US4540788A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones
Assignee: Wyeth Holdings LLC
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Filing: 1983-07-14
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Granted: 1985-09-10
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Expires: 2003-07-14
Abstract
Abstract This disclosure describes novel Schiff bases of 1,4-bis[( omega -aminoalkyl)amino]-9,10-anthracenediones and leuco bases thereof which are useful as chelating agents and for inducing regression of leukemia and/or inhibiting tumor growth in mammals.
Inventors
- 👤 Keith C. Murdock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 19:29
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/44; C07D213/53; A; A61; A61P; A61P35/00; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/52; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/22
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
109 words
A compound of the formula: ##STR24## wherein n is 2 or 3; R is hydrogen or hydroxy; R 1 is hydrogen or alkyl(C 1 -C 3 ); R 2 is hydrogen, alkyl(C 1 -C 6 ), 1-naphthyl, 2-naphthyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pentafluorophenyl or a moiety of the formula: ##STR25## wherein R 3 and R 4 may be the same or different and are each hydrogen, hydroxy, fluoro, chloro, bromo, cyano, trifluoromethyl, alkyl(C 1 -C 3 ), alkoxy(C 1 -C 3 ), dimethylamino or benzyloxy; and R 1 and R 2 taken together is --(CH 2 ) m -- wherein m is 4, 5 or 6.
Claim 2
Dependent Claim
109 words
A compound of the formula: ##STR24## wherein n is 2 or 3; R is hydrogen or hydroxy; R 1 is hydrogen or alkyl(C 1 -C 3 ); R 2 is hydrogen, alkyl(C 1 -C 6 ), 1-naphthyl, 2-naphthyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pentafluorophenyl or a moiety of the formula: ##STR25## wherein R 3 and R 4 may be the same or different and are each hydrogen, hydroxy, fluoro, chloro, bromo, cyano, trifluoromethyl, alkyl(C 1 -C 3 ), alkoxy(C 1 -C 3 ), dimethylamino or benzyloxy; and R 1 and R 2 taken together is --(CH 2 ) m -- wherein m is 4, 5 or 6.
Claim 3
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(pentafluorophenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 4
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(phenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 5
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(1-naphthylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 6
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(2,4-dimethoxyphenylmethyleneamino)ethylamino]-5,-8-dihydroxy-9,10-anthracenedione.
Claim 7
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(2-furylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 8
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(4-fluorophenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 9
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(3-pyridylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 10
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(3-methylphenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 11
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(3-trifluoromethylphenylmethylenamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 12
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(4-benzyloxyphenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 13
Dependent Claim
7 words
The compound according to claim 1; 1,4-bis[2-(4-dimethyaminophenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 14
Dependent Claim
7 words
The compound according to claim 1, 1,4-bis[2-(4-methoxyphenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 15
Dependent Claim
7 words
The compound according to claim 1, 1,4-bis[2-(2-pyridylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 16
Dependent Claim
7 words
The compound according to claim 1, 1,4-bis[2(4-cyanophenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
Claim 17
Dependent Claim
7 words
The compound according to claim 1, 1,4-bis[2(3,5-dimethoxyphenylmethyleneamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione.
References Cited (Backward Citations)
US4197249A
Cited
US4258181A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-09 | 1989-03-11 | 1989-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-09 | 1993-03-11 | 1993-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-09 | 1997-03-11 | 1997-09-10 | $7700.00 | Window Closed / Lapsed |