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US4525347A
Expired / Lapsed
US
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Antiinflammatory analgesic gelled ointment
Assignee: Kowa Co Ltd
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Filing: 1983-02-22
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Granted: 1985-06-25
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Expires: 2003-02-22
Abstract
Abstract An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C1-C5 alcohol ester of a C4-C14 monocarboxylic acid and a C1-C3 alcohol diester of a C4-C10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.
Inventors
- 👤 Toshio Inagi
- 👤 Toyojiro Muramatsu
- 👤 Hidetaka Nagai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:32
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/30; A61K47/32; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
159 words
An anti-inflammatory analgesic gelled ointment, comprising: (a) indomethacin in the range of 0.5 to 1.5% by weight; (b) a medium ranging from 15 to 85% by weight and consisting essentially of a hydroxy compound selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, ethanol, and isopropanol, water in the range of 30 to 55% by weight, and a gelating agent ranging from 0.5 to 5% by weight of a carboxyvinyl polymer which has been neutralized with aqueous ammonia; (c) an adjuvant being present in the range of 0.5 to 5% by weight and selected from the group consisting of a C 1 -C 5 alcohol ester of a C 4 -C 14 monocarboxylic acid and a C 1 -C 3 alcohol diester of a C 4 -C 10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of said ointment, said ointment being adjusted in its pH of 4.8 to 7.5.
Claim 2
Dependent Claim
159 words
An anti-inflammatory analgesic gelled ointment, comprising: (a) indomethacin in the range of 0.5 to 1.5% by weight; (b) a medium ranging from 15 to 85% by weight and consisting essentially of a hydroxy compound selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, ethanol, and isopropanol, water in the range of 30 to 55% by weight, and a gelating agent ranging from 0.5 to 5% by weight of a carboxyvinyl polymer which has been neutralized with aqueous ammonia; (c) an adjuvant being present in the range of 0.5 to 5% by weight and selected from the group consisting of a C 1 -C 5 alcohol ester of a C 4 -C 14 monocarboxylic acid and a C 1 -C 3 alcohol diester of a C 4 -C 10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of said ointment, said ointment being adjusted in its pH of 4.8 to 7.5.
Claim 3
Dependent Claim
169 words
An anti-inflammatory analgesic gelled ointment, comprising: (a) indomethacin in the range of 0.5 to 1.5% by weight; (b) a medium ranging from 15 to 85% by weight and consisting essentially of a hydroxy compound selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, ethanol, and isopropanol, water in the range of 30 to 55% by weight, and a gelating agent ranging from 0.5 to 5% by weight and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia; (c) an adjuvant being present in the range of 0.5 to 5% by weight and selected from the group consisting of a C 1 -C 5 alcohol ester of a C 4 -C 14 monocarboxylic acid and a C 1 -C 3 alcohol diester of a C 4 -C 10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of said ointment, said ointment being adjusted in its pH of 4.8 to 7.5.
Claim 4
Dependent Claim
169 words
An anti-inflammatory analgesic gelled ointment, comprising: (a) indomethacin in the range of 0.5 to 1.5% by weight; (b) a medium ranging from 15 to 85% by weight and consisting essentially of a hydroxy compound selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, ethanol, and isopropanol, water in the range of 30 to 55% by weight, and a gelating agent ranging from 0.5 to 5% by weight and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia; (c) an adjuvant being present in the range of 0.5 to 5% by weight and selected from the group consisting of a C 1 -C 5 alcohol ester of a C 4 -C 14 monocarboxylic acid and a C 1 -C 3 alcohol diester of a C 4 -C 10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of said ointment, said ointment being adjusted in its pH of 4.8 to 7.5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-24 | 1988-12-24 | 1989-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-24 | 1992-12-24 | 1993-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-24 | 1996-12-24 | 1997-06-25 | $7700.00 | Window Closed / Lapsed |