Patent US4489156A successfully refreshed from Google Patents.
US4489156A
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Chloramphenicol derivatives
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1981-04-23
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Granted: 1984-12-18
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Expires: 2001-04-23
Abstract
Abstract Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxocarbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.
Inventors
- 👤 Pyare Khanna
- 👤 Evan S. Snyder
- 👤 Prithipal Singh
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 13:26
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; G01N33/9446; Y; Y10; Y10S; Y10S435/00; Y10S435/81; Y10S435/961; Y10S435/964; Y10S530/00; Y10S530/806; Y10S530/807
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
93 words
A compound of the formula: ##STR4## wherein: R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms consisting of carbon, nitrogen, and chalcogen of atomic no. 8 to 16; Z is a poly(amino acid) consisting of polypeptides and proteins having 1 or more subunits and a molecular weight of at least about 5000, which is antigenic or an enzyme; m is 0 or 1, and n is a number between 1 and the molecular weight of Z divided by 1000.
Claim 2
Dependent Claim
93 words
A compound of the formula: ##STR4## wherein: R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms consisting of carbon, nitrogen, and chalcogen of atomic no. 8 to 16; Z is a poly(amino acid) consisting of polypeptides and proteins having 1 or more subunits and a molecular weight of at least about 5000, which is antigenic or an enzyme; m is 0 or 1, and n is a number between 1 and the molecular weight of Z divided by 1000.
Claim 3
Dependent Claim
18 words
A compound according to claim 1, wherein R is a 1-oxopolymethylene of from 3 to 5 carbon atoms.
Claim 4
Dependent Claim
13 words
A compound according to claim 2, wherein R is of 4 carbon atoms.
Claim 5
Dependent Claim
70 words
A compound of the formula: ##STR5## wherein: R is a saturated aliphatic linking group of from 2 to 6 carbon atoms having from 0 to 1 oxo-carbonyl group at its terminus bonded to nitrogen; Y 1 is a poly(amino acid) of at least about 2000 molecular weight, functioning as an antigen or enzyme; and n 1 is a number one and the molecular weight of Y 1 divided by 2000.
Claim 6
Dependent Claim
70 words
A compound of the formula: ##STR5## wherein: R is a saturated aliphatic linking group of from 2 to 6 carbon atoms having from 0 to 1 oxo-carbonyl group at its terminus bonded to nitrogen; Y 1 is a poly(amino acid) of at least about 2000 molecular weight, functioning as an antigen or enzyme; and n 1 is a number one and the molecular weight of Y 1 divided by 2000.
Claim 7
Dependent Claim
23 words
A compound according to claim 4, wherein R has an oxo-carbonyl at its terminus bonded to nitrogen and is of 4 carbon atoms.
Claim 8
Dependent Claim
16 words
A compound according to any of claims 4 or 5, wherein Y 1 is an antigen.
Claim 9
Dependent Claim
16 words
A compound according to any of claims 4 or 5, wherein Y 1 is an enzyme.
Claim 10
Dependent Claim
12 words
A compound according to claim 7, wherein said enzyme is glucose-6-phosphate dehydrogenase.
References Cited (Backward Citations)
US3817837A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-18 | 1988-06-18 | 1988-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-18 | 1992-06-18 | 1992-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-18 | 1996-06-18 | 1996-12-18 | $7700.00 | Window Closed / Lapsed |