Patent US4513008A successfully refreshed from Google Patents.
US4513008A
Expired / Lapsed
US
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Virucidal compositions and therapy
Assignee: Vinoxen Co
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Filing: 1982-07-30
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Granted: 1985-04-23
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Expires: 2002-07-30
Abstract
Abstract A method of inactivating enveloped virus comprises contacting said virus with a virucidally effective amount of a C20-24 linear polyunsaturated acid, aldehyde or primary alcohol having 5-7 double bonds, a pharmaceutically acceptable salt of said acid, or a mixture thereof. Topical administration of the virucide is preferred and is effective in treating lesions associated with herpes infections. Pharmaceutical compositions for use in the present method are provided.
Inventors
- 👤 Emanuel Revici
- 👤 Bob E. Sherwood
- 👤 Herman P. Benecke
- 👤 John M. Rice
- 👤 Richard W. Geisler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/20; A61K31/045; A61K31/11
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
42 words
A method of inactivating enveloped virus, which comprises contacting said virus with a virucidally effective amount of a C 20-24 linear polyunsaturated acid, aldehyde or primary alcohol having 5-7 double bonds, a pharmaceutically acceptable salt of said acid, or a mixture thereof.
Claim 2
Independent Claim
42 words
A method of inactivating enveloped virus, which comprises contacting said virus with a virucidally effective amount of a C 20-24 linear polyunsaturated acid, aldehyde or primary alcohol having 5-7 double bonds, a pharmaceutically acceptable salt of said acid, or a mixture thereof.
Claim 3
Dependent Claim
26 words
The method of claim 1, wherein the virucidal agent is a C 20-24 linear polyunsaturated acid having 5-7 double bonds or a mixture of said acids.
Claim 4
Dependent Claim
19 words
The method of claim 2, wherein said acid is eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) or a mixture thereof.
Claim 5
Dependent Claim
12 words
The method of claim 2, wherein the acids are 5,8,11,14,17-EPA and 4,7,10,13,16,19-DHA.
Claim 6
Independent Claim
13 words
The method of any of claims 1-4, wherein the virus is herpes simplex.
Claim 7
Independent Claim
15 words
The method of any of claims 1-4, wherein the virus is herpes simplex type 2.
Claim 8
Dependent Claim
29 words
The method of claim 5, wherein the virucidal agent is applied topically to reduce or inhibit lesions in an animal or human suffering from a herpes simplex virus infection.
Claim 9
Dependent Claim
16 words
The method of claim 1, wherein said effective amount is about 0.001 mg-1 g per administration.
Claim 10
Dependent Claim
15 words
The method of claim 7, wherein said effective amount is about 0.1-100 mg per application.
Claim 11
Dependent Claim
28 words
The method of claim 2, wherein said acid is applied as a topical preparation having a triglycerides content of less than 50% by weight relative to said acids.
Claim 12
Dependent Claim
13 words
The method of claim 10, wherein said triglycerides content is less than 30%.
Claim 13
Dependent Claim
17 words
The method of claim 10, wherein said topical preparation is substantially free of triglycerides of said acids.
Claim 14
Independent Claim
19 words
The method of any of claims 10-12, wherein said topical preparation is an ointment, cream, salve, gel or lotion.
Claim 15
Dependent Claim
12 words
The method of claim 13, wherein said topical preparation is an ointment.
Claim 16
Dependent Claim
28 words
The method of claim 14, wherein said effective amount is about 0.01-50 mg of virucide per cc of ointment base, and about 0.01-100 mg of virucide per dose.
Claim 17
Dependent Claim
26 words
The method of claim 15, wherein about 0.1-10 mg of EPA, DHA or a mixture thereof per cc of ointment base is present in said preparation.
References Cited (Backward Citations)
US4097602A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1988-04-22 | 1988-10-22 | 1989-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-22 | 1992-10-22 | 1993-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-22 | 1996-10-22 | 1997-04-23 | $7700.00 | Window Closed / Lapsed |