Patent US4486435A successfully refreshed from Google Patents.
US4486435A
Expired / Lapsed
US
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Spray-dried vitamin powders using hydrophobic silica
Assignee: BASF Corp
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Filing: 1983-05-16
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Granted: 1984-12-04
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Expires: 2003-05-16
Abstract
Abstract Encapsulated vitamin powders coated with a hydrophobic silica have improved free-flowing properties making these powders more suitable for direct tableting preparation.
Inventors
- 👤 Douglass N. Schmidt
- 👤 Jeffrey L. Finnan
- 👤 Rudolph E. Lisa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 08:39
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
111 words
In a process for preparing coated, non-agglomerated, spray-dried vitamin powders suitable for the preparation of tablets by direct compression comprising: A. spraying into a spray-dryer chamber droplets of a composition containing a vitamin present as a dispersion, solution, or as an emulsion in an aqueous medium containing an encapsulating agent and wherein a water-insoluble carrier is optionally present in said aqueous medium, to produce a spray-dried powder which is dried in the presence of a dry particulate absorbent material, the improvement comprising: B. metering into said chamber, in a concentration of about 0.2 to about 2 percent by weight, based upon the weight of said spray-dried vitamin powder, a hydrophobic silica.
Claim 2
Dependent Claim
111 words
In a process for preparing coated, non-agglomerated, spray-dried vitamin powders suitable for the preparation of tablets by direct compression comprising: A. spraying into a spray-dryer chamber droplets of a composition containing a vitamin present as a dispersion, solution, or as an emulsion in an aqueous medium containing an encapsulating agent and wherein a water-insoluble carrier is optionally present in said aqueous medium, to produce a spray-dried powder which is dried in the presence of a dry particulate absorbent material, the improvement comprising: B. metering into said chamber, in a concentration of about 0.2 to about 2 percent by weight, based upon the weight of said spray-dried vitamin powder, a hydrophobic silica.
Claim 3
Dependent Claim
31 words
The process of claim 1 wherein said vitamin is present as a dispersion in said aqueous medium containing said encapsulating agent comprising a water-soluble starch, dextrin, corn syrup, or mixtures thereof.
Claim 4
Dependent Claim
32 words
The process of claim 2 wherein said water-insoluble carrier is present and selected from the group consisting of calcium sulfate, dicalcium phosphate, oyster shell flour, corn starch, rice starch, and mixtures thereof.
Claim 5
Dependent Claim
15 words
The process of claim 3 wherein said vitamin is riboflavin and said dextrin is maltodextrin.
Claim 6
Dependent Claim
53 words
The process of claim 4 wherein said non-agglomerated powder has the following composition on a dry basis: riboflavin--about 45 to about 60 percent by weight, encapsulating agent--about 20 to about 52 percent by weight, calcium sulfate dihydrate--about 2 to about 18 percent by weight, hydrophobic silica--about 0.2 to about 2 percent by weight.
Claim 7
Dependent Claim
61 words
A spray-dried, free-flowing, non-agglomerated, non-caking, non-hygroscopic vitamin powder composition comprising in percent by weight based upon the total weight of said powder, about 45 to about 60 percent vitamin, about 10 to about 60 percent of an encapsulating agent, optionally about 2 to about 18 percent of a water-insoluble, carrier, and about 0.2 to about 2 percent of a hydrophobic silica.
Claim 8
Dependent Claim
61 words
A spray-dried, free-flowing, non-agglomerated, non-caking, non-hygroscopic vitamin powder composition comprising in percent by weight based upon the total weight of said powder, about 45 to about 60 percent vitamin, about 10 to about 60 percent of an encapsulating agent, optionally about 2 to about 18 percent of a water-insoluble, carrier, and about 0.2 to about 2 percent of a hydrophobic silica.
Claim 9
Dependent Claim
25 words
The composition of claim 6 wherein said encapsulating agent is selected from the group consisting of a water-soluble starch, dextrin, corn syrup and mixtures thereof.
Claim 10
Dependent Claim
10 words
The composition of claim 7 wherein said dextrin is maltodextrin.
Claim 11
Dependent Claim
32 words
The composition of claim 7 wherein said water-insoluble carrier is present and selected from the group consisting of calcium sulfate, dicalcium phosphate, oyster shell flour, corn starch, rice starch, and mixtures thereof.
Claim 12
Dependent Claim
26 words
The composition of claim 9 wherein said vitamin is riboflavin and said powder is coated with about 0.5 to about 1.5 percent of said hydrophobic silica.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-04 | 1988-06-04 | 1988-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-04 | 1992-06-04 | 1992-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-04 | 1996-06-04 | 1996-12-04 | $7700.00 | Window Closed / Lapsed |