US4197249A
Expired / Lapsed
US
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1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
Assignee: Wyeth Holdings LLC
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Filing: 1978-07-11
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Granted: 1980-04-08
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Expires: 1998-07-11
Abstract
Abstract This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
Inventors
- 👤 Keith C. Murdock
- 👤 Frederick E. Durr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
111 words
A compound selected from the group consisting of those of the formula: ##STR11## wherein Q is a divalent moiety selected from the group consisting of those of the formulae: ##STR12## wherein n is an integer from 2 to 4, inclusive; R 1 and R 2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group with the proviso that R 1 and R 2 may not both be hydrogen or alkyl; and the pharmacologically acceptable acid-addition salts thereof.
Claim 2
Dependent Claim
111 words
A compound selected from the group consisting of those of the formula: ##STR11## wherein Q is a divalent moiety selected from the group consisting of those of the formulae: ##STR12## wherein n is an integer from 2 to 4, inclusive; R 1 and R 2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atom alpha to the nitrogen atom may not bear an hydroxy group with the proviso that R 1 and R 2 may not both be hydrogen or alkyl; and the pharmacologically acceptable acid-addition salts thereof.
Claim 3
Dependent Claim
114 words
A compound selected from the group consisting of those of the formula: ##STR13## wherein Q is a divalent moiety selected from the group consisting of those of the formulae: ##STR14## wherein n is an integer from 2 to 4, inclusive; R 1 and R 2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atoms alpha to the nitrogen atom may not bear an hydroxy group with the proviso that R 1 and R 2 may not both be hydrogen or alkyl; the tautomers thereof; and the pharmacologically acceptable acid-addition salts thereof.
Claim 4
Dependent Claim
114 words
A compound selected from the group consisting of those of the formula: ##STR13## wherein Q is a divalent moiety selected from the group consisting of those of the formulae: ##STR14## wherein n is an integer from 2 to 4, inclusive; R 1 and R 2 are each individually selected from the group consisting of hydrogen, alkyl having from 1 to 4 carbon atoms and monohydroxyalkyl having from 2 to 4 carbon atoms and wherein the carbon atoms alpha to the nitrogen atom may not bear an hydroxy group with the proviso that R 1 and R 2 may not both be hydrogen or alkyl; the tautomers thereof; and the pharmacologically acceptable acid-addition salts thereof.
Claim 5
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is sulfuric acid.
Claim 6
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is phosphoric acid.
Claim 7
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is hydrochloric acid.
Claim 8
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is hydrobromic acid.
Claim 9
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is sulfamic acid.
Claim 10
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is citric acid.
Claim 11
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is lactic acid.
Claim 12
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is malic acid.
Claim 13
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is succinic acid.
Claim 14
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is tartaric acid.
Claim 15
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is acetic acid.
Claim 16
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is benzoic acid.
Claim 17
Dependent Claim
13 words
An acid-addition salt according to claim 1 wherein the acid is gluconic acid.
Claim 18
Dependent Claim
13 words
An acid-addition salt according to claim 2 wherein the acid is ascorbic acid.
Claim 19
Dependent Claim
26 words
The compound according to claim 1 wherein Q is ethylene and R 1 and R 2 are both β-hydroxyethyl and in the aromatic free base form.
Claim 20
Dependent Claim
25 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the disuccinate salt form.
Claim 21
Dependent Claim
25 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the dihydrochloride salt form.
Claim 22
Dependent Claim
25 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is 3-hydroxypropyl and in the dihydrobromide salt form.
Claim 23
Dependent Claim
25 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is 2-hydroxypropyl and in the disuccinate salt form.
Claim 24
Dependent Claim
25 words
The compound according to claim 1 wherein Q is trimethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the diacetate salt form.
Claim 25
Dependent Claim
29 words
The compound according to claim 1 wherein Q is --CH 2 CH(CH 3 )--, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the dimalate salt form.
Claim 26
Dependent Claim
26 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the aromatic free base form.
Claim 27
Dependent Claim
13 words
A compound according to claim 24 in its pharmacologically acceptable acid-addition salt form.
Claim 28
Dependent Claim
25 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the digluconate salt form.
Claim 29
Dependent Claim
25 words
The compound according to claim 1 wherein Q is ethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the dibenzoate salt form.
Claim 30
Dependent Claim
26 words
The compound according to claim 2 wherein Q is ethylene, R 1 is hydrogen, and R 2 is β-hydroxyethyl and in the leuco free base form.
Claim 31
Dependent Claim
26 words
The compound according to claim 2 wherein Q is ethylene, R 1 is hydrogen, and R 2 is 2-hydroxypropyl and in the leuco free base form.
References Cited (Backward Citations)
US3646072A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-08 | 1983-10-08 | 1984-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-08 | 1987-10-08 | 1988-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-08 | 1991-10-08 | 1992-04-08 | $7700.00 | Window Closed / Lapsed |