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US4508708A
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Virus vaccines and process for preparing the same
Assignee: Government of Netherlands
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Filing: 1982-06-02
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Granted: 1985-04-02
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Expires: 2002-06-02
Abstract
Abstract The invention relates to virus vaccines and to a process for the preparation thereof especially to polio virus vaccines and other picorna virus vaccines, such as foot-and-mouth disease vaccine. The invention provides vaccines which are stabilized and show an improved activity by the addition of compounds of formula I of the formula sheet, in which R1 en R2 each represent an alkyl- or alkoxy group of not more than 6 carbon atoms, preferably not more than 4 carbon atoms, A represents a bivalent hydrocarbon radical of 3-12 carbon atoms, R3 represents an unsubstituted or substituted phenyl radical and n is 1 or 0.
Inventors
- 👤 Antonius L. Van Wezel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:22
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/125; A61K39/135; A61K39/13; A61K2039/51; A61K2039/525; A61K2039/5252; A61K2039/555; A61K2039/55511; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/32011; C12N2770/32611; C12N2770/32634; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
88 words
Vaccine containing one or more picorna virus antigens in the form of inactivated picorna virus or virus polypeptide thereof, free from live virus and containing a stabilizingly effective amount of at least one compound of formula 1 ##STR1## in which R 1 and R 2 each represent an alkyl or alkoxy group of not more than 6 carbon atoms, A represents a bivalent hydrocarbon radical of 3-12 carbon atoms, R 3 represents an unsubstituted or substituted phenyl radical and n represents one of the figures 0 or 1.
Claim 2
Dependent Claim
88 words
Vaccine containing one or more picorna virus antigens in the form of inactivated picorna virus or virus polypeptide thereof, free from live virus and containing a stabilizingly effective amount of at least one compound of formula 1 ##STR1## in which R 1 and R 2 each represent an alkyl or alkoxy group of not more than 6 carbon atoms, A represents a bivalent hydrocarbon radical of 3-12 carbon atoms, R 3 represents an unsubstituted or substituted phenyl radical and n represents one of the figures 0 or 1.
Claim 3
Dependent Claim
61 words
Vaccine according to claim 1, containing a compound of formula 1 in which R 1 and R 2 each represent an alkyl or alkoxy group of 1 or 2 carbon atoms, A represents a straight alkylene radical of 6 or 7 carbon atoms and R 3 represents a phenyl radical substituted with one or more halogen atoms, alkoxy or nitro groups.
Claim 4
Dependent Claim
35 words
Vaccine according to claim 2 containing a compound of formula 1 in which R 1 and R 2 each represent an ethyl radical. A represents the hexamethylene radical and R 3 represents the 2-chloro-4-methoxyphenyl radical.
Claim 5
Dependent Claim
16 words
Vaccine according to claim 1 containing at least 0.1 μg/ml of a compound of formula 1.
Claim 6
Dependent Claim
18 words
Vaccine according to claim 1 in which the antigens are present in the form of inactivated polio virus.
Claim 7
Dependent Claim
29 words
Vaccine according to claim 5, in which the antigens are present in the form of a mixture of inactivated polio virus of the strains Mahoney, MEF 1 and Saukett.
Claim 8
Dependent Claim
21 words
Vaccine according to claim 1, in which the antigens are present in the form of one or more picorna virus polypeptides.
Claim 9
Dependent Claim
26 words
Vaccine according to claim 7, in which the virus polypeptides are polio virus polypeptides VP 1 , VP 2 , VP 3 and/or VP 4 .
Claim 10
Dependent Claim
55 words
In a process for adjuvanting a picorna virus vaccine the improvement which consists essentially of the steps of adding as a stabilizingly effective adjuvant a compound of formula 1 as defined in claim 1 to a suspension or solution of one or more inactivated picorna virus or virus polypeptide thereof antigens free from live virus.
Claim 11
Dependent Claim
22 words
The process of claim 9, characterized by adding a compound of formula 1 to obtain a concentration of at least 0.1 μg/ml.
Claim 12
Dependent Claim
20 words
The process of claim 9, characterized by adding a compound of formula 1 to a suspension of inactivated polio virus.
Claim 13
Dependent Claim
24 words
The process of claim 9, characterized by adding a compound of formula 1 to a suspension of live polio virus and inactivating the same.
Claim 14
Dependent Claim
25 words
The process of claim 9, characterized by adding a compound of formula 1 to a suspension of solution of one or more picorna virus polypeptides.
Claim 15
Dependent Claim
32 words
The process of claim 13, characterized in that the virus polypeptides are one or more of the polio virus polypeptides VP 1 , VP 2 , VP 3 and VP 4 .
Claim 16
Dependent Claim
60 words
The process of claim 9 wherein in the compound of formula 1 R 1 and R 2 each represent an alkyl or alkoxy group of 1 or 2 carbon atoms, A represents a straight alkylene radical of 6 or 7 carbon atoms and R 3 represents a phenyl radical substituted with one or more halogen atoms, alkoxy or nitro groups.
Claim 17
Dependent Claim
33 words
The process of claim 15 wherein the compound of formula 1 R 1 and R 2 each represent an ethyl radical, A represents the hexamethylene radical and R 3 represents the 2-chloro-4-methoxyphenyl radical.
Claim 18
Dependent Claim
17 words
A vaccine according to claim 3 containing at least 0.1 μg/ml of a compound of formula 1.
Claim 19
Dependent Claim
15 words
A vaccine according to claim 1 which is a foot and mouth disease virus vaccine.
Claim 20
Dependent Claim
15 words
A vaccine according to claim 2 which is a foot and mouth disease virus vaccine.
Claim 21
Dependent Claim
15 words
A vaccine according to claim 3 which is a foot and mouth disease virus vaccine.
Claim 22
Dependent Claim
16 words
A process according to claim 9 wherein the vaccine is a foot and mouth disease vaccine.
Claim 23
Dependent Claim
12 words
A vaccine according to claim 2 which is a polio virus vaccine.
Claim 24
Dependent Claim
12 words
A vaccine according to claim 3 which is a polio virus vaccine.
Claim 25
Dependent Claim
49 words
In a process for adjuvanting a picorna virus vaccine, the improvement which consists essentially of the step of adding as a stabilizingly effective adjuvant a compound of formula 1 of claim 1 to a suspension or solution of one or more live virus antigens and inactivating the live virus.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-01 | 1988-10-01 | 1989-04-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-01 | 1992-10-01 | 1993-04-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-01 | 1996-10-01 | 1997-04-02 | $7700.00 | Window Closed / Lapsed |