Patent US4525340A successfully refreshed from Google Patents.
US4525340A
Expired / Lapsed
US
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Composite body for long-term delivery of effective substances
Assignee: Akzo NV
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Filing: 1983-04-20
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Granted: 1985-06-25
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Expires: 2003-04-20
Abstract
Abstract A composite body for long-term delivery of effective substances has a carrier for effective substances composed of a microporous polymer, and a coating composed of cellulose nitrate. The carrier can be composed of a thermoplastic polymer with a substantially isotropic microporous cellular polymer structure with a plurality of substantially spherical cells of a mean diameter between 0.5 and 100 micrometers. The cells are connected with one another by pores. The composite body serves for long-term delivery of peptides, hormones, neurotransmitters, particularly vasopressin and oxytocin.
Inventors
- 👤 Wolfgang Lange
- 👤 G. J. Boer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0092; A01; A01N; A01N25/00; A01N25/26; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
40 words
A composite body for long-term delivery of effective substances, comprising a carrier for effective substance and composed of a microporous thermoplastic polymer with pores containing effective substances; and a coating composed of cellulose nitrate in contact with said microporous polymer.
Claim 2
Dependent Claim
40 words
A composite body for long-term delivery of effective substances, comprising a carrier for effective substance and composed of a microporous thermoplastic polymer with pores containing effective substances; and a coating composed of cellulose nitrate in contact with said microporous polymer.
Claim 3
Dependent Claim
90 words
A composite body as defined in claim 1, wherein said microporous has a substantially isothropic microporous cellular polymer structure, said thermoplastic polymer having a plurality of substantially spherical cells with mean diameter of substantially between 0.5 and 100 μm and a plurality of pores which connect neighboring cells with one another, said pores having a diameter which is smaller than the diameter of said cells, and the ratio of an average diameter of said cells to an average diameter of said pores being equal to substantially between 2:1 and 200:1.
Claim 4
Dependent Claim
44 words
A composite body as defined in claim 2, wherein said spherical cells of said thermoplastic polymer have a mean diameter of substantially between 0.5 and 10 μm, said pores of said thermoplastic polymer having a mean diameter of substantially between 0.1 and 1 μm.
Claim 5
Dependent Claim
21 words
A composite body as defined in claim 1, wherein said carrier composed of microporous polymer is formed as a hollow fiber.
Claim 6
Dependent Claim
34 words
A composite body as defined in claim 4, wherein said hollow fiber has a smooth outer surface provided with a plurality of openings, said openings occupying between 10 and 90% of said outer surface.
Claim 7
Dependent Claim
21 words
A composite body as defined in claim 1, wherein said carrier composed of microporous polymer is formed as a powder carrier.
Claim 8
Dependent Claim
16 words
A composite body as defined in claim 1, wherein said carrier is composed of microporous polypropylene.
Claim 9
Dependent Claim
25 words
A composite body as defined in claim 1, wherein said carrier composed of microporous polymer has a hollow space occupying substantially between 10 and 90%.
Claim 10
Dependent Claim
25 words
A composite body as defined in claim 8, wherein said hollow space of said carrier composed of microporous polymer occupies substantially between 70 and 80%.
Claim 11
Dependent Claim
39 words
A composite body for long-term delivery of peptides, comprising a carrier for peptide and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a peptide accommodated in said microporous carrier.
Claim 12
Dependent Claim
39 words
A composite body for long-term delivery of peptides, comprising a carrier for peptide and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a peptide accommodated in said microporous carrier.
Claim 13
Dependent Claim
39 words
A composite body for long-term delivery of hormones, comprising a carrier for hormone and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a hormone accommodated in said microporous carrier.
Claim 14
Dependent Claim
39 words
A composite body for long-term delivery of hormones, comprising a carrier for hormone and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a hormone accommodated in said microporous carrier.
Claim 15
Dependent Claim
39 words
A composite body for long-term delivery of neurotransmitters, comprising a carrier for neurotransmitter and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a neurotransmitter accommodated in said microporous carrier.
Claim 16
Dependent Claim
39 words
A composite body for long-term delivery of neurotransmitters, comprising a carrier for neurotransmitter and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a neurotransmitter accommodated in said microporous carrier.
Claim 17
Dependent Claim
39 words
A composite body for long-term delivery of vasopressin, comprising a carrier for vasopressin and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a vasopressin accommodated in said microporous carrier.
Claim 18
Dependent Claim
39 words
A composite body for long-term delivery of vasopressin, comprising a carrier for vasopressin and composed of microporous thermoplastic polymer; a coating composed of cellulose nitrate in contact with said microporous polymer; and a vasopressin accommodated in said microporous carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-24 | 1988-12-24 | 1989-06-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-24 | 1992-12-24 | 1993-06-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-24 | 1996-12-24 | 1997-06-25 | $7700.00 | Window Closed / Lapsed |