US4532344A
Expired / Lapsed
US
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Fluoranthene derivatives
Assignee: SmithKline Beecham Corp
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Filing: 1983-05-23
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Granted: 1985-07-30
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Expires: 2003-05-23
Abstract
Abstract The present invention relates to compounds of formula (I) <IMAGE> (I) wherein Ar is a fluoranthene or substituted fluoranthene ring system; R1 is a C1-3 alkylene moiety; R2 is hydrogen or a C1-6 alkyl group; R3 is a hydroxy C1-6 alkyl group; R4 and R5 are the same or different and are hydrogen, C1-6 alkyl or hydroxy C1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R3, R4, and R5; Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.
Inventors
- 👤 Kenneth W. Bair
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:03
CPC Classifications
C; C07; C07C; C07C215/00; C07C215/02; C07C215/22; C07C215/28; C07C215/38; A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/22; C07C2603/24; C07C2603/26; C07C2603/40; C07C2603/42; C07C2603/48; C07C2603/50
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
104 words
A compound of formula (I) ##STR8## wherein Ar is a fluoranthene ring system or a fluoranthene ring system substituted with halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, hydroxy, halo C 1-6 alkyl, hydroxy C 1-6 alkylthio, cyano, C 1-6 alkylsulphinyl or C 1-6 alkylsulphenyl; R 1 is a C 1-3 alkylene, p1 R 2 is hydrogen or a C 1-6 alkyl, R 3 is hydroxy C 1-6 alkyl, R 4 and R 5 are the same or different and are hydrogen, C 1-6 alkyl or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
104 words
A compound of formula (I) ##STR8## wherein Ar is a fluoranthene ring system or a fluoranthene ring system substituted with halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio, hydroxy, halo C 1-6 alkyl, hydroxy C 1-6 alkylthio, cyano, C 1-6 alkylsulphinyl or C 1-6 alkylsulphenyl; R 1 is a C 1-3 alkylene, p1 R 2 is hydrogen or a C 1-6 alkyl, R 3 is hydroxy C 1-6 alkyl, R 4 and R 5 are the same or different and are hydrogen, C 1-6 alkyl or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
18 words
2-((3-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
18 words
2-((3-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
10 words
The hydrochloric acid salt of the compound of claim 2.
Claim 6
Dependent Claim
18 words
2-((7-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
18 words
2-((7-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
10 words
The hydrochloric acid salt of the compound of claim 4.
Claim 9
Dependent Claim
18 words
2-((8-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol, or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
18 words
2-((8-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol, or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
10 words
The hydrochloric acid salt of the compound of claim 6.
Claim 12
Dependent Claim
18 words
2-hydroxymethyl-2-((3-fluoranthenylmethyl)amino)-1,3-propanediol, or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 13
Dependent Claim
18 words
2-hydroxymethyl-2-((3-fluoranthenylmethyl)amino)-1,3-propanediol, or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 14
Dependent Claim
18 words
2-ethyl-2-((3-fluoranthenylmethyl)amino)-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 15
Dependent Claim
18 words
2-ethyl-2-((3-fluoranthenylmethyl)amino)-1,3-propanediol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 16
Dependent Claim
10 words
The hydrochloric acid salt of the compound of claim 9.
Claim 17
Dependent Claim
18 words
2-((3-fluoranthenylmethyl)amino)-2-methyl-propanol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 18
Dependent Claim
18 words
2-((3-fluoranthenylmethyl)amino)-2-methyl-propanol or a C 1-6 alkylcarboxylic acid ester derived therefrom or a pharmaceutically acceptable acid addition salt thereof.
Claim 19
Dependent Claim
10 words
The hydrochloric acid salt of the compound of claim 11.
Claim 20
Dependent Claim
10 words
The hydrochloric acid salt of a compound of claim 1.
Claim 21
Dependent Claim
10 words
The citric acid salt of a compound of claim 1.
Claim 22
Dependent Claim
10 words
The acetic acid salt of a compound of claim 1.
Claim 23
Dependent Claim
10 words
The benzenesulfonic acid salt of a compound of claim 1.
Claim 24
Dependent Claim
10 words
The lactic acid salt of a compound of claim 1.
Claim 25
Dependent Claim
10 words
The methanesulfonic acid salt of a compound of claim 1.
Claim 26
Dependent Claim
7 words
2-((3-fluoranthenylmethyl)amino)2-methyl-1,3-propanediol or a pharmaceutically acceptable salt thereof.
Claim 27
Dependent Claim
7 words
2-((3-fluoranthenylmethyl)amino)2-methyl-1,3-propanediol or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US4197249A
Cited
US4258181A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-29 | 1989-01-28 | 1989-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-29 | 1993-01-28 | 1993-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-29 | 1997-01-28 | 1997-07-30 | $7700.00 | Window Closed / Lapsed |