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US4490362A
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Immunopotentiator comprising the B chain of ricin as an active ingredient
Assignee: Eisai Co Ltd
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Filing: 1982-05-26
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Granted: 1984-12-25
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Expires: 2002-05-26
Abstract
Abstract An immunopotentiator comprising the B chain of ricin as an active ingredient. The immunopotentiator serves to increase immune response to fungi, viruses and other microorganisms and is therefore effective for prevention or treatment of infectious diseases by such microorganisms.
Inventors
- 👤 Hiroshi Shionoya
- 👤 Hitoshi Takeuchi
- 👤 Gunki Funatsu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 06:02
CPC Classifications
A; A61; A61K; A61K45/00; A61K45/05; A61K38/00; A61K38/16; A61K38/168; A61K39/00; A61K39/39; A61P; A61P37/00; A61K2039/555; A61K2039/55511; A61K2039/55516
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
45 words
An aqueous immunopotentiator composition comprising the B chain of ricin in an aqueous solution, said aqueous composition being in an injectable dosage form, and wherein the B chain of ricin is present in said aqueous composition in a concentration of 10 ng to 100 mg/ml.
Claim 2
Dependent Claim
45 words
An aqueous immunopotentiator composition comprising the B chain of ricin in an aqueous solution, said aqueous composition being in an injectable dosage form, and wherein the B chain of ricin is present in said aqueous composition in a concentration of 10 ng to 100 mg/ml.
Claim 3
Dependent Claim
34 words
The aqueous composition of claim 1 wherein the composition further comprises a stabilizing amount, to maintain the immunoactivity of the B chain ricin in solution, of lactose or a mixture of lactose and galactose.
Claim 4
Independent Claim
41 words
A method for treating a patient with an immunopotentiator to increase the immunopotentiating effects against diseases both in humoral and cellular immune response systems, which comprises administering to the patient from 1 ng to 500 μg/kg of the B-chain of ricin.
Claim 5
Independent Claim
41 words
A method for treating a patient with an immunopotentiator to increase the immunopotentiating effects against diseases both in humoral and cellular immune response systems, which comprises administering to the patient from 1 ng to 500 μg/kg of the B-chain of ricin.
Claim 6
Dependent Claim
12 words
A method according to claim 3 wherein the disease is a virus.
Claim 7
Dependent Claim
12 words
A method according to claim 3 wherein the disease is a fungus.
Claim 8
Dependent Claim
25 words
An immunopotentiating composition comprising B-chain ricin as the immunopotentiator in a concentration of from 10 ng to 100 mg and a pharmaceutically acceptable liquid carrier.
Claim 9
Dependent Claim
25 words
An immunopotentiating composition comprising B-chain ricin as the immunopotentiator in a concentration of from 10 ng to 100 mg and a pharmaceutically acceptable liquid carrier.
Claim 10
Dependent Claim
16 words
The composition of claim 6 which further comprises lactose or lactase and galactose as an additive.
References Cited (Backward Citations)
EP0028815A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-25 | 1988-06-25 | 1988-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-25 | 1992-06-25 | 1992-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-25 | 1996-06-25 | 1996-12-25 | $7700.00 | Window Closed / Lapsed |