Patent US4528288A successfully refreshed from Google Patents.
US4528288A
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Substituted triazolo[1,5-c]pyrimidines
Assignee: Riker Laboratories Inc
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Filing: 1983-05-02
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Granted: 1985-07-09
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Expires: 2003-05-02
Abstract
Abstract Substituted triazolo[1,5-c]pyrimidines which are bronchodilators. The pharmacological use of these compounds and pharmaceutical compositions containing these compounds are also described.
Inventors
- 👤 James J. Wade
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 17:16
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/58
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
37 words
A compound of the formula: ##STR6## wherein R 2 is hydrogen or lower alkyl; R 5 is benzylthio; and R 7 and R 8 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 2
Dependent Claim
37 words
A compound of the formula: ##STR6## wherein R 2 is hydrogen or lower alkyl; R 5 is benzylthio; and R 7 and R 8 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 3
Dependent Claim
48 words
A compound of the formula: ##STR7## wherein R 2 is mercapto, lower alkoxy, lower alkylthio or hydroxy; R 5 is lower alkylthio; R 7 is hydrogen, lower alkyl, lower alkylthio or halogen; and R 8 is hydrogen, lower alkyl, or halogen; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 4
Dependent Claim
48 words
A compound of the formula: ##STR7## wherein R 2 is mercapto, lower alkoxy, lower alkylthio or hydroxy; R 5 is lower alkylthio; R 7 is hydrogen, lower alkyl, lower alkylthio or halogen; and R 8 is hydrogen, lower alkyl, or halogen; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 5
Dependent Claim
41 words
A compound of the formula: ##STR8## wherein R 2 is hydroxy; R 5 is lower alkylthio; R 7 is hydrogen, lower alkyl, lower alkylthio, or halogen; and R 8 is hydrogen or lower alkyl; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 6
Dependent Claim
41 words
A compound of the formula: ##STR8## wherein R 2 is hydroxy; R 5 is lower alkylthio; R 7 is hydrogen, lower alkyl, lower alkylthio, or halogen; and R 8 is hydrogen or lower alkyl; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 7
Dependent Claim
20 words
A bronchodilator pharmaceutical composition comprising an effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
20 words
A bronchodilator pharmaceutical composition comprising an effective amount of a compound according to claim 2 and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
20 words
A bronchodilator pharmaceutical composition comprising an effective amount of a compound according to claim 3 and a pharmaceutically acceptable carrier.
Claim 10
Independent Claim
144 words
A method for obtaining bronchodilation in a mammal, wherein an effective amount of a bronchodilator compound is administered to said mammal, said bronchodilator compound being of the formula ##STR9## wherein R 2 is hydrogen, lower alkyl, mercapto, lower alkylthio, lower alkoxy or hydroxy; R 5 is (lower alkyl)amino, di(lower alkyl)amino, alklthio or benzylthio; R 7 is hydrogen, lower alkyl, halogen or lower alkylthio; and R 8 is hydrogen, lower alkyl or halogen, and is hydrogen or lower alkyl when R 7 is halogen; with the provisos that at least one of R 5 and R 7 is lower alkylthio, (lower alkyl)amino, di(lower alkyl)amino, or benzylthio; and when one of R 5 and R 7 is lower alkylthio, at least another one of R 2 , R 5 and R 7 is mercapto, lower alkylthio or lower alkoxy; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 11
Independent Claim
144 words
A method for obtaining bronchodilation in a mammal, wherein an effective amount of a bronchodilator compound is administered to said mammal, said bronchodilator compound being of the formula ##STR9## wherein R 2 is hydrogen, lower alkyl, mercapto, lower alkylthio, lower alkoxy or hydroxy; R 5 is (lower alkyl)amino, di(lower alkyl)amino, alklthio or benzylthio; R 7 is hydrogen, lower alkyl, halogen or lower alkylthio; and R 8 is hydrogen, lower alkyl or halogen, and is hydrogen or lower alkyl when R 7 is halogen; with the provisos that at least one of R 5 and R 7 is lower alkylthio, (lower alkyl)amino, di(lower alkyl)amino, or benzylthio; and when one of R 5 and R 7 is lower alkylthio, at least another one of R 2 , R 5 and R 7 is mercapto, lower alkylthio or lower alkoxy; or a pharmaceutically acceptable acid-addition salt thereof.
Claim 12
Dependent Claim
12 words
A method according to claim 7, wherein said compound is administered orally.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-08 | 1989-01-07 | 1989-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-08 | 1993-01-07 | 1993-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-08 | 1997-01-07 | 1997-07-09 | $7700.00 | Window Closed / Lapsed |