US4497847A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for coating solid pharmaceutical preparations and coated preparations thus obtained
Assignee: Sankyo Co Ltd
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Filing: 1983-10-11
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Granted: 1985-02-05
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Expires: 2003-10-11
Abstract
Abstract A plasticizer for film-forming enteric polymers to be used in coating solid pharmaceutical preparations comprises a monoester or diester or both of glycerol with a saturated aliphatic carboxylic acid having from 6 to 10 carbon atoms. This is particularly useful for coating preparations from aqueous suspensions.
Inventors
- 👤 Kozo Kurihara
- 👤 Izuo Ichikawa
- 👤 Hisanori Nakane
- 👤 Yoshihiko Ikegami
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:48
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866; A61K9/282; A61K9/2826
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
62 words
A process for coating a solid pharmaceutical preparation in which an aqueous suspension of a film-forming enteric polymer and a plasticizer therefor is applied to a surface of said preparation and the aqueous phase is removed, wherein the plasticizer is selected from monoesters, diesters and mixtures thereof of glycerol with a saturated aliphatic carboxylic acid having from 6 to 10 carbon atoms.
Claim 2
Dependent Claim
62 words
A process for coating a solid pharmaceutical preparation in which an aqueous suspension of a film-forming enteric polymer and a plasticizer therefor is applied to a surface of said preparation and the aqueous phase is removed, wherein the plasticizer is selected from monoesters, diesters and mixtures thereof of glycerol with a saturated aliphatic carboxylic acid having from 6 to 10 carbon atoms.
Claim 3
Dependent Claim
22 words
A process as claimed in claim 1, wherein said carboxylic acid is selected from acids having 6, 8 and 10 carbon atoms.
Claim 4
Dependent Claim
13 words
A process as claimed in claim 1, wherein said acid is octanoic acid.
Claim 5
Dependent Claim
110 words
A process as claimed in claim 1, wherein said polymer is selected from the group consisting of carboxymethylethylcellulose, cellulose acetate phthalate, methyl acrylate-methacrylic acid copolymers, starch acetate phthalate, cellulose acetate succinate, styrene-maleic acid copolymers, starch polyacetate, cellulose benzoate phthalate, methylcellulose phthalate, ethylhydroxyethylcellulose phthalate, cellulose acetate maleate, hydroxypropylmethylcellulose phthalate, amylose acetate phthalate, poly(vinyl alcohol)phthalate, polyvinyl acetate phthalate, polyvinyl propionate phthalate, polyvinyl butyrate phthalate, polyvinyl acetacetal succinate, vinyl acetate-phthalic anhydride copolymers, styrene-phthalic anhydride copolymers, vinyl methyl ether-maleic anhydride copolymers, ethylene-maleic anhydride copolymers, acrylonitrile-methyl acrylate-maleic anhydride copolymers, butyl acrylate-styrene-maleic anhydride copolymers, styrene-acrylic acid copolymers, butyl acrylate-styrene-acrylic acid copolymers, styrene-acrylic acid copolymers, butyl acrylate-styrene-methacrylic acid copolymers, cellulose propionate phthalate and methyl methacrylate-methacrylic acid copolymers.
Claim 6
Dependent Claim
21 words
A process as claimed in claim 1, wherein said polymer is selected from the group consisting of carboxymethylethylcellulose and hydroxypropylmethylcellulose phthalate.
Claim 7
Dependent Claim
12 words
A process as claimed in claim 1, wherein said polymer is carboxymethylethylcellulose.
Claim 8
Dependent Claim
76 words
A process for coating a solid pharmaceutical preparation in which an aqueous suspension of a film-forming enteric polymer and a plasticizer therefor is applied to a surface of said preparation and the aqueous phase is removed, wherein the plasticizer is selected from monoesters, diesters and mixtures thereof of glycerol with a saturated aliphatic carboxylic acid having 6, 8 or 10 carbon atoms, the weight ratio of said plasticizer to said polymer being from 0.2:1 to 0.5:1.
Claim 9
Dependent Claim
76 words
A process for coating a solid pharmaceutical preparation in which an aqueous suspension of a film-forming enteric polymer and a plasticizer therefor is applied to a surface of said preparation and the aqueous phase is removed, wherein the plasticizer is selected from monoesters, diesters and mixtures thereof of glycerol with a saturated aliphatic carboxylic acid having 6, 8 or 10 carbon atoms, the weight ratio of said plasticizer to said polymer being from 0.2:1 to 0.5:1.
Claim 10
Dependent Claim
13 words
A process as claimed in claim 7, wherein said acid is octanoic acid.
Claim 11
Dependent Claim
110 words
A process as claimed in claim 7, wherein said polymer is selected from the group consisting of carboxymethylethylcellulose, cellulose acetate phthalate, methyl acrylate-methacrylic acid copolymers, starch acetate phthalate, cellulose acetate succinate, styrene-maleic acid copolymers, starch polyacetate, cellulose benzoate phthalate, methylcellulose phthalate, ethylhydroxyethylcellulose phthalate, cellulose acetate maleate, hydroxypropylmethylcellulose phthalate, amylose acetate phthalate, poly(vinyl alcohol)phthalate, polyvinyl acetate phthalate, polyvinyl propionate phthalate, polyvinyl butyrate phthalate, polyvinyl acetacetal succinate, vinyl acetate-phthalic anhydride copolymers, styrene-phthalic anhydride copolymers, vinyl methyl ether-maleic anhydride copolymers, ethylene-maleic anhydride copolymers, acrylonitrile-methyl acrylate-maleic anhydride copolymers, butyl acrylate-styrene-maleic anhydride copolymers, styrene-acrylic acid copolymers, butyl acrylate-styrene-acrylic acid copolymers, styrene-acrylic acid copolymers, butyl acrylate-styrene-methacrylic acid copolymers, cellulose propionate phthalate and methyl methacrylate-methacrylic acid copolymers.
Claim 12
Dependent Claim
21 words
A process as claimed in claim 7, wherein said polymer is selected from the group consisting of carboxymethylethylcellulose and hydropropylmethylcellulose phthalate.
Claim 13
Dependent Claim
12 words
A process as claimed in claim 7, wherein said polymer is carboxymethylethylcellulose.
Claim 14
Dependent Claim
13 words
A process as claimed in claim 11, wherein said acid is octanoic acid.
Claim 15
Dependent Claim
13 words
A process as claimed in claim 10, wherein said acid is octanoic acid.
Claim 16
Dependent Claim
13 words
A process as claimed in claim 9, wherein said acid is octanoic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-05 | 1988-08-06 | 1989-02-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-05 | 1992-08-06 | 1993-02-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-05 | 1996-08-06 | 1997-02-05 | $7700.00 | Window Closed / Lapsed |