 1-3 alkylene moiety, R 2 is hydrogen or a C 1-6 alkyl group; R 3 is a hydroxxy C 1-6 alkyl group; and R 4 and R 5 are the same or different and are hydrogen, C 1-6 alkyl groups or hydroxy C 1-6 alkyl group, or a C 1-6 alkyl carboxylic acid ester thereof.
Claim 2
Dependent Claim
108 words
A compound of formula (I) ##STR8## wherein Ar is a triphenylene or a triphenylene ring system substituted with halogen, C 1-6 alkyl, C 1-6 alkoxy, halo C 1-6 alkyl, C 1-6 alkylthio, hydroxy C 1-6 alkyl, hydroxy C 1-6 alkylthio, cyano, C 1-6 alkylsulphinyl or C 1-6 alkylsulphenyl; R 1 is a C 1-3 alkylene moiety, R 2 is hydrogen or a C 1-6 alkyl group; R 3 is a hydroxxy C 1-6 alkyl group; and R 4 and R 5 are the same or different and are hydrogen, C 1-6 alkyl groups or hydroxy C 1-6 alkyl group, or a C 1-6 alkyl carboxylic acid ester thereof.
Claim 3
Dependent Claim
25 words
A compound of claim 1 which is 2-methyl-2-((2-triphenylenylmethyl)amino)-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
10 words
The hydrochloric acid salt of the compound of claim 2.
Claim 5
Dependent Claim
10 words
The hydrochloric acid salt of a compound of claim 1.
Claim 6
Dependent Claim
10 words
The citric acid salt of a compound of claim 1.
Claim 7
Dependent Claim
9 words
The acetic salt of a compound of claim 1.
Claim 8
Dependent Claim
10 words
The methanesulfonic acid salt of a compound of claim 1.
Claim 9
Dependent Claim
1 words
2-Methyl-2-((2-triphenylenylmethyl)amino)-1,3-propanediol.
Claim 10
Dependent Claim
1 words
2-Methyl-2-((2-triphenylenylmethyl)amino)-1,3-propanediol.
Claim 11
Dependent Claim
8 words
A pharmaceutically acceptable acid addition salt of 2-methyl-2-((2-triphenylenylmethyl)amino)-1,3-propanediol.
Claim 12
Dependent Claim
8 words
A pharmaceutically acceptable acid addition salt of 2-methyl-2-((2-triphenylenylmethyl)amino)-1,3-propanediol.
References Cited (Backward Citations)
US3344155A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-04 | 1989-05-06 | 1989-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-04 | 1993-05-06 | 1993-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-04 | 1997-05-06 | 1997-11-05 | $7700.00 | Window Closed / Lapsed |