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US4495151A Expired / Lapsed US ⏱️ 0.0 years remaining

Element for immunoassay

Assignee: Toyo Jozo KK
•
Filing: 1982-07-01
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Granted: 1985-01-22
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Expires: 2002-07-01
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Abstract

Abstract Apparatus for performing an immunoassay, comprises in combination a reaction tube closed at its bottom, and in the reaction tube a molded element having on its surface material having specific binding ability for a component in a liquid specimen to be assayed. The shape of the surface of the element adjacent the interior surface of the tube is the complement of the shape of the interior surface of the tube. A spacer rib is provided on the element, in contact with the interior surface of the tube. This rib holds the element in such position in the tube that the surfaces of complementary shape of the element and tube are shaped from each other a small but constant distance. A thin layer of constant thickness of a liquid specimen for immunoassay is thus receivable between the complementary surfaces. This arrangement increases the contact surface of the liquid medium in the reaction tube by the element, by establishing a homogeneous uniform layer of liquid medium. This avoids the need for stirring and shaking and reduces the required volume of the specimen to be assayed.

Inventors

  • 👤 Kunio Ohyama
  • 👤 Nobuaki Nakagawa
  • 👤 Susumu Watanabe

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 12:47
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; Y; Y10; Y10S; Y10S436/00; Y10S436/807; Y10S436/81

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 139 words
In apparatus for performing an immunoassay, comprising in combination a reaction tube closed at its bottom, and in the reaction tube a molded element having on its surface material having specific binding ability for a component in a liquid specimen to be assayed; the improvement in which the shape of the surface of the element adjacent the interior surface of the tube is the complement of the shape of the interior surface of the tube, and spacer means on the element in contact with the interior surface of the tube, said spacer means holding the element in such position in the tube that said surfaces of complementary shape are spaced from each other a small but constant distance thereby to receive between said surfaces of complementary shape a thin layer of constant thickness of a liquid specimen for immunoassay.
Claim 2
Dependent Claim 139 words
In apparatus for performing an immunoassay, comprising in combination a reaction tube closed at its bottom, and in the reaction tube a molded element having on its surface material having specific binding ability for a component in a liquid specimen to be assayed; the improvement in which the shape of the surface of the element adjacent the interior surface of the tube is the complement of the shape of the interior surface of the tube, and spacer means on the element in contact with the interior surface of the tube, said spacer means holding the element in such position in the tube that said surfaces of complementary shape are spaced from each other a small but constant distance thereby to receive between said surfaces of complementary shape a thin layer of constant thickness of a liquid specimen for immunoassay.
Claim 3
Dependent Claim 22 words
Apparatus as claimed in claim 1, in which said component to be assayed is an antibody and said material is an antigen.
Claim 4
Dependent Claim 22 words
Apparatus as claimed in claim 1, in which said component to be assayed is an antigen and said material is an antibody.
Claim 5
Dependent Claim 26 words
Apparatus as claimed in claim 1, in which said component to be assayed is a hormone or drug hapten and said material is a receptor thereof.
Claim 6
Dependent Claim 22 words
Apparatus as claimed in claim 1, in which said shape of the surface of the lower part of the element is semi-spherical.
Claim 7
Dependent Claim 21 words
Apparatus as claimed in claim 1, in which said shape of the surface of the element is a rounded spearhead shape.
Claim 8
Dependent Claim 17 words
Apparatus as claimed in claim 1, in which said spacer means comprises a rib on said element.
Claim 9
Dependent Claim 26 words
Apparatus as claimed in claim 1, and upwardly opening grooves in the upper surface of said element, said grooves opening through the edges of said element.

References Cited (Backward Citations)

DE2262479A1 Cited
US4197287A Cited
US4135884A Cited
FR2418457A1 Cited
US4225575A Cited
US4305924A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1988-01-22 1988-07-23 1989-01-22 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1992-01-22 1992-07-23 1993-01-22 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1996-01-22 1996-07-23 1997-01-22 $7700.00 Window Closed / Lapsed

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