Patent US4530790A successfully refreshed from Google Patents.
US4530790A
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US
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Cholecystokinin antagonists
Assignee: Merck and Co Inc
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Filing: 1983-07-01
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Granted: 1985-07-23
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Expires: 2003-07-01
Abstract
Abstract The compound having Formula I and several minor related compounds are produced by the aerobic fermentation of Aspergillus alliaceus Thom and Church, ATCC No. 20655 or ATCC No. 20656. <IMAGE> I The compound of Formula I and the several minor related compounds are antagonists of cholecystokinin (CCK). CCK antagonists are useful in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems of animals, especially humans.
Inventors
- 👤 Richard L. Monaghan
- 👤 Michael A. Goetz
- 👤 Raymond S. L. Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 19:14
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C12; C12N; C12N1/00; C12N1/14; C12N1/145; C12P; C12P17/00; C12P17/18; C12P17/182; C12R; C12R2001/00; C12R2001/645; C12R2001/66; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911; Y10S435/913
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
12 words
The compound having the Formula I: ##STR10## and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
12 words
The compound having the Formula I: ##STR10## and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
39 words
The mixture of the compound of claim 1 and its minor related components A, B, C and D, produced by the controlled aqueous aerobic fermentation of a strain of Aspergillus alliaceus Thom and Church in an assimilable nutrient medium.
Claim 4
Dependent Claim
18 words
The mixture of claim 2 wherein the strain of Aspergillus alliaceus Thom and Church is ATCC No. 20655.
Claim 5
Dependent Claim
18 words
The mixture of claim 2 wherein the strain of Aspergillus alliaceus Thom and Church is ATCC No. 20656.
Claim 6
Dependent Claim
24 words
The mixture of claim 2 wherein the aerobic fermentation is at a temperature range of from 20° to 37° for at least 24 hours.
Claim 7
Dependent Claim
38 words
The compound of Formula I of claim 1 having the NMR spectrum of FIG. 1, the IR spectrum of FIG. 2, the UV spectrum of FIG. 3 and the specific stereochemistry depicted in the following spatial formula: ##STR11##
Claim 8
Dependent Claim
15 words
The minor component A having the NMR spectrum of FIG. 4 and the structure: ##STR12##
Claim 9
Dependent Claim
15 words
The minor component A having the NMR spectrum of FIG. 4 and the structure: ##STR12##
Claim 10
Dependent Claim
15 words
The minor component B having the NMR spectrum of FIG. 5 and the structure: ##STR13##
Claim 11
Dependent Claim
15 words
The minor component B having the NMR spectrum of FIG. 5 and the structure: ##STR13##
Claim 12
Dependent Claim
15 words
The minor component C having the NMR spectrum of FIG. 6 and the structure: ##STR14##
Claim 13
Dependent Claim
15 words
The minor component C having the NMR spectrum of FIG. 6 and the structure: ##STR14##
Claim 14
Dependent Claim
15 words
The minor component D having the NMR spectrum of FIG. 7 and the structure: ##STR15##
Claim 15
Dependent Claim
15 words
The minor component D having the NMR spectrum of FIG. 7 and the structure: ##STR15##
References Cited (Backward Citations)
US4187306A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-22 | 1989-01-21 | 1989-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-22 | 1993-01-21 | 1993-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-22 | 1997-01-21 | 1997-07-23 | $7700.00 | Window Closed / Lapsed |