US4309541A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperidinyl-lactams
Assignee: Novartis Corp
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Filing: 1980-04-09
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Granted: 1982-01-05
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Expires: 2000-04-09
Abstract
Abstract N-[1-(4-amino-2-quinazolinyl)-3 or 4-piperidinyl]-lactams, e.g., those of the formula <IMAGE> R, R' = methoxy or together methylenedioxy; X = H2 or O; p = 2-8; q 0-8 2p-q = positive and salts thereof are antihypertensive agents.
Inventors
- 👤 Lincoln H. Werner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:51
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07D211/88
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
72 words
A 3- or 4-piperidinyl-lactam of the formula ##STR6## wherein M is hydrogen or an alkali metal; each of m and n is an integer from 1 to 3, but m+n=4; X represents oxo; and A is lower alkylene, 4 to 7 ring-membered cycloalkylene, cycloalkyl-lower alkylene, spirocycloalkane-lower alkylene, phenyl-lower alkylene unsubstituted or substituted in the benzene ring by up to 3 lower alkyl or lower alkoxy groups, or by one lower alkylenedioxy group.
Claim 2
Dependent Claim
72 words
A 3- or 4-piperidinyl-lactam of the formula ##STR6## wherein M is hydrogen or an alkali metal; each of m and n is an integer from 1 to 3, but m+n=4; X represents oxo; and A is lower alkylene, 4 to 7 ring-membered cycloalkylene, cycloalkyl-lower alkylene, spirocycloalkane-lower alkylene, phenyl-lower alkylene unsubstituted or substituted in the benzene ring by up to 3 lower alkyl or lower alkoxy groups, or by one lower alkylenedioxy group.
Claim 3
Dependent Claim
79 words
A compound as claimed in claim 1, wherein M is hydrogen or an alkali metal, each of m and n is an integer from 1 to 3, but m+n=4; X represents oxo; and A is lower alkylene, 4 to 7 ring-membered cycloalkylene, cycloalkyl-lower alkylene, spirocycloalkane-lower alkylene, phenyl-lower alkylene unsubstituted or substituted in the benzen ring by up to 3 alkyl or alkoxy groups with up to 4 carbon atoms, or one alkylenedioxy group with up to 2 carbon atoms.
Claim 4
Dependent Claim
53 words
A compound as claimed in claim 1, wherein M is hydrogen or an alkali metal; each of C m H 2m and C n H 2n is ethylene; X represents oxo; and A is lower alkylene, 5 or 6 ring-membered 1,2-cycloalkylene or (cycloalkyl, spirocycloalkane or phenyl)-alkylene with up to 8 carbon atoms each.
Claim 5
Dependent Claim
53 words
A compound as claimed in claim 1 and having the formula ##STR7## wherein M is hydrogen or an alkali metal; X represents oxo; C p H 2p-q is alkylene, phenylalkylene or spirocycloalkane-alkylene wherein p is an integer from 2 to 8, q is the integer 0, 2 or 8, and 2p-q is positive.
Claim 6
Dependent Claim
28 words
A compound as claimed in claim 4, wherein M is hydrogen or an alkali metal; X is oxo; and C p H 2p-q is ethylene, phenylethylene or 1,3-propylene.
Claim 7
Dependent Claim
11 words
A compound as claimed in claim 4 and being the 1-(4-piperidinyl)-pyrrolidin-2,5-dione.
Claim 8
Dependent Claim
11 words
A compound as claimed in claim 4, and being the 1-(4-piperidinyl)-piperidin-2,6-dione.
Claim 9
Dependent Claim
11 words
A compound as claimed in claim 4, and being the 1-(4-piperidinyl)-3-phenylpyrrolidin-2,5-dione.
Claim 10
Dependent Claim
11 words
A compound as claimed in claim 4, and being the 1-(4-piperidinyl)-3-methylpyrrolidin-2,5-dione.
Claim 11
Dependent Claim
11 words
A compound as claimed in claim 4, and being the 8-(4-piperidinyl)-8-azaspiro[4,5]decan-7,9-dione.
References Cited (Backward Citations)
GB686354A
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US3398151A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-01-04 | 1985-07-06 | 1986-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-01-04 | 1989-07-06 | 1990-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-01-04 | 1993-07-06 | 1994-01-05 | $7700.00 | Window Closed / Lapsed |