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US4540686A
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3-Keto-19-nor-Δ4,9 -steroids
Assignee: Sanofi Aventis France
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Filing: 1984-06-08
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Granted: 1985-09-10
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Expires: 2004-06-08
Abstract
Abstract Novel 3-keto-19-nor-Δ 4 ,9 -steroids of the formula ##STR1## possessing a remarkable antiglucocorticoidal activity.
Inventors
- 👤 Daniel Philibert
- 👤 Jean G. Teutsch
- 👤 Germain Costerousse
- 👤 Roger Deraedt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 07:56
CPC Classifications
C; C07; C07J; C07J1/00; C07J1/0051; C07J1/0081; C07J1/0088; C07J1/0096; C07J61/00; A; A61; A61P; A61P5/00; A61P5/38; C07J17/00; C07J21/00; C07J21/005; C07J21/006; C07J31/00; C07J31/006; C07J33/00; C07J33/002; C07J41/00; C07J41/0005; C07J41/0016; C07J41/0033; C07J41/0077; C07J41/0083; C07J41/0094; C07J51/00; C07J7/00; C07J7/0005; C07J7/001; C07J7/0015; C07J7/0025; C07J7/003; C07J7/004; C07J7/0045; C07J7/0065; C07J7/0075; C07J71/00; C07J71/0005; C07J71/001
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
65 words
A compound of the formula ##STR21## wherein R 1 is phenyl optionally substituted with at least one member of the group consisting of chlorine, fluorine, methylthio, methylsulfonyl, methoxy, hydroxy and allyloxy and R 4 is selected from the group consisting of ethynyl and propynyl with the proviso that when R 4 is ethynyl, R 1 is not phenyl or phenyl substituted with fluorine or methoxy.
Claim 2
Dependent Claim
65 words
A compound of the formula ##STR21## wherein R 1 is phenyl optionally substituted with at least one member of the group consisting of chlorine, fluorine, methylthio, methylsulfonyl, methoxy, hydroxy and allyloxy and R 4 is selected from the group consisting of ethynyl and propynyl with the proviso that when R 4 is ethynyl, R 1 is not phenyl or phenyl substituted with fluorine or methoxy.
Claim 3
Dependent Claim
13 words
A compound of claim 1 wherein R 1 is phenyl substituted with allyloxy.
Claim 4
Dependent Claim
10 words
A compound of claim 1 wherein R 4 is ethynyl.
Claim 5
Dependent Claim
10 words
A compound of claim 2 wherein R 4 is ethynyl.
Claim 6
Dependent Claim
10 words
A compound of claim 1 wherein R 4 is propynyl.
Claim 7
Dependent Claim
10 words
A compound of claim 2 wherein R 4 is propynyl.
Claim 8
Dependent Claim
11 words
A compound of claim 1 which is 11β-[3-(2-propenyloxy)phenyl]-17α-(prop-1-ynyl)-Δ 4 ,9 -estradiene-17β-ol-3-one.
Claim 9
Dependent Claim
26 words
A method of inducing antiprogestomimetic activity in warm-blooded animals comprising administering to warm-blooded animals an antiprogestiomimetically effective amount of at least one compound of claim 1.
Claim 10
Dependent Claim
13 words
The method of claim 8 wherein R 1 is phenyl substituted with allyloxy.
Claim 11
Dependent Claim
10 words
The method of claim 8 wherein R 4 is ethynyl.
Claim 12
Dependent Claim
10 words
The method of claim 8 wherein R 4 is propynyl.
Claim 13
Dependent Claim
10 words
The method of claim 9 wherein R 4 is ethynyl.
Claim 14
Dependent Claim
10 words
The method of claim 9 wherein R 4 is propynyl.
Claim 15
Dependent Claim
13 words
The method of claim 8 wherein the compound is 11β-[3-(2-propenyloxy)phenyl]-17α-(prop-1-ynyl)-Δ 4 ,9 -estradiene-17β-ol-3-one.
Claim 16
Dependent Claim
16 words
An antiprogestomimetic composition comprising an antiprogestiomimetically effective amount of at least one compound of claim 1.
Claim 17
Dependent Claim
13 words
A composition of claim 15 wherein R 1 is phenyl substituted with allyloxy.
Claim 18
Dependent Claim
10 words
A composition of claim 15 wherein R 4 is ethynyl.
Claim 19
Dependent Claim
10 words
A composition of claim 16 wherein R 4 is ethynyl.
Claim 20
Dependent Claim
10 words
A composition of claim 15 wherein R 4 is propynyl.
Claim 21
Dependent Claim
10 words
A composition of claim 16 wherein R 4 is propynyl.
References Cited (Backward Citations)
DE2801416A1
Cited
US4233296A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-09 | 1989-03-11 | 1989-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-09 | 1993-03-11 | 1993-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-09 | 1997-03-11 | 1997-09-10 | $7700.00 | Window Closed / Lapsed |