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Patent US4499105A successfully refreshed from Google Patents.
US4499105A
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Carboxyimidamide derivatives
Assignee: Akzo NV
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Filing: 1982-12-28
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Granted: 1985-02-12
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Expires: 2002-12-28
Abstract
Abstract The present invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which n and m represent the number 1 or 2, X and Y hydrogen, alkyl (1-4 C), alkoxy (1-4 C), hydroxy, halogen, hydroxymethyl, trifluoromethyl, acyl (1-4 C), acyloxy (1-4 C) or the group NR x R y , in which R x and R y represent hydrogen, alkyl (1-4 C) or a sulphonyl group and R represents the group ##STR2## in which R 1 and R 2 represent hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C), phenylalkoxy (7-10 C), acyloxy, amino or mono or dialkyl (1-4 C) amino, having potent platelet aggregation inhibiting properties.
Inventors
- 👤 Harm J. Panneman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:30
CPC Classifications
C; C07; C07C; C07C311/00; C07C311/15; C07C311/21; A; A61; A61P; A61P7/00; C07C257/00; C07C257/10; C07C257/16; C07C257/22; C07C259/00; C07C259/12; C07C259/16; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/10; C07C2602/12; C07C2602/14; C07C2602/24
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
101 words
Carboximidamide derivatives of the general formula: ##STR13## in which n and m represent the value 1 or 2, X and Y hydrogen, alkyl (1-4 C), alkoxy (1-4 C), hydroxy, halogen, hydroxymethyl, trifluoromethyl, acyl (1-4 C), acyloxy (1-4 C) or the group NR x R y , in which R x and R y represent hydrogen, alkyl (1-4 C) or a sulphonyl group and R represents the group: ##STR14## in which R 1 and R 2 represent hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C), phenylalkoxy (7-10 C), acyloxy, amino or mono- or dialkyl (1-4 C)-amino, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
101 words
Carboximidamide derivatives of the general formula: ##STR13## in which n and m represent the value 1 or 2, X and Y hydrogen, alkyl (1-4 C), alkoxy (1-4 C), hydroxy, halogen, hydroxymethyl, trifluoromethyl, acyl (1-4 C), acyloxy (1-4 C) or the group NR x R y , in which R x and R y represent hydrogen, alkyl (1-4 C) or a sulphonyl group and R represents the group: ##STR14## in which R 1 and R 2 represent hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C), phenylalkoxy (7-10 C), acyloxy, amino or mono- or dialkyl (1-4 C)-amino, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
47 words
A compound according to claim 1 of the formula: ##STR15## in which X and Y have the meanings indicated in claim 1, m and n have both the value 1 or the value 2 and R 1 is selected from ##STR16## or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
23 words
A compound according to claim 2, in which one of the symbols X and Y or both have a meaning other than hydrogen.
Claim 5
Dependent Claim
21 words
A compound according to claim 3 in which one or both of the symbols X and Y represent an alkoxy group.
Claim 6
Dependent Claim
15 words
Compound in accordance with claim 1 having the formula: ##STR17## or a pharmaceutically-acceptable salt thereof.
Claim 7
Dependent Claim
41 words
A pharmaceutical composition for use as a blood platelet aggregation inhibitor which comprises, as active ingredient, a blood platelet aggregation inhibiting amount of a compound as defined in claim 1, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-12 | 1988-08-13 | 1989-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-12 | 1992-08-13 | 1993-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-12 | 1996-08-13 | 1997-02-12 | $7700.00 | Window Closed / Lapsed |