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Preparation of anthralin solutions or suspensions in aromatic esters and their use for diseases of the skin and nails

Assignee: L'Oréal SA
•
Filing: 1983-01-20
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Granted: 1985-03-12
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Expires: 2003-01-20
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Abstract

Abstract An oxidation-stable composition is useful for the treatment of diseases of the skin and nails, which comprises a solution of dispersion of anthralin in an aromatic ester of the formula: ##STR1## wherein R represents H, OH, CH 3 , or OCH 3 , n is 1 or 2; R 1 represents a linear or branched alkyl radical having 1 to 18 carbon atoms; a cycloalkyl radical having 4 to 6 carbon atoms which is optionally substituted by an alkyl radical having 1 to 3 carbon atoms; an arylalkyl or arylalkenyl radical in which the alkyl or alkenyl radical has 1 to 3 carbon atoms; or a phenyl radical optionally substituted by an alkyl radical having 1 to 3 carbon atoms or by an alkoxy radical having 1 or 2 carbon atoms; X represents the divalent radical --CH 2 --, --CH 2 --CH 2 --, or --CH═C--; and t is 0 or 1.

Inventors

  • 👤 Jean F. Grollier
  • 👤 Georges Rosenbaum
  • 👤 Josiane Allec
  • 👤 Braham Shroot

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-09 17:23
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K31/00; A61K31/21; A61K31/215; A61K31/235; A61K31/60; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/34; A61K8/347; A61K8/37; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P17/00; A61P43/00; A61Q; A61Q19/00; A61Q3/00; A61Q5/00; A61Q5/02

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 62 words
An oxidation stable composition for the treatment of skin diseases, comprising a solution or dispersion containing 0.01 to 5% by weight of anthralin in an aromatic ester of the formula: ##STR3## wherein R represents H, OH, CH 3 , or OCH 3 , n is 1 or 2; and R 1 represents phenyl, (C 1 -C 3 ) alkyl phenyl, or benzyl.
Claim 2
Dependent Claim 62 words
An oxidation stable composition for the treatment of skin diseases, comprising a solution or dispersion containing 0.01 to 5% by weight of anthralin in an aromatic ester of the formula: ##STR3## wherein R represents H, OH, CH 3 , or OCH 3 , n is 1 or 2; and R 1 represents phenyl, (C 1 -C 3 ) alkyl phenyl, or benzyl.
Claim 3
Dependent Claim 18 words
A composition according to claim 1 wherein the anthralin is present in a concentration of 0.05 to 2.5%.
Claim 4
Dependent Claim 22 words
A composition according to claim 1 wherein the aromatic ester is selected from the group consisting of benzyl benzoate and benzyl salicylate.
Claim 5
Dependent Claim 25 words
A composition according to claim 1 wherein the composition additionally contains a thickener selected from the group consisting of silica, polyethylene powder and nylon powder.
Claim 6
Dependent Claim 28 words
A process for the treatment of skin diseases which comprises topically applying to the lesions to be treated an effective amount of a composition according to claim 1.
Claim 7
Dependent Claim 13 words
The process of claim 5 wherein the disease to be treated is psoriasis.
Claim 8
Dependent Claim 40 words
The process of claim 5 wherein the composition containing anthralin constitutes the active ingredient of the first part of a two-part package, the second part being a cosmetic base and the two parts being mixed at the moment of use.

References Cited (Backward Citations)

US4326224A Cited
US4293544A Cited
US4299826A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-03-11 1988-09-10 1989-03-12 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-03-11 1992-09-10 1993-03-12 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-03-11 1996-09-10 1997-03-12 $7700.00 Window Closed / Lapsed

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