US4542168A
Expired / Lapsed
US
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Denture fixative composition with partially neutralized and crosslinked polyacrylic acid
Assignee: Block Drug Co Inc
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Filing: 1984-02-06
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Granted: 1985-09-17
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Expires: 2004-02-06
Abstract
Abstract A denture fixative composition contains as the active fixative a partially neutralized and crosslinked polyacrylic acid or a precursor combination of the polyacrylic acid, neutralizing agent(s) and crosslinking agent(s) which is adapted to form the active fixative, and at least one hydrophilic polymer, preferably, sodium carboxymethyl cellulose, hydroxypropyl guar or sodium alginate.
Inventors
- 👤 Tiang-Shing Chang
- 👤 Lucy J. Zientek
- 👤 Arthur Viningauz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 01:45
CPC Classifications
A; A61; A61K; A61K6/00; A61K6/30; A61K6/35
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
195 words
A denture fixative composition which develops when contacted with saliva a high degree of tack and viscous mucilage which spreads over the denture-mucosa interface to fill the gaps therebetween and resists the stresses of mastication, comprising a dentally acceptable excipient and an effective denture fixative amount of a combination of (a) polyacrylic acid which has been partially neutralized by at least one monovalent cation and partially crosslinked by at least one agent selected from the group consisting of the salts, bases and oxides of divalent cations and polyhydroxy compounds such that 20-90% of the initial carboxyl groups have been neutralized or crosslinked, wherein a 1% aqueous solution of said partially neutralized and crosslinked polyacrylic acid has a pH of at least about 4.5, or a precursor combination of polyacrylic acid, neutralizing agent and crosslinking agent or of partially neutralized polyacrylic acid and crosslinking agent or of partially crosslinked polyacrylic acid and neutralizing agent, said precursor combination adapted to form said partially neutralized and crosslinked polyacrylic acid in an aqueous environment, and (b) at least one hydrophilic polymer selected from the group consisting of guar, alginate, karaya and xanthan gums, sodium carboxymethyl cellulose, and methyl cellulose.
Claim 2
Dependent Claim
195 words
A denture fixative composition which develops when contacted with saliva a high degree of tack and viscous mucilage which spreads over the denture-mucosa interface to fill the gaps therebetween and resists the stresses of mastication, comprising a dentally acceptable excipient and an effective denture fixative amount of a combination of (a) polyacrylic acid which has been partially neutralized by at least one monovalent cation and partially crosslinked by at least one agent selected from the group consisting of the salts, bases and oxides of divalent cations and polyhydroxy compounds such that 20-90% of the initial carboxyl groups have been neutralized or crosslinked, wherein a 1% aqueous solution of said partially neutralized and crosslinked polyacrylic acid has a pH of at least about 4.5, or a precursor combination of polyacrylic acid, neutralizing agent and crosslinking agent or of partially neutralized polyacrylic acid and crosslinking agent or of partially crosslinked polyacrylic acid and neutralizing agent, said precursor combination adapted to form said partially neutralized and crosslinked polyacrylic acid in an aqueous environment, and (b) at least one hydrophilic polymer selected from the group consisting of guar, alginate, karaya and xanthan gums, sodium carboxymethyl cellulose, and methyl cellulose.
Claim 3
Dependent Claim
46 words
The denture fixative composition of claim 1 wherein said polyacrylic acid has an average molecular weight of about 500,000-5,000,000, said divalent cation is an alkaline earth metal cation, said polyhydroxy compound has 2 to 6 carbon atoms and said monovalent cation is an alkali metal cation.
Claim 4
Dependent Claim
42 words
The denture fixative composition of claim 2 wherein said polyacrylic acid has an average molecular weight of about 2,000,000-4,000,000, said monovalent cation is sodium or potassium, said divalent cation is magnesium or calcium and said polyhydroxy compound is glycerin or propylene glycol.
Claim 5
Dependent Claim
41 words
The denture fixative composition of claim 2 wherein the amount of neutralizing agent is sufficient to neutralize about 10-70% of the initial carboxyl groups and the amount of crosslinking agent is sufficient to crosslink about 10-80% of the initial carboxyl groups.
Claim 6
Dependent Claim
48 words
The denture fixative composition of claim 4 wherein said neutralizing agent is in an amount sufficient to neutralize 10-50% of the initial carboxyl groups when said crosslinking agent is said divalent cation and about 20-60% of said initial carboxyl groups when said crosslinking agent is said polyhydroxy compound.
Claim 7
Dependent Claim
38 words
The denture fixative composition of claim 4 wherein the ratio of monovalent cation to divalent cation is about 1:4-4:1 and the amount of polyhydroxy compound is sufficient to react with up to 30% of the initial carboxyl groups.
Claim 8
Dependent Claim
17 words
The denture fixative composition of claim 4 wherein said fixative is about 10-70 wt.% of said composition.
Claim 9
Dependent Claim
26 words
The denture fixative composition of claim 4 wherein a 1% aqueous solution of said partially neutralized and crosslinked polyacrylic acid has a pH of about 5.0-7.0.
Claim 10
Dependent Claim
14 words
The denture fixative composition of claim 4 wherein said fixative is said precursor combination.
Claim 11
Dependent Claim
26 words
The denture fixative composition of claim 4 wherein said fixative is said precursor combination and said precursor combination comprises partially neutralized polyacrylic acid and crosslinking agent.
Claim 12
Dependent Claim
19 words
The denture fixative composition of claim 1 wherein said hydrophilic polymer is carboxymethyl cellulose, hydroxypropyl guar or sodium alginate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-16 | 1989-03-18 | 1989-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-16 | 1993-03-18 | 1993-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-16 | 1997-03-18 | 1997-09-17 | $7700.00 | Window Closed / Lapsed |