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US4500700A
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Elastomeric composite material comprising a polypentapeptide having an amino acid of opposite chirality in position three
Assignee: ALABAMA FOR UNIVERSITY OF ALABAMA IN BIRMINGHAM, University of, Trustees of
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Filing: 1982-12-23
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Granted: 1985-02-19
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Expires: 2002-12-23
Abstract
Abstract An elastomeric material comprising an elastomeric polypeptide, where the polypeptide comprises pentapeptide repeating units formed of amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues where the third amino acid residue of at least one repeating unit of the polypeptide has the D configuration if the remaining hydrophobic amino acids have the L configuration or the L configuration if the remaining hydrophobic amino acid residues have the D configuration and where the repeating units exist in a conformation having a β-turn. Also disclosed are elastomeric fabrics formed from the elastomeric material and composites containing it and the use of such fabrics in vascular prosthesis, as well as a method of forming such elastomeric materials.
Inventors
- 👤 Dan W. Urry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:06
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/29; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31725; Y10T428/31739
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
170 words
An elastomeric material, comprising: an elastomeric polypeptide, wherein said polypeptide comprises pentapeptide repeating units consisting of a first amino carboxylic acid residue, a second amino carboxylic acid residue, a third amino carboxylic acid residue, a fourth amino carboxylic acid residue and a fifth amino carboxylic acid residue, wherein said repeating units comprise amino carboxylic acid residues selected from the group consisting of hydrophobic amino carboxylic acid and glycine residues wherein said residues are amino carboxylic acids which are missing a hydrogen of an amino group and a hydroxyl of a carboxyl group, wherein the third amino carboxylic acid residue of at least one repeating unit of said polypeptide has a D configuration if the first, second, fourth and fifth hydrophobic amino carboxylic acid residues which are not glycine residues have the L configuration or the L configuration if the first, second, fourth and fifth hydrophobic amino carboxylic acid residues which are not glycine residues have the D configuration and wherein said repeating units exist in a conformation having a β-turn.
Claim 2
Dependent Claim
170 words
An elastomeric material, comprising: an elastomeric polypeptide, wherein said polypeptide comprises pentapeptide repeating units consisting of a first amino carboxylic acid residue, a second amino carboxylic acid residue, a third amino carboxylic acid residue, a fourth amino carboxylic acid residue and a fifth amino carboxylic acid residue, wherein said repeating units comprise amino carboxylic acid residues selected from the group consisting of hydrophobic amino carboxylic acid and glycine residues wherein said residues are amino carboxylic acids which are missing a hydrogen of an amino group and a hydroxyl of a carboxyl group, wherein the third amino carboxylic acid residue of at least one repeating unit of said polypeptide has a D configuration if the first, second, fourth and fifth hydrophobic amino carboxylic acid residues which are not glycine residues have the L configuration or the L configuration if the first, second, fourth and fifth hydrophobic amino carboxylic acid residues which are not glycine residues have the D configuration and wherein said repeating units exist in a conformation having a β-turn.
Claim 3
Dependent Claim
26 words
The elastomeric material of claim 1, wherein said hydrophobic amino carboxylic acid residues are selected from the group consisting of residues of hydrophobic α-amino carboxylic acids.
Claim 4
Dependent Claim
30 words
The elastomeric material of claim 2, wherein said hydrophobic amino carboxylic acid residues are selected from the group consisting of alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan, and methionine residues.
Claim 5
Dependent Claim
25 words
The elastomeric material of claim 3, wherein the first amino carboxylic acid residue of said repeating unit is a residue of valine, leucine, or isoleucine.
Claim 6
Dependent Claim
22 words
The elastomeric material of claim 3, wherein the second amino carboxylic acid residue of said repeating unit is a residue of proline.
Claim 7
Dependent Claim
40 words
The elastomeric material of claim 3, wherein the third amino carboxylic acid residue of said repeating unit is a residue of a hydrophobic amino carboxylic acid having no more than 10 carbon atoms in the side chain of said residue.
Claim 8
Dependent Claim
22 words
The elastomeric material of claim 3, wherein the fourth amino carboxylic acid residue of said repeating unit is a residue of valine.
Claim 9
Dependent Claim
22 words
The elastomeric material of claim 3, wherein the fifth amino carboxylic acid residue of said repeating unit is a residue of glycine.
Claim 10
Dependent Claim
14 words
The elastomeric material of claim 1, wherein said repeating unit is L-Val-L-Pro-D-Ala-L-Val-Gly or D-Val-D-Pro-L-Ala-D-Val-Gly.
References Cited (Backward Citations)
US4132746A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-19 | 1988-08-20 | 1989-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-19 | 1992-08-20 | 1993-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-19 | 1996-08-20 | 1997-02-19 | $7700.00 | Window Closed / Lapsed |