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US4511564A Expired / Lapsed US ⏱️ 0.0 years remaining

Methods of controlling the concentration of calcium in the serum of warm-blooded animals and pharmaceutical compositions to be used therefor

Assignee: Teijin Ltd
•
Filing: 1982-12-29
•
Granted: 1985-04-16
•
Expires: 2002-12-29
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Abstract

Abstract The present invention relates to a method of controlling the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D 3 -26,23-lactones expressed by the following formula (I) ##STR1## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--, to warm-blooded animals, and a pharmaceutical composition to be used for controlling the concentration of calcium in the serum of warm-blooded animals which comprises 25-hydroxyvitamin D 3 -26,23-lactones expressed by the above-mentioned formula (I) and a pharmaceutically acceptable carrier. 25-hydroxyvitamin D 3 -26,23-lactones are desirably used especially for the treatment or prevention of the diseases resulting from the high calcium levels in the serum.

Inventors

  • 👤 Seiichi Ishizuka
  • 👤 Junji Kubo

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 07:12
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; C07D307/33; C07D319/00; C07D319/02

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 54 words
A method to decrease the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D 3 -26,23-lactones expressed by the following formula (I) to warm-blooded animals ##STR8## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--.
Claim 2
Independent Claim 54 words
A method to decrease the concentration of calcium in the serum of warm-blooded animals characterized by the administration of a pharmaceutically effective amount of 25-hydroxyvitamin D 3 -26,23-lactones expressed by the following formula (I) to warm-blooded animals ##STR8## wherein R indicates a hydrogen atom or a hydroxyl group and X indicates --O-- or --O--O--.
Claim 3
Dependent Claim 17 words
A method according to claim 1, wherein said 25-hydroxyvitamin D 3 -26,23-lactones is 1α,25-dihydroxyvitamin D 3 -26,23-lactone.
Claim 4
Dependent Claim 18 words
A method according to claim 1, wherein said pharmaceutically effective amount is 5 ng to 200 ng/kg--body weight/day.
Claim 5
Independent Claim 17 words
A method according to any of claims 1, 2 or 3, wherein said warm-blooded animal is man.
Claim 6
Dependent Claim 18 words
A method according to claim 2, wherein said 25-hydroxyvitamin D 3 -26,23-lactones is 23(S), 25(R)--1α,25-dihydroxyvitamin D 3 -26,23-lactone.
Claim 7
Dependent Claim 18 words
A method according to claim 2, wherein said pharmaceutically effective amount is 5 ng to 200 ng/kg--body weight/day.
Claim 8
Dependent Claim 18 words
A method according to claim 5, wherein said pharmaceutically effective amount is 5 ng to 200 ng/kg--body weight/day.

References Cited (Backward Citations)

US4307231A Cited
US4336193A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-04-15 1988-10-15 1989-04-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-04-15 1992-10-15 1993-04-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-04-15 1996-10-15 1997-04-16 $7700.00 Window Closed / Lapsed

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