US4501893A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-{6-[3-Pyrrolidino-1-(4-tolyl)prop-1-enyl]-2-pyridyl}acrylic acid and pharmaceutically acceptable salts thereof
Assignee: SmithKline Beecham Corp
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Filing: 1983-02-01
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Granted: 1985-02-26
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Expires: 2003-02-01
Abstract
Abstract This disclosure describes a compound of Formula I <IMAGE> I (including its pharmaceutically acceptable salts and esters) which has potent antihistamine activity which is substantially free from sedative effects and which has little or no anticholinergic effects.
Inventors
- 👤 John W. A. Findlay
- 👤 Geoffrey G. Coker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:44
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/47; A61K31/485; A61P; A61P11/00; A61P37/00; A61P37/08; A61P43/00; C07D213/24; C07D213/54; C07D213/55; C07D213/56; C07D213/61; C07D295/00; C07D295/04; C07D295/14; C07D295/155; C07D405/00; C07D405/02; C07D405/04
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
20 words
The compound of formula (I) ##STR10## straight and branched lower alkyl (1-4 carbon atoms) esters, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
20 words
The compound of formula (I) ##STR10## straight and branched lower alkyl (1-4 carbon atoms) esters, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
9 words
The compound of claim 1 as the hydrochloride salt.
Claim 4
Dependent Claim
9 words
The compound of claim 1 as the sulfate salt.
Claim 5
Dependent Claim
9 words
The compound of claim 1 as the hydrobromide salt.
Claim 6
Dependent Claim
9 words
The compound of claim 1 as the tartrate salt.
Claim 7
Dependent Claim
9 words
The compound of claim 1 as the citrate salt.
Claim 8
Dependent Claim
9 words
The compound of claim 1 as the succinate salt.
Claim 9
Dependent Claim
9 words
The compound of claim 1 as the sodium salt.
Claim 10
Dependent Claim
9 words
The compound of claim 1 as the potassium salt.
Claim 11
Dependent Claim
9 words
The compound of claim 1 as the calcium salt.
Claim 12
Dependent Claim
10 words
The compound of claim 1 which is the methyl ester.
Claim 13
Dependent Claim
10 words
The compound of claim 1 which is the ethyl ester.
Claim 14
Dependent Claim
10 words
The compound of claim 1 which is the propyl ester.
Claim 15
Dependent Claim
10 words
The compound of claim 1 which is the butyl ester.
Claim 16
Dependent Claim
2 words
(E)-3-{6-[3-Pyrrolidino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid.
Claim 17
Dependent Claim
2 words
(E)-3-{6-[3-Pyrrolidino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid.
Claim 18
Dependent Claim
12 words
The compound of formula (I) ##STR11## or a pharmaceutically acceptable salt thereof.
Claim 19
Dependent Claim
12 words
The compound of formula (I) ##STR11## or a pharmaceutically acceptable salt thereof.
Claim 20
Dependent Claim
7 words
A pharmaceutically acceptable salt of (E)-3-{6-[3-Pyrrolidino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid.
Claim 21
Dependent Claim
7 words
A pharmaceutically acceptable salt of (E)-3-{6-[3-Pyrrolidino-1-(4-tolyl)prop-1E-enyl]-2-pyridyl}acrylic acid.
Claim 22
Dependent Claim
6 words
The hydrochloride salt of claim 17.
Claim 23
Dependent Claim
11 words
The salt of claim 17 which is an acid addition salt.
Claim 24
Dependent Claim
14 words
The salt of claim 17 which is an alkaline metal or alkaline earth salt.
Claim 25
Dependent Claim
6 words
The tartrate salt of claim 17.
References Cited (Backward Citations)
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Cited
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Cited
GB807757A
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Cited
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Cited
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-26 | 1988-08-27 | 1989-02-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-26 | 1992-08-27 | 1993-02-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-26 | 1996-08-27 | 1997-02-26 | $7700.00 | Window Closed / Lapsed |