Patent US1120214A successfully refreshed from Google Patents.
Patent US4496544A successfully refreshed from Google Patents.
US4496544A
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Atrial Peptides
Assignee: Washington University in St. Louis
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Filing: 1984-01-10
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Granted: 1985-01-29
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Expires: 2004-01-10
Abstract
Abstract Novel atrial peptides having useful natriuretic activity are disclosed with the following amino acid sequence: R1-cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys -asn-R2 wherein R1=H, ser, ser-ser, and R2=OH, ser, ser-phe-arg, ser-phe-arg-tyr, or the physiologically acceptable salts, esters or amides thereof.
Inventors
- 👤 Philip Needleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:16
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/58; A; A61; A61P; A61P7/00; A61P7/10; A61P9/00; A61P9/08; A61K; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
36 words
A peptide having potent natriuretic activity comprising the following amino acid sequence: R.sub.1 -cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-asn-R.sub.2 wherein R 1 =H, ser, ser-ser, and R 2 =OH, ser, ser-phe-arg, ser-phe-arg-tyr, or the physiologically acceptable salts, esters or amides thereof.
Claim 2
Dependent Claim
36 words
A peptide having potent natriuretic activity comprising the following amino acid sequence: R.sub.1 -cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-asn-R.sub.2 wherein R 1 =H, ser, ser-ser, and R 2 =OH, ser, ser-phe-arg, ser-phe-arg-tyr, or the physiologically acceptable salts, esters or amides thereof.
Claim 3
Dependent Claim
24 words
The peptide of claim 1 wherein R 1 is ser-ser and R 2 is ser and which also exhibits intestinal smooth muscle relaxant activity.
Claim 4
Dependent Claim
24 words
The peptide of claim 1 wherein R 1 is ser and R 2 is ser and which also exhibits intestinal smooth muscle relaxant activity.
Claim 5
Dependent Claim
24 words
The peptide of claim 1 wherein R 1 is H and R 2 is ser and which also exhibits intestinal smooth muscle relaxant activity.
Claim 6
Dependent Claim
24 words
The peptide of claim 1 wherein R 1 is ser-ser and R 2 is OH and which also exhibits intestinal smooth muscle relaxant activity.
Claim 7
Dependent Claim
24 words
The peptide of claim 1 wherein R 1 is ser-ser and R 2 is ser-phe-arg and which also exhibits vascular smooth muscle relaxant activity.
Claim 8
Dependent Claim
24 words
The peptide of claim 1 wherein R 1 is ser-ser and R 2 is ser-phe-arg-tyr and which also exhibits vascular smooth muscle relaxant activity.
Claim 9
Dependent Claim
21 words
A therapeutic composition of matter for producing diuresis or natriuresis comprising a therapeutically effective amount of the peptide of claim 1.
Claim 10
Dependent Claim
29 words
A therapeutic composition of matter for producing intestinal smooth muscle relaxant activity comprising a therapeutically effective amount of the peptide of any of claims 2, 3, 4 or 5.
Claim 11
Dependent Claim
27 words
A therapeutic composition of matter for producing vascular smooth muscle relaxant activity comprising a therapeutically effective amount of the peptide of any of claims 6 or 7.
Claim 12
Dependent Claim
27 words
A method for producing diuresis or natriuresis in a mammal comprising administering to said mammal a therapeutically effective amount of a peptide as defined in claim 1.
Claim 13
Independent Claim
35 words
A method for producing intestinal smooth muscle relaxant activity in a mammal comprising administering to said mammal a therapeutically effective amount of a peptide as defined in any of claims 2, 3, 4 or 5.
Claim 14
Independent Claim
33 words
A method for producing vascular smooth muscle relaxant activity in a mammal comprising administering to said mammal a therapeutically effective amount of a peptide as defined in any of claims 6 or 7.
Claim 15
Dependent Claim
30 words
A therapeutic composition of matter for producing renal vasodilation comprising a therapeutically effective amount of a peptide as defined in claim 1 in which R 2 is ser-phe-arg or ser-phe-arg-tyr.
Claim 16
Dependent Claim
28 words
A therapeutic composition of matter for producing renal vasodilation comprising a therapeutically effective amount of the peptide as defined in claim 14 in which R 1 is ser-ser.
Claim 17
Dependent Claim
34 words
A method for producing renal vasodilation in a mammal comprising administering to said mammal a therapeutically effective amount of a peptide as defined in claim 1 in which R 2 is ser-phe-arg or ser-phe-arg-tyr.
Claim 18
Dependent Claim
32 words
A method for producing renal vasodilation in a mammal comprising administering to said mammal a therepeutically effective amount of a peptide as defined in claim 16 in which R 1 is ser-ser.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-29 | 1988-07-30 | 1989-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-29 | 1992-07-30 | 1993-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-29 | 1996-07-30 | 1997-01-29 | $7700.00 | Window Closed / Lapsed |