US4539399A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bonded phase material for chromatographic separations
Assignee: Advanced Separation Technologies Inc
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Filing: 1984-07-27
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Granted: 1985-09-03
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Expires: 2004-07-27
Abstract
Abstract A highly selective bonded phase material useful to separate a wide variety of organic and inorganic substances by thin layer chromatography (TLC), liquid chromatography (LC) or high performance liquid chromatography (HPLC) is produced by bonding a cyclodextrin to a silica gel by means of a specific silane linkage. The preparation of such materials and their uses are described.
Inventors
- 👤 Daniel W. Armstrong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:45
CPC Classifications
B; B01; B01D; B01D15/00; B01D15/08; B01D15/26; B01D15/38; B01D15/3833; B01J; B01J20/00; B01J20/02; B01J20/10; B01J20/103; B01J20/28; B01J20/28014; B01J20/28016; B01J20/281; B01J20/286; B01J20/29; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3225; B01J20/3227; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3263; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; B01J2220/00; B01J2220/50; B01J2220/54; B01J2220/58
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
84 words
The process of producing an improved chromatographic separation material which comprises: (a) providing a silica gel in particle form; (b) reacting said silica gel with a silane having between two and twenty carbon atoms in the chain length thereof to produce a product with an active terminal group; (c) further reacting the active terminal group of said product with an active primary or secondary hydroxyl group or groups of a cyclodextrin, whereby said cyclodextrin is chemically bonded to said silica gel by said silane.
Claim 2
Dependent Claim
84 words
The process of producing an improved chromatographic separation material which comprises: (a) providing a silica gel in particle form; (b) reacting said silica gel with a silane having between two and twenty carbon atoms in the chain length thereof to produce a product with an active terminal group; (c) further reacting the active terminal group of said product with an active primary or secondary hydroxyl group or groups of a cyclodextrin, whereby said cyclodextrin is chemically bonded to said silica gel by said silane.
Claim 3
Dependent Claim
18 words
The process of claim 1 wherein the silane has a chain length between six and nine carbon atoms.
Claim 4
Dependent Claim
17 words
The process of claim 1 wherein the active terminal group on the silane is an epoxy group.
Claim 5
Dependent Claim
16 words
The process of claim 1 wherein step (c) is effected in an inert anhydrous organic solvent.
Claim 6
Dependent Claim
16 words
The process of claim 1 wherein step (b) is carried out in an anhydrous organic solvent.
Claim 7
Dependent Claim
14 words
The process of claim 1 wherein the active terminal group is an alkyl halide.
Claim 8
Dependent Claim
14 words
The process of claim 6 wherein the halide is a bromide, chloride or iodide.
Claim 9
Dependent Claim
13 words
The process of claim 1 wherein the active terminal group is an alkene.
Claim 10
Dependent Claim
11 words
The process of claim 1 wherein the silane is 3-glycidoxypropyltrimethoxy silane.
Claim 11
Dependent Claim
14 words
The process of claim 1 wherein the cyclodextrin is an Alpha-, Beta- or Gamma-cyclodextrin.
Claim 12
Dependent Claim
12 words
The product of the process of any of claims 1 through 10.
Claim 13
Dependent Claim
48 words
A process for separating mixtures of organic compounds by HPLC, LC or TLC which comprises: (a) producing an improved chromatographic separation material by the process of any of claims 1 through 10; (b) conducting said mixture of organic compounds to said material; and (c) effecting the said separation.
Claim 14
Dependent Claim
30 words
The process of claim 12 wherein the mixture contains organic compounds which are isomers. cm 14. The process of claim 12 wherein the mixture contains organic compounds which are enantiomers.
Claim 15
Dependent Claim
14 words
The process of claim 12 wherein the mixture contains organic compounds which are enantiomers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-02 | 1989-03-04 | 1989-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-02 | 1993-03-04 | 1993-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-02 | 1997-03-04 | 1997-09-03 | $7700.00 | Window Closed / Lapsed |