US4539323A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-[1-(4-Amino-6,7-dialkoxy-2-quinazolinyl)-4-piperidyl]-oxazolidine-2,4-diones
Assignee: Boehringer Ingelheim GmbH
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Filing: 1983-09-14
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Granted: 1985-09-03
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Expires: 2003-09-14
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 and R2, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 8 carbon atoms or arylmethyl; or R1 and R2, together with each other, are -(CH2)4 or -(CH2)5-; and R3 and R4, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or arylmethyl; or R3 and R4, together with each other, are -CH3- or -CH2-CH2-; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of cardiovascular diseases, especially hypertension.
Inventors
- 👤 Anton Mentrup
- 👤 Ernst-Otto Renth
- 👤 Kurt Schromm
- 👤 Wolfgang Hoefke
- 👤 Wolfram Gaida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:07
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/02; C07D263/04; C07D413/00; C07D413/02; C07D413/04; A; A61; A61P; A61P25/00; A61P25/02; A61P9/00; A61P9/08; A61P9/12; C07D413/14
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
103 words
A compound of the formula ##STR15## wherein R 1 and R 2 are each independently hydrogen, straight or branched alkyl of 1 to 8 carbon atoms or benzyl; or R 1 and R 2 , together with each other, are --(CH 2 ) 4 -- or --(CH 2 ) 5 --; and R 3 and R 4 are each independently hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or benzyl; or R 3 and R 4 , together with each other, are --CH 3 -- or --CH 2 --CH 2 ; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
103 words
A compound of the formula ##STR15## wherein R 1 and R 2 are each independently hydrogen, straight or branched alkyl of 1 to 8 carbon atoms or benzyl; or R 1 and R 2 , together with each other, are --(CH 2 ) 4 -- or --(CH 2 ) 5 --; and R 3 and R 4 are each independently hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or benzyl; or R 3 and R 4 , together with each other, are --CH 3 -- or --CH 2 --CH 2 ; or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
40 words
A compound of claim 1, where R 1 and R 2 are each independently hydrogen or alkyl of 1 to 4 carbon atoms, and R 3 and R 4 are methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
17 words
A compound of claim 1, which is N-[1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidyl]-5-isopropyloxazolidine-2,4-dione or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
22 words
An hypotensive pharmaceutical composition consisting essentially of an inert pharmaceutical carrier and an effective hypotensive amount of a compound of claim 1.
Claim 6
Dependent Claim
33 words
The method of lowering the blood pressure of a warm-blooded animal in need thereof, which comprises perorally or parenterally administering to said animal an effective hypotensive amount of a compound of claim 1.
References Cited (Backward Citations)
US4309541A
Cited
FR2483920A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-02 | 1989-03-04 | 1989-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-02 | 1993-03-04 | 1993-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-02 | 1997-03-04 | 1997-09-03 | $7700.00 | Window Closed / Lapsed |