Patent US4535485A successfully refreshed from Google Patents.
US4535485A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric acrylic prothesis
Assignee: United States Surgical Corp
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Filing: 1982-03-12
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Granted: 1985-08-20
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Expires: 2002-03-12
Abstract
Abstract This invention relates to implantable porous prostheses for use as bone or hard tissue replacements anywhere in the body. The porous implants comprise loose, individual polymeric particles of a specified size, coated with a hydrophilic material and barium sulfate particles. The prostheses are biologically compatible in the body and promote bone and tissue ingrowth and attachment. This invention also relates to a method for producing the novel prosthetic devices disclosed herein.
Inventors
- 👤 Arthur Ashman
- 👤 Paul F. Bruins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:20
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/48; A61L27/50; A61B; A61B90/00; A61B90/39
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
156 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 2
Dependent Claim
156 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 3
Dependent Claim
26 words
The packing material of claim 1 in which the diameter of the particles is in the range of from about 590 microns to about 840 microns.
Claim 4
Dependent Claim
20 words
The packing material of claim 2 in which the cores of the particles are composed of an acrylic polymeric material.
Claim 5
Dependent Claim
16 words
The packing material of claim 3 in which the cores of the particles are polymethylmethacrylate beads.
Claim 6
Dependent Claim
14 words
The packing material of claim 4 in which the polymethylmethacrylate beads include a plasticizer.
Claim 7
Dependent Claim
23 words
The packing material of claim 3 in which the cores of the particles are composed of a copolymer of methylmethacrylate and a comonomer.
Claim 8
Dependent Claim
16 words
The packing material of claim 3 in which the hydrophilic polymeric material is a polymeric hydroxyethylmethacrylate.
Claim 9
Dependent Claim
180 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packaging material comprising disjoint particles, having a diameter in the range of from about 590 microns to about 840 microns, each particle having an inner core comprised of a biologically-compatible acrylic polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a biologically-compatible hydrophilic polymeric hydroxyethylmethacrylate material, the ratio of the weight of the polymeric hydroxyethylmethacrylate to the weight of the cores of the particles is in the range of from about 0.04 to about 0.07, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having a least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 10
Dependent Claim
180 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packaging material comprising disjoint particles, having a diameter in the range of from about 590 microns to about 840 microns, each particle having an inner core comprised of a biologically-compatible acrylic polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a biologically-compatible hydrophilic polymeric hydroxyethylmethacrylate material, the ratio of the weight of the polymeric hydroxyethylmethacrylate to the weight of the cores of the particles is in the range of from about 0.04 to about 0.07, each particle incorporating a sufficient quantity of barium sulfate to render a prosthetic implant formed of a compacted mass of the particles visible in an X-ray radiograph, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having a least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 11
Dependent Claim
21 words
The packing material of claim 8 in which the polymeric hydroxyethylmethacrylate comprises a copolymer of monomeric hydroxyethylmethacrylate and a cross-linking agent.
Claim 12
Dependent Claim
14 words
The packing material of claim 9 in which the cross-linking agent is triethyleneglycol dimethacrylate.
Claim 13
Dependent Claim
35 words
The packing material of claim 10 in which the ratio of the weight of the triethyleneglycol dimethacrylate to the weight of the monomeric hydroxyethylmethacrylate is in the range of from about 0.01 to about 0.05.
Claim 14
Dependent Claim
20 words
The packing material of claim 8 in which the barium sulfate is located in the coating of hydrophilic polymeric material.
Claim 15
Dependent Claim
37 words
The packing material of claim 12 in which the ratio of the weight of the barium sulfate to the weight of the cores of the particles is in the range of from about 0.25 to about 0.43.
Claim 16
Dependent Claim
26 words
The packing material of claim 13 in which the barium sulfate is in the form of particles having a diameter of less than about one micron.
Claim 17
Dependent Claim
135 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a radio-opaque material, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 18
Dependent Claim
135 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a radio-opaque material, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 19
Dependent Claim
26 words
The packing material of claim 15 in which the diameter of the particles is in the range of from about 590 microns to about 840 microns.
Claim 20
Dependent Claim
20 words
The packing material of claim 16 in which the cores of the particles are composed of an acrylic polymeric material.
Claim 21
Dependent Claim
16 words
The packing material of claim 17 in which the cores of the particles are polymethylmethacrylate beads.
Claim 22
Dependent Claim
14 words
The packing material of claim 18 in which the polymethylmethacrylate beads include a plasticizer.
Claim 23
Dependent Claim
23 words
The packing material of claim 17 in which the cores of the particles are composed of a copolymer of methylmethacrylate and a comonomer.
Claim 24
Dependent Claim
16 words
The packing material of claim 17 in which the hydrophilic polymeric material is a polymeric hydroxyethylmethacrylate.
Claim 25
Dependent Claim
37 words
The packing material of claim 21 in which the ratio of the weight of the polymeric hydroxyethylmethacrylate to the weight of the cores of the particles is in the range of from about 0.04 to about 0.07.
Claim 26
Dependent Claim
21 words
The packing material of claim 22 in which the polymeric hydroxyethylmethacrylate comprises a copolymer of monomeric hydroxyethylmethacrylate and a cross-linking agent.
Claim 27
Dependent Claim
14 words
The packing material of claim 23 in which the cross-linking agent is triethyleneglycol dimethacrylate.
Claim 28
Dependent Claim
35 words
The packing material of claim 24 in which the ratio of the weight of the triethyleneglycol dimethacrylate to the weight of the monomeric hydroxyethylmethacrylate is in the range of from about 0.01 to about 0.05.
Claim 29
Dependent Claim
14 words
The packing material of claim 21 in which the radio-opaque material is barium sulfate.
Claim 30
Dependent Claim
20 words
The packing material of claim 26 in which the barium sulfate is located in the coating of hydrophilic polymeric material.
Claim 31
Dependent Claim
37 words
The packing material of claim 27 in which the ratio of the weight of the barium sulfate to the weight of the cores of the particles is in the range of from about 0.25 to about 0.43.
Claim 32
Dependent Claim
26 words
The packing material of claim 28 in which the barium sulfate is in the form of particles having a diameter of less than about one micron.
Claim 33
Dependent Claim
144 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to prevent bonding between the particles, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
Claim 34
Dependent Claim
144 words
A packing material for forming in vivo prosthetic implants for hard tissue, the packing material comprising disjoint micron sized particles, each particle having an inner core comprised of a first biologically-compatible polymeric material and having an outer coating generally surrounding the inner core, the outer coating being comprised of a second biologically-compatible polymeric material, the second polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material, each particle incorporating a sufficient quantity of barium sulfate to prevent bonding between the particles, the particles being of a size to permit a mass of the disjoint particles to be packed in a body cavity having at least one surface comprised of a hard tissue to form a prosthetic implant for the hard tissue with interstices between compacted particles of the prosthetic implant forming pores into which tissue can grow.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-19 | 1989-02-18 | 1989-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-19 | 1993-02-18 | 1993-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-19 | 1997-02-18 | 1997-08-20 | $7700.00 | Window Closed / Lapsed |