Patent US4495174A successfully refreshed from Google Patents.
US4495174A
Expired / Lapsed
US
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Anesthetic polyorganophosphazenes
Assignee: Research Corp
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Filing: 1982-06-21
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Granted: 1985-01-22
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Expires: 2002-06-21
Abstract
Abstract A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and 2-amino-4-picoline radical having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitrogen single bond is disclosed along with medicaments containing such anesthetics.
Inventors
- 👤 Harry R. Allcock
- 👤 Paul E. Austin
- 👤 Thomas X. Neenan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:10
CPC Classifications
C; C08; C08G; C08G79/00; C08G79/02; C08G79/025; A; A61; A61K; A61K31/00; A61K31/74; A61K31/80; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/605
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
69 words
A long-acting, local anesthetic, comprising: a polymeric phosphazene backbone, and an organic radical having local anesthetic activity and an amino functional group on a phenyl ring through which said radical is covalently attached to said phosphazene backbone by a phosphorous-nitrogen single bond, and said organic radical being selected from the group consisting of radicals of benzocaine, butethamine, butyl ester of p-aminobenzoic acid, m-butethamine, procaine, chloroprocaine proparacaine, propoxycaine and tetracaine.
Claim 2
Dependent Claim
69 words
A long-acting, local anesthetic, comprising: a polymeric phosphazene backbone, and an organic radical having local anesthetic activity and an amino functional group on a phenyl ring through which said radical is covalently attached to said phosphazene backbone by a phosphorous-nitrogen single bond, and said organic radical being selected from the group consisting of radicals of benzocaine, butethamine, butyl ester of p-aminobenzoic acid, m-butethamine, procaine, chloroprocaine proparacaine, propoxycaine and tetracaine.
Claim 3
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of benzocaine.
Claim 4
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of butethamine.
Claim 5
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical butyl 4-aminobenzoate.
Claim 6
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of procaine.
Claim 7
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of tetracaine.
Claim 8
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of propoxycaine.
Claim 9
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of proparacaine.
Claim 10
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said organic radical is a radical of chloroprocaine.
Claim 11
Dependent Claim
15 words
The local anesthetic of claim 1, wherein said polymeric phosphazene backbone is a cyclic trimer.
Claim 12
Dependent Claim
23 words
The local anesthetic of claim 1, wherein said polymeric phosphazene backbone is a linear chain containing from 3 to 30,000 ##STR16## repeating units.
Claim 13
Dependent Claim
16 words
The local anesthetic of claim 11, wherein said backbone contains from 100 to 20,000 repeating units.
Claim 14
Dependent Claim
14 words
The local anesthetic of claim 11, wherein said backbone contains about 15,000 repeating units.
Claim 15
Dependent Claim
49 words
A long-acting, local anesthetic, comprising: a polymeric phosphazene backbone, and an organic radical having local anesthetic activity which is an ester of p-aminobenzoic acid and an amino functional group on a phenyl ring through which said radical is covalently attached to said phosphazene backbone by a phosphorous-nitrogen single bond.
Claim 16
Dependent Claim
49 words
A long-acting, local anesthetic, comprising: a polymeric phosphazene backbone, and an organic radical having local anesthetic activity which is an ester of p-aminobenzoic acid and an amino functional group on a phenyl ring through which said radical is covalently attached to said phosphazene backbone by a phosphorous-nitrogen single bond.
Claim 17
Dependent Claim
21 words
The local anesthetic of claim 14, wherein a position on a phenyl ring ortho to said amino functional group is unsubstituted.
Claim 18
Dependent Claim
15 words
The local anesthetic of claim 15, wherein said polymeric phosphazene backbone is a cyclic trimer.
Claim 19
Dependent Claim
22 words
The local anesthetic of claim 15, wherein said polymeric phosphazene backbone is a linear chain containing from 100 to 20,000 repeating units.
Claim 20
Dependent Claim
14 words
The local anesthetic of claim 1, wherein said backbone contains about 15,000 repeating units.
Claim 21
Dependent Claim
24 words
A long-acting local anesthetic medicament, comprising a local anesthetic effective amount of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 22
Dependent Claim
18 words
A long-acting local anesthetic medicament, comprising a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-22 | 1988-07-23 | 1989-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-22 | 1992-07-23 | 1993-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-22 | 1996-07-23 | 1997-01-22 | $7700.00 | Window Closed / Lapsed |