Parenteral dispensing system with programmable drug administration

Claim 2

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid, II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal space; (b) means in the wall for (1) releasably connecting the electrotransport apparatus to the parenteral system, for (2) letting pharmaceutical fluid flow from the parenteral system with the electrotransport apparatus, and for (3) letting pharmaceutical fluid exit the electrotransport apparatus and reenter the parenteral system; (c) a pair of electrodes in spaced relation disposed within the electrotransport apparatus; (d) a cation exchange membrane interposed between the electrodes; and, (e) a beneficial agent in the housing initially present between an electrode and the cation exchange membrane.

Claim 3

The parenteral delivery system for administering the beneficial agent according to claim 1, wherein the parenteral delivery system comprises a drug chamber.

Claim 4

The parenteral delivery system for administering the beneficial agent according to claim 1, wherein the beneficial agent is an intravenously administrable drug.

Claim 5

The parenteral delivery system for administering the beneficial agent according to claim 1, wherein the electrodes are connected to an electrical power source.

Claim 6

The parenteral delivery system for administering the beneficial agent according to claim 1, wherein the electrotransport apparatus comprises a fluid passageway in the housing extending from the fluid inlet in the wall to the fluid outlet in the wall.

Claim 7

The parenteral delivery system for administering the beneficial agent according to claim 5, wherein an electrode is disposed in the fluid passageway.

Claim 8

The parenteral delivery system for administering the beneficial agent according to claim 5, wherein the electrotransport apparatus comprises an additional cation exchange membrane and the fluid passageway is interposed between the two cation exchange membranes.

Claim 9

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid; II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal space; (b) an inlet in the wall for letting fluid from the parenteral system enter the electrotransport apparatus; (c) an outlet in the wall for letting fluid from the electrotransport apparatus exit the electrotransport apparatus and reenter the parenteral system; (d) a pair of electrodes in spaced-apart relation positioned within the electrotransport apparatus; (e) an anion exchange membrane interposed between the electrodes; and, (f) a beneficial agent in the housing between an electrode and the anion exchange membrane.

Claim 10

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid; II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal space; (b) an inlet in the wall for letting fluid from the parenteral system enter the electrotransport apparatus; (c) an outlet in the wall for letting fluid from the electrotransport apparatus exit the electrotransport apparatus and reenter the parenteral system; (d) a pair of electrodes in spaced-apart relation positioned within the electrotransport apparatus; (e) an anion exchange membrane interposed between the electrodes; and, (f) a beneficial agent in the housing between an electrode and the anion exchange membrane.

Claim 11

The parenteral delivery system for administering the beneficial agent according to claim 8, wherein the parenteral delivery system comprises a drip chamber.

Claim 12

The parenteral delivery system for administering the beneficial agent according to claim 8, wherein the beneficial agent is an intravenously administrable drug.

Claim 13

The parenteral delivery system for administering the beneficial agent according to claim 8, wherein the electrodes are connected to an electrical power source.

Claim 14

The parenteral delivery system for administering the beneficial agent according to claim 8, wherein a fluid passageway is in the housing extending from the fluid inlet to the fluid outlet.

Claim 15

The parenteral delivery system for administering the beneficial agent according to claim 11, wherein an electrode is disposed in the fluid passageway.

Claim 16

The parenteral delivery system for administering the beneficial agent according to claim 11, wherein an additional anion exchange membrane is present in the electrotransport apparatus and the passageway is located between the two anion exchange membranes.

Claim 17

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid; II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal lumen; (b) an inlet in the wall adapted for releasably connecting the electrotransport apparatus to the parenteral system; (c) an outlet in the wall adapted for connecting the electrotransport apparatus to the parenteral system; (d) a porous body in the housing, the porous body comprising a fluid entrance surface, a fluid exit surface, and being capable of carrying a surface charge; (e) a pair of electrodes in the housing placed on each side of the porous body; and, (f) a beneficial agent in the housing between an electrode and the fluid entrance surface of the porous body.

Claim 18

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid; II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal lumen; (b) an inlet in the wall adapted for releasably connecting the electrotransport apparatus to the parenteral system; (c) an outlet in the wall adapted for connecting the electrotransport apparatus to the parenteral system; (d) a porous body in the housing, the porous body comprising a fluid entrance surface, a fluid exit surface, and being capable of carrying a surface charge; (e) a pair of electrodes in the housing placed on each side of the porous body; and, (f) a beneficial agent in the housing between an electrode and the fluid entrance surface of the porous body.

Claim 19

The parenteral delivery system for administering a beneficial agent according to claim 14, wherein the parenteral system comprises a drip chamber.

Claim 20

The parenteral delivery system for administering a beneficial agent according to claim 14, wherein the beneficial agent is an intravenously administrable drug.

Claim 21

The parenteral delivery system for administering a beneficial agent according to claim 14, wherein the electrodes are connected to an electrical power source.

Claim 22

The parenteral delivery system for administering the beneficial agent according to claim 14, wherein a fluid passageway is in the housing extending from the fluid inlet to the fluid outlet.

Claim 23

The parenteral delivery system for administering the beneficial agent according to claim 18, wherein an electrode is in the fluid passageway.

Claim 24

The parenteral delivery system for administering the beneficial agent according to claim 18, wherein an ion exchange membrane is in the housing and a passageway is positioned between the porous body and the ion exchange membrane.

Claim 25

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid; II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal lumen; (b) an inlet in the wall for connecting the electrotransport apparatus to the parenteral system; (c) an outlet in the wall for connecting the electrotransport apparatus to the parenteral system; (d) a pair of spaced electrodes within the lumen; (e) a porous body and an ion exchange member within the lumen and disposed between the electrodes, said body being capable of carrying a surface charge; (f) a fluid passageway in the lumen, said passageway extending from the inlet to the outlet and interposed between the porous body and the ion exchange member; and, (g) a beneficial agent in the lumen between the electrode, the porous body and the ion exchange member.

Claim 26

A parenteral delivery system for administering a beneficial agent to a recipient, the delivery system comprising: I. a reservoir of a pharmaceutical fluid; II. an electrotransport apparatus for use with the parenteral system for admitting a beneficial agent into the pharmaceutical fluid, the electrotransport apparatus comprising: (a) a housing comprising a wall that surrounds an internal lumen; (b) an inlet in the wall for connecting the electrotransport apparatus to the parenteral system; (c) an outlet in the wall for connecting the electrotransport apparatus to the parenteral system; (d) a pair of spaced electrodes within the lumen; (e) a porous body and an ion exchange member within the lumen and disposed between the electrodes, said body being capable of carrying a surface charge; (f) a fluid passageway in the lumen, said passageway extending from the inlet to the outlet and interposed between the porous body and the ion exchange member; and, (g) a beneficial agent in the lumen between the electrode, the porous body and the ion exchange member.

Claim 27

The parenteral delivery system for administering the beneficial agent according to claim 22 wherein the parenteral delivery system comprises a drip chamber.

Claim 28

The parenteral delivery system for administering the beneficial agent according to claim 22, wherein the electrodes are connected to an electrical power source.

Claim 29

The parenteral delivery system for administering the beneficial agent according to claim 22, wherein the internal lumen contains a fluid containing an electrolyte that is a intravenous carrier for the beneficial agent.

Claim 30

A parenteral delivery system for administering a beneficial agent to a recipient, wherein the parenteral system comprises: I. a primary path, said primary path comprising: (a) a reservoir of a medical fluid; (b) a drip chamber in fluid communication with the reservoir; and, II. a by-pass that circumvents the primary path and comprises means for releasably connecting thereto said by-pass comprising: (c) an electrotransport apparatus for admitting a beneficial agent into the medical fluid, the electrotransport apparatus comprising: (1) a housing comprising a wall that surrounds an internal space; (2) an inlet in the wall adapted for receiving fluid from the primary path; (3) an outlet in the wall adapted for returning fluid to the primary path; (4) a pair of electrodes in spaced-apart position within the lumen; (5) an ion exchange membrane interposed between the electrodes; and, (6) a beneficial agent in the lumen between the wall and the ion exchange membrane.

Claim 31

A parenteral delivery system for administering a beneficial agent to a recipient, wherein the parenteral system comprises: I. a primary path, said primary path comprising: (a) a reservoir of a medical fluid; (b) a drip chamber in fluid communication with the reservoir; and, II. a by-pass that circumvents the primary path and comprises means for releasably connecting thereto said by-pass comprising: (c) an electrotransport apparatus for admitting a beneficial agent into the medical fluid, the electrotransport apparatus comprising: (1) a housing comprising a wall that surrounds an internal space; (2) an inlet in the wall adapted for receiving fluid from the primary path; (3) an outlet in the wall adapted for returning fluid to the primary path; (4) a pair of electrodes in spaced-apart position within the lumen; (5) an ion exchange membrane interposed between the electrodes; and, (6) a beneficial agent in the lumen between the wall and the ion exchange membrane.

Claim 32

The parenteral delivery system for administering the beneficial agent according to claim 26, wherein the electrodes are connected to an electrical power source.

Claim 33

The parenteral delivery system for administering the beneficial agent according to claim 26, wherein a fluid passageway is in the lumen extending from the inlet to the outlet.

Claim 34

The parenteral delivery system for administering the beneficial agent according to claim 28, wherein one of the electrodes is in the passageway.

Claim 35

The parenteral delivery system for administering the beneficial agent according to claim 28, wherein an additional ion exchange membrane is present in the lumen, and passageway is between the ion exchange membranes.