US4550109A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lipoidal biopterin compounds
Assignee: The University of Texas System
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Filing: 1984-05-31
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Granted: 1985-10-29
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Expires: 2004-05-31
Abstract
Abstract The present invention provides lipoidal biopterin and tetrahydrobiopterin compounds of the general structure: <IMAGE> wherein -R is absent when ring B has two double bonds, -R is hydrogen when the two double bonds in ring B are absent, and -R' and R'' are selected from saturated or unsaturated, cyclic or non-cyclic hydrocarbons of 1 to 31 carbon units. The compounds provided by this invention are oil soluble and can readily be formulated as an oil based pharmaceutical useful for the treatment of phenylketonuria, Parkinsonism, depression, senile dementia, Alzheimer's disease and related biopterin deficiency diseases.
Inventors
- 👤 Karl Folkers
- 👤 Klaus P. Laesecke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 18:35
CPC Classifications
C; C07; C07D; C07D475/00; C07D475/02; C07D475/04; A; A61; A61P; A61P25/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
79 words
A lipoidal compound having the formula: ##STR5## wherein --R is absent when there are two double bonds in ring B; --R is hydrogen when the two double bonds in ring B are absent; and --R' and R" are independently saturated or unsaturated, aliphatic hydrocarbon groups which are balanced in molecular weight such that they confer to the lipoidal compound a lipoidal property, and wherein --R' has 8 to 19 carbon units and --R" has 1 to 3 carbon units.
Claim 2
Dependent Claim
79 words
A lipoidal compound having the formula: ##STR5## wherein --R is absent when there are two double bonds in ring B; --R is hydrogen when the two double bonds in ring B are absent; and --R' and R" are independently saturated or unsaturated, aliphatic hydrocarbon groups which are balanced in molecular weight such that they confer to the lipoidal compound a lipoidal property, and wherein --R' has 8 to 19 carbon units and --R" has 1 to 3 carbon units.
Claim 3
Dependent Claim
8 words
The compound of claim 1 which is 2-N-stearoyl-1',2'-di-O-acetyl-biopterin.
Claim 4
Dependent Claim
8 words
The compound of claim 1 which is 2-N-stearoyl-1',2'-di-O-acetyl-5,6,7,8,-tetrahydrobiopterin.
Claim 5
Dependent Claim
11 words
The compound of claim 1 which is 2-N-decanoyl-1',2'-di-O-acetyl-L-biopterin, 2-N-palmitoyl-1',2'-di-O-acetyl-L-biopterin, or 2-N-linoleyl-1',2'-di-O-acetyl-L-biopterin.
Claim 6
Dependent Claim
11 words
The compound of claim 1 which is 2-N-decanoyl-1',2'-di-O-acetyl-5,6,7,8,-tetraphydrobiopterin, 2-N-palmitoyl-1',2'-di-O-acetyl-5,6,7,8,-tetrahydrobiopterin, or 2-N-linoleyl-1',2'-di-O-acetyl-5,6,7,8,-tetrahydrobiopterin.
Claim 7
Dependent Claim
26 words
A pharmaceutical composition useful for treating brain-related biopterin deficiencies which comprises a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of claim 1.
Claim 8
Dependent Claim
28 words
A method of treating brain-related biopterin deficiencies which comprises administering to a patient in need of such treatment a pharmaceutically effective amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-10-28 | 1989-04-29 | 1989-10-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-10-28 | 1993-04-29 | 1993-10-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-10-28 | 1997-04-29 | 1997-10-29 | $7700.00 | Window Closed / Lapsed |