Patent US4542013A successfully refreshed from Google Patents.
US4542013A
Expired / Lapsed
US
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Trinitroglycerol sustained release vehicles and preparation therefrom
Assignee: Key Pharmaceuticals Inc
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Filing: 1983-08-16
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Granted: 1985-09-17
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Expires: 2003-08-16
Abstract
Abstract A trinitroglycerol-containing substantially disaccharide-free polymeric diffusion matrix is provided for the transdermal systemic delivery of trinitroglycerol through the skin of a patient. The polymeric diffusion matrix contains sufficient trinitroglycerol to be released over a prolonged period of time and comprises a first lower molecular weight, partially hydrolyzed polyvinylalcohol component, a second higher molecular weight, essentially fully hydrolyzed polyvinylalcohol component, and glycerol.
Inventors
- 👤 Alec D. Keith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 15:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K31/00; A61K31/21; A61K9/0012; A61K9/0053; A61K9/006; A61K9/14; A61K9/141; A61K9/146
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
171 words
A polymeric diffusion matrix for the transdermal systemic delivery of polymeric fixed dimension gelled trinitroglycerol through the skin of a patient comprising about 10 to about 40% of a first lower molecular weight polyvinylalcohol component that is hydrolyzed to a degree of hydrolysis of about 75 to about 92% and has a molecular weight in the range of from about 5,000 to about 40,000; about 2% to about 15% of a second higher molecular weight polyvinylalcohol component that is hydrolyzed to a degree of hydrolysis of at least 95% and has a molecular weight in the range of from about 90,000 to about 150,000; and about 2 to about 25% of glycerol, said polymeric diffusion matrix containing sufficient substantially disaccharide-free trinitroglycerol bound to a polymer as a triturate in a non-explosive flowable fixed dimension gel form, said polymer being selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyethylene glycol, polymethacrylate, polymethyl methacrylate, ethyl acrylate-vinyl chloride polymer, and mixtures thereof to be released over a prolonged period of time.
Claim 2
Dependent Claim
171 words
A polymeric diffusion matrix for the transdermal systemic delivery of polymeric fixed dimension gelled trinitroglycerol through the skin of a patient comprising about 10 to about 40% of a first lower molecular weight polyvinylalcohol component that is hydrolyzed to a degree of hydrolysis of about 75 to about 92% and has a molecular weight in the range of from about 5,000 to about 40,000; about 2% to about 15% of a second higher molecular weight polyvinylalcohol component that is hydrolyzed to a degree of hydrolysis of at least 95% and has a molecular weight in the range of from about 90,000 to about 150,000; and about 2 to about 25% of glycerol, said polymeric diffusion matrix containing sufficient substantially disaccharide-free trinitroglycerol bound to a polymer as a triturate in a non-explosive flowable fixed dimension gel form, said polymer being selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl acetate, polyethylene glycol, polymethacrylate, polymethyl methacrylate, ethyl acrylate-vinyl chloride polymer, and mixtures thereof to be released over a prolonged period of time.
Claim 3
Dependent Claim
29 words
The polymeric diffusion matrix of claim 1 further comprising up to about two percent by weight of polyvinylpyrrolidone having a molecular weight of from about 20,000 to about 60,000.
Claim 4
Dependent Claim
22 words
The polymeric diffusion matrix of claim 1 further comprising an alkanolamide present in an amount of up to about 5% by weight.
Claim 5
Dependent Claim
24 words
The polymeric diffusion matrix of claim 3, wherein said alkanolamide is present in an amount of from about 0.1 to about 3% by weight.
Claim 6
Dependent Claim
74 words
The polymeric diffusion matrix of claim 1, 3, 2, 3, or 4, further comprising a backing layer adhered to one surface of said polymeric diffusion matrix, said backing layer having a larger surface area than said polymeric diffusion matrix, and an adhesive layer attached to said backing layer on the same side thereof as said polymeric diffusion matrix, whereby said polymeric diffusion matrix is maintained in diffusional contact with the skin of said patient.
Claim 7
Dependent Claim
34 words
The polymeric diffusion matrix of claim 1, 3, 2, 3, or 4, further comprising a facestock layer with skin adhesive which permits the self-adhesion of said polymeric matrix to the skin of said patient.
Claim 8
Dependent Claim
26 words
The polymeric diffusion matrix of claim 1, wherein said first lower molecular weight component is hydrolyzed to a degree of hydrolysis of about 86 to 90%.
Claim 9
Dependent Claim
24 words
The polymeric diffusion matrix of claim 7, wherein said second higher molecular weight component has a degree of hydrolysis of about 98 to 99%.
References Cited (Backward Citations)
US4291015A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-16 | 1989-03-18 | 1989-09-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-16 | 1993-03-18 | 1993-09-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-16 | 1997-03-18 | 1997-09-17 | $7700.00 | Window Closed / Lapsed |