Abstract The present invention relates to a method of controlling the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D 3 -26,23-lactones expressed by the following formula (I) ##STR1## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--, to warm-blooded animals, and a pharmaceutical composition to be used for controlling the concentration of calcium in the serum of warm-blooded animals which comprises 25-hydroxyvitamin D 3 -26,23-lactones expressed by the above-mentioned formula (I) and a pharmaceutically acceptable carrier. 25-hydroxyvitamin D 3 -26,23-lactones are desirably used especially for the treatment or prevention of the diseases resulting from the high calcium levels in the serum.
A method to decrease the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D 3 -26,23-lactones expressed by the following formula (I) to warm-blooded animals ##STR8## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--.
Claim 2
Independent Claim
54 words
A method to decrease the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D 3 -26,23-lactones expressed by the following formula (I) to warm-blooded animals ##STR8## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--.
Claim 3
Dependent Claim
17 words
A method according to claim 1, wherein said 25-hydroxyvitamin D 3 -26,23-lactones is 1α,25-dihydroxyvitamin D 3 -26,23-lactone.
Claim 4
Dependent Claim
18 words
A method according to claim 1, wherein said pharmaceutically effective amount is 5 ng to 200 ng/kg--body weight/day.
Claim 5
Independent Claim
17 words
A method according to any of claims 1, 2 or 3, wherein said warm-blooded animal is man.
Claim 6
Dependent Claim
18 words
A method according to claim 2, wherein said 25-hydroxyvitamin D 3 -26,23-lactones is 23(S), 25(R)--1α,25-dihydroxyvitamin D 3 -26,23-lactone.
Claim 7
Dependent Claim
18 words
A method according to claim 2, wherein said pharmaceutically effective amount is 5 ng to 200 ng/kg--body weight/day.
Claim 8
Dependent Claim
18 words
A method according to claim 5, wherein said pharmaceutically effective amount is 5 ng to 200 ng/kg--body weight/day.