Patent US4539429A successfully refreshed from Google Patents.
US4539429A
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Substituted aminophenylalkyl ketones, their preparation and use
Assignee: STWB Inc
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Filing: 1983-07-11
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Granted: 1985-09-03
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Expires: 2003-07-11
Abstract
Abstract Novel lower-alkyl 2-(hydroxyphenylamino)phenyl ketones, useful as inhibitors of lipoxygenase activity, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl. The compounds are prepared by de-etherification of the corresponding alkyl or benzyl ethers which are in turn prepared by reacting a 2-(alkoxy- or benzyloxyphenylamino)benzoic acid with an alkyllithium.
Inventors
- 👤 Denis M. Bailey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 10:12
CPC Classifications
C; C07; C07C; C07C225/00; C07C225/22
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
29 words
A compound of the formula ##STR5## wherein: R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl.
Claim 2
Dependent Claim
29 words
A compound of the formula ##STR5## wherein: R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl.
Claim 3
Dependent Claim
14 words
A compound according to claim 1 wherein R' is hydrogen and Alk is methyl.
Claim 4
Dependent Claim
5 words
1-[2-(4-Hydroxyphenylamino)phenyl]ethanone, according to claim 2.
Claim 5
Dependent Claim
5 words
1-[2-(4-Hydroxyphenylamino)-5-methoxyphenyl]ethanone, according to claim 2.
Claim 6
Dependent Claim
24 words
A composition for inhibiting lipoxygenase activity which comprises a compound according to claim 1 together with one or more pharamceutically acceptable excipients or diluents.
Claim 7
Dependent Claim
26 words
A method for inhibiting lipoxygenase activity in a mammal which comprises administering to said mammal a pharmacologically effective amount of a composition according to claim 5.
Claim 8
Dependent Claim
28 words
A method of treating or preventing allergic asthma in a mammal which comprises administering to said mammal an anti-asthmatically effective amount of a composition according to claim 5.
References Cited (Backward Citations)
US2075359A
Cited
US3432507A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-02 | 1989-03-04 | 1989-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-02 | 1993-03-04 | 1993-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-02 | 1997-03-04 | 1997-09-03 | $7700.00 | Window Closed / Lapsed |