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US4521428A
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Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them
Assignee: Elf Sanofi SA
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Filing: 1983-08-16
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Granted: 1985-06-04
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Expires: 2003-08-16
Abstract
Abstract Novel 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## wherein R is an unsubstituted or by an alkyl group of from 1 to 4 carbon atoms substituted pyridyl, pyridyl 1-oxide or naphthyl group and Alk is a straight or branched chain alkylene group of from 2 to 4 carbon atoms are anorexigenic agents useful for treating obesity.
Inventors
- 👤 Dino Nisato
- 👤 Marco Frigerio
- 👤 Giovanna F. Miranda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:04
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06; A; A61; A61P; A61P3/00; A61P3/04; C07D211/00; C07D211/04; C07D211/68; C07D211/70
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
54 words
A 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine of formula ##STR6## wherein R represents an unsubstituted or by an alkyl group of from 1 to 4 carbon atoms substituted pyridyl, pyridyl 1-oxide or naphthyl group and Alk represents a straight or branched chain alkylene group of from 2 to 4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
54 words
A 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine of formula ##STR6## wherein R represents an unsubstituted or by an alkyl group of from 1 to 4 carbon atoms substituted pyridyl, pyridyl 1-oxide or naphthyl group and Alk represents a straight or branched chain alkylene group of from 2 to 4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
11 words
The 4-[2-[4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]ethyl]pyridine 1-oxide or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
11 words
The 4-[2-[4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]ethyl]pyridine 1-oxide or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
4 words
The 4-[2-[4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]ethyl]pyridine 1-oxide hydrochloride.
Claim 6
Dependent Claim
4 words
The 4-[2-[4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1-yl]ethyl]pyridine 1-oxide hydrochloride.
Claim 7
Dependent Claim
3 words
The 1-[2-(2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 8
Dependent Claim
3 words
The 1-[2-(2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 9
Dependent Claim
3 words
The 1-[2-(3-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 10
Dependent Claim
3 words
The 1-[2-(3-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 11
Dependent Claim
3 words
The 1-[2-(4-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 12
Dependent Claim
3 words
The 1-[2-(4-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 13
Dependent Claim
3 words
The 1-[2-(6-methyl-2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 14
Dependent Claim
3 words
The 1-[2-(6-methyl-2-pyridyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 15
Dependent Claim
3 words
The 1-[2-(1-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 16
Dependent Claim
3 words
The 1-[2-(1-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 17
Dependent Claim
3 words
The 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 18
Dependent Claim
3 words
The 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride.
Claim 19
Dependent Claim
29 words
A pharmaceutical composition having anorexigenic activity containing an effective amount of a compound as claimed in any one of claims 1 to 9 in admixture with a pharmaceutical carrier.
Claim 20
Dependent Claim
14 words
A pharmaceutical composition as claimed in claim 10, which is in dosage unit form.
Claim 21
Dependent Claim
24 words
A pharmaceutical composition as claimed in claim 11 in which the amount of active ingredient is from 1 to 500 mg per dosage unit.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-03 | 1988-12-03 | 1989-06-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-03 | 1992-12-03 | 1993-06-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-03 | 1996-12-03 | 1997-06-04 | $7700.00 | Window Closed / Lapsed |