Patent US4533562A successfully refreshed from Google Patents.
US4533562A
Expired / Lapsed
US
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Method of preparing coated solid preparations
Assignee: Sankyo Co Ltd
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Filing: 1984-04-19
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Granted: 1985-08-06
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Expires: 2004-04-19
Abstract
Abstract Solid materials, especially pharmaceutical preparations, are coated, without the use of solvents, with a powdered film-forming polymer and with a liquid plasticizer having an affinity for the polymer.
Inventors
- 👤 Yoshihiko Ikegami
- 👤 Kozo Kurihara
- 👤 Izuo Ichikawa
- 👤 Hisanori Nakane
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/284; A61K9/286; A61K9/2866; A61K9/2886; A61K9/282
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
55 words
A method of coating a solid pharmaceutical preparation consisting essentially of first coating said solid pharmaceutical preparation with a liquid plasticizer and then coating with a powdered film-forming polymer, said liquid plasticizer swelling or dissolving said polymer whereby said powdered polymer particles are plasticized and form a substantially uniform coating on said solid pharmaceutical preparation.
Claim 2
Independent Claim
55 words
A method of coating a solid pharmaceutical preparation consisting essentially of first coating said solid pharmaceutical preparation with a liquid plasticizer and then coating with a powdered film-forming polymer, said liquid plasticizer swelling or dissolving said polymer whereby said powdered polymer particles are plasticized and form a substantially uniform coating on said solid pharmaceutical preparation.
Claim 3
Dependent Claim
96 words
A method as claimed in claim 1, wherein said polymer is selected from the group consisting of hydroxypropyl methylcellulose phthalate, cellulose acetate phthalate, methyl methacrylate/methacrylic acid copolymer, polyvinyl acetate phthalate, carboxymethyl ethylcellulose, polyvinyl alcohol phthalate, starch acetate phthalate, cellulose acetate succinate, styrene/maleic acid copolymer, polyvinyl acetal diethylaminoacetate, poly(dimethylaminoethyl methacrylate), benzylaminomethylcellulose, diethylaminomethylcellulose, benzylaminoethyl hydroxyethylcellulose, cellulose acetate diethylaminoacetate, cellulose acetate dibutylaminohydroxypropyl ether, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, polyvinyl alcohol, gelatin, polyvinylpyrrolidone, pyrrolidone/vinyl acetate copolymer, polyethylene glycol, hydroxypropyl methylcellulose, hydroxypropylcellulose, vinylpyrrolidone/vinyl acetate copolymer, ethylcellulose, methylvinylpyridine/methyl acrylate methacrylate copolymer, acetylcellulose, nitrocellulose, polyvinyl acetate, shellac and mixtures of two or more thereof.
Claim 4
Dependent Claim
19 words
A method as claimed in claim 1, wherein the powdered polymer has a particle size less than 100 μm.
Claim 5
Dependent Claim
19 words
A method as claimed in claim 1, wherein the powdered polymer has a particle size less than 30 μm.
Claim 6
Dependent Claim
19 words
A method as claimed in claim 1, wherein the powdered polymer has a particle size less than 10 μm.
Claim 7
Dependent Claim
43 words
A method as claimed in claim 1, wherein the plasticizer is selected from the group consisting of triacetin, glycerol monocaprylate, monoalkyl esters of diacetin, dibuty phthalate, glycerol, diacetone alcohol, propylene glycol, polyethylene glycol 400, polyethylene glycol 4000, polyoxyethylene sorbitan monooleate and sorbitan trioleate.
Claim 8
Dependent Claim
36 words
A method as claimed in claim 1, wherein the plasticizer is solid at ambient temperature and is melted prior to or after its application to said solid material but prior to coating with said powdered polymer.
Claim 9
Dependent Claim
20 words
A method as claimed in claim 1, wherein said preparation is selected from granules, fine powders, pills, capsules and tablets.
Claim 10
Dependent Claim
96 words
A method as claimed in claim 3, wherein said polymer is selected from the group consisting of hydroxypropyl methylcellulose phthalate, cellulose acetate phthalate, methyl methacrylate/methacrylic acid copolymer, polyvinyl acetate phthalate, carboxymethyl ethylcellulose, polyvinyl alcohol phthalate, starch acetate phthalate, cellulose acetate succinate, styrene/maleic acid copolymer, polyvinyl acetal diethylaminoacetate, poly(dimethylaminoethyl methacrylate), benzylaminomethylcellulose, diethylaminomethylcellulose, benzylaminoethyl hydroxyethylcellulose, cellulose acetate diethylaminoacetate, cellulose acetate dibutylaminohydroxypropyl ether, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, polyvinyl alcohol, gelatin, polyvinylpyrrolidone, pyrrolidone/vinyl acetate copolymer, polyethylene glycol, hydroxypropyl methylcellulose, hydroxypropylcellulose, vinylpyrrolidone/vinyl acetate copolymer, ethylcellulose, methylvinylpyridine/methyl acrylate methacrylate copolymer, acetylcellulose, nitrocellulose, polyvinyl acetate, shellac and mixtures of two or more thereof.
Claim 11
Dependent Claim
36 words
A method as claimed in claim 9, wherein said polymer is selected from the group consisting of hydroxypropyl methylcellulose phthalate, carboxymethyl ethylcellulose, polyvinyl acetal diethylaminoacetate, vinylpyrrolidone/vinyl acetate copolymer, ethylcellulose and mixtures of two or more thereof.
Claim 12
Dependent Claim
36 words
A method as claimed in claim 3, wherein said polymer is selected from the group consisting of hydroxypropyl methylcellulose phthalate, carboxymethyl ethylcellulose, polyvinyl acetal diethylaminoacetate, vinylpyrrolidone/vinyl acetate copolymer, ethylcellulose and mixtures of two or more thereof.
Claim 13
Dependent Claim
43 words
A method as claimed in claim 3, wherein said plasticizer is selected from the group consisting of triacetin, glycerol monocaprylate, monoalkyl esters of diacetin, dibutyl phthalate, glycerol, diacetone alcohol, propylene glycol, polyethylene glycol 400, polyethylene glycol 4000, polyoxyethylene sorbitan monooleate and sorbitan trioleate.
Claim 14
Dependent Claim
42 words
A method as claimed in claim 3, wherein said plasticizer is selected from the group consisting of triacetin, glycerol monocaprylate, propylene glycol, polyethylene glycol 4000, polyoxyethylene sorbitan monooleate, monoalkyl esters of diacetin, polyethylene glycol 400 and mixtures of two or more therof.
Claim 15
Dependent Claim
19 words
A method as claimed in claim 3, wherein said powdered polymer has a particle size less than 30 μm.
Claim 16
Dependent Claim
19 words
A method as claimed in claim 14, wherein said powdered polymer has a particle size less than 10 μm.
Claim 17
Independent Claim
108 words
A method of coating a solid pharmaceutical preparation consisting essentially of first coating said preparation with a liquid plasticizer selected from the group consisting of triacetin, glycerol monocaprylate, propylene glycol, polyethylene glycol 4000, polyoxyethylene sorbitan monooleate, monoalkyl esters of diacetin, polyethylene glycol 400 and mixtures of two or more thereof, and then with a powdered film-forming polymer having a particle diameter less than about 30μ and selected from the group consisting of hydroxypropyl methylcellulose phthalate, carboxymethyl ethylcellulose, polyvinyl acetal diethylaminoacetate, vinylpyrrolidone/vinyl acetate copolymer, ethylcellulose and mixtures of two or more thereof whereby said powdered polymer particles are plasticized and form a substantially uniform coating on said solid material.
Claim 18
Independent Claim
108 words
A method of coating a solid pharmaceutical preparation consisting essentially of first coating said preparation with a liquid plasticizer selected from the group consisting of triacetin, glycerol monocaprylate, propylene glycol, polyethylene glycol 4000, polyoxyethylene sorbitan monooleate, monoalkyl esters of diacetin, polyethylene glycol 400 and mixtures of two or more thereof, and then with a powdered film-forming polymer having a particle diameter less than about 30μ and selected from the group consisting of hydroxypropyl methylcellulose phthalate, carboxymethyl ethylcellulose, polyvinyl acetal diethylaminoacetate, vinylpyrrolidone/vinyl acetate copolymer, ethylcellulose and mixtures of two or more thereof whereby said powdered polymer particles are plasticized and form a substantially uniform coating on said solid material.
Claim 19
Dependent Claim
19 words
A method as claimed in claim 16, wherein said polymer has a particle size less than about 10 μm.
Claim 20
Dependent Claim
25 words
A method as claimed in claim 16, wherein said pharmaceutical preparation is selected from the group consisting of granules, fine powders, pills, capsules and tablets.
Claim 21
Dependent Claim
24 words
A method as claimed in claim 1 wherein said plasticizer is in an amount less than one-half of the weight of said powdered polymer.
Claim 22
Dependent Claim
24 words
A method as claimed in claim 9 wherein said plasticizer is in an amount less than one-half of the weight of said powdered polymer.
Claim 23
Dependent Claim
24 words
A method as claimed in claim 16 wherein said plasticizer is in an amount less than one-half of the weight of said powdered polymer.
Claim 24
Dependent Claim
24 words
A method as claimed in claim 18 wherein said plasticizer is in an amount less than one-half of the weight of said powdered polymer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-05 | 1989-02-04 | 1989-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-05 | 1993-02-04 | 1993-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-05 | 1997-02-04 | 1997-08-06 | $7700.00 | Window Closed / Lapsed |